White Sox vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 7:11 p.m.

The Chicago White Sox versus the Baltimore Orioles is on the MLB schedule for Tuesday.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

White Sox vs Orioles Game Info

• Chicago White Sox (57-94) vs. Baltimore Orioles (70-80)
• Date: Tuesday, September 16, 2025
• Time: 7:40 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MASN2

White Sox vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHW: (-110) | BAL: (-106)
• Spread: CHW: +1.5 (-188) | BAL: -1.5 (+155)
• Total: 8 -- Over: (-105) | Under: (-115)

White Sox vs Orioles Probable Starting Pitchers

Probable Pitchers: Shane Smith (White Sox) - 6-7, 3.78 ERA vs Dean Kremer (Orioles) - 9-10, 4.43 ERA

The White Sox will call on Shane Smith (6-7) versus the Orioles and Dean Kremer (9-10). Smith and his team have a record of 14-12-0 against the spread when he starts. Smith's team lost his only start as a favorite this season. The Orioles have a 14-13-0 ATS record in Kremer's 27 starts that had a set spread. The Orioles have a 6-9 record in Kremer's 15 starts this season when they were the underdog on the moneyline.

White Sox vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Orioles win (50.8%)

White Sox vs Orioles Moneyline

• Looking at the moneyline for White Sox-Orioles, Chicago is the favorite at -110, and Baltimore is -106 playing on the road.

White Sox vs Orioles Spread

• The Orioles are 1.5-run favorites against the spread for this matchup with the White Sox. The Orioles are +155 to cover, while the White Sox are -188 to cover as a 1.5-run underdog on the runline.

White Sox vs Orioles Over/Under

• White Sox versus Orioles, on Sept. 16, has an over/under of 8, with the over being -105 and the under -115.

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White Sox vs Orioles Betting Trends

• The White Sox have split the two games they have played as odds-on favorites this season.
• Chicago has been listed as a favorite of -110 or more on two occasions this season and split those games.
• Contests with the White Sox have gone over the total set by oddsmakers in 67 of 146 chances this season.
• The White Sox have posted a record of 83-63-0 against the spread this season.
• The Orioles have been the underdog on the moneyline 84 total times this season. They've finished 38-46 in those games.
• Baltimore has a 37-46 record (winning 44.6% of its games) when playing as a moneyline underdog of -106 or longer.
• The Orioles have played in 147 games with an over/under set, and have combined with their opponents to go over the total 62 times (62-81-4).
• The Orioles have a 71-76-0 record ATS this season (covering 48.3% of the time).

White Sox Player Leaders

• Miguel Vargas has 107 hits this season and a team-best OBP of .312. He has a .231 batting average and a slugging percentage of .397.
• Among all qualifying batters in baseball, he ranks 129th in batting average, 109th in on-base percentage, and 105th in slugging.
• Andrew Benintendi is hitting .240 with 16 doubles, two triples, 19 home runs and 38 walks. He's slugging .424 with an on-base percentage of .304.
• Lenyn Sosa leads Chicago in slugging percentage (.426) and total hits (126) this season.
• Chase Meidroth has five home runs, 23 RBI and a batting average of .270 this season.
• Meidroth has hit safely in 11 straight games. In his last 10 games he is hitting .406 with a home run, five walks and two RBIs.

Orioles Player Leaders

• Gunnar Henderson has accumulated 143 hits with a .346 on-base percentage and a .439 slugging percentage, all club-bests for the Orioles. He's batting .269.
• Including all the qualifying hitters in MLB, his batting average puts him 40th, his on-base percentage ranks 42nd, and he is 66th in slugging.
• Jackson Holliday is batting .255 with 21 doubles, three triples, 17 home runs and 52 walks. He's slugging .396 with an on-base percentage of .325.
• Including all qualifying hitters, he is 81st in batting average, 83rd in on-base percentage and 106th in slugging percentage.
• Colton Cowser is batting .202 with 12 doubles, 15 home runs and 22 walks.
• Ryan Mountcastle has 18 doubles, five home runs and 14 walks while batting .256.

White Sox vs Orioles Head to Head

• 9/15/2025: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 2-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/4/2024: 8-1 CHW (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/3/2024: 9-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 9/2/2024: 13-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -460, Underdog Moneyline: +360)
• 5/25/2024: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/24/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 5/23/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -240, Underdog Moneyline: +194)

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