Yankees vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:11 p.m.

MLB action on Thursday includes the New York Yankees taking on the Boston Red Sox.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Yankees vs Red Sox Game Info

• New York Yankees (69-57) vs. Boston Red Sox (68-59)
• Date: Thursday, August 21, 2025
• Time: 7:15 p.m. ET
• Venue: Yankee Stadium -- The Bronx, New York
• Coverage: FOX

Yankees vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-144) | BOS: (+122)
• Spread: NYY: -1.5 (+140) | BOS: +1.5 (-170)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Yankees vs Red Sox Probable Starting Pitchers

Probable Pitchers: Luis Gil (Yankees) - 1-1, 5.14 ERA vs Lucas Giolito (Red Sox) - 8-2, 3.63 ERA

The Yankees will give the nod to Luis Gil (1-1, 5.14 ERA), who is eyeing win No. 2 on the season, and the Red Sox will counter with Lucas Giolito (8-2, 3.63 ERA). Gil's team is 1-2-0 against the spread this season in his starts. Gil's team has won 66.7% of his starts when they are favored on the moneyline (2-1). The Red Sox are 13-6-0 ATS in Giolito's 19 starts with a set spread. The Red Sox have been the underdog on the moneyline in 10 of Giolito's starts this season, and they went 6-4 in those games.

Yankees vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (61.1%)

Yankees vs Red Sox Moneyline

• Boston is the underdog, +122 on the moneyline, while New York is a -144 favorite at home.

Yankees vs Red Sox Spread

• The Yankees are hosting the Red Sox and are favored by 1.5 runs on the spread. The Yankees are +140 to cover the runline, with the Red Sox being -170.

Yankees vs Red Sox Over/Under

• Yankees versus Red Sox on Aug. 21 has an over/under of 8.5 runs, with the odds on the over -120 and the under set at -102.

Bet on New York Yankees vs. Boston Red Sox on FanDuel today!

Yankees vs Red Sox Betting Trends

• The Yankees have been favorites in 104 games this season and have come away with the win 60 times (57.7%) in those contests.
• This year New York has won 45 of 69 games when listed as at least -144 on the moneyline.
• The Yankees' games have gone over the total in 58 of their 124 opportunities.
• In 124 games with a line this season, the Yankees have a mark of 55-69-0 against the spread.
• The Red Sox have been the underdog on the moneyline 44 total times this season. They've gone 20-24 in those games.
• In games it has played as a moneyline underdog with odds of +122 or longer, Boston has a 7-13 record (winning only 35% of its games).
• The Red Sox have had an over/under set by bookmakers 126 times, and have combined with opponents to go over the total in 61 of those games (61-60-5).
• The Red Sox have covered 54.8% of their games this season, going 69-57-0 against the spread.

Yankees Player Leaders

• Aaron Judge leads New York in OBP (.445), slugging percentage (.684) and total hits (139) this season. He has a .330 batting average.
• Among the qualifying hitters in MLB, his batting average ranks first, his on-base percentage ranks first, and he is first in slugging.
• Cody Bellinger is hitting .272 with 20 doubles, five triples, 24 home runs and 37 walks. He's slugging .498 with an on-base percentage of .325.
• Among qualifiers, he is 43rd in batting average, 86th in on-base percentage and 21st in slugging percentage.
• Bellinger has picked up a hit in three straight games. During his last five outings he is batting .333 with three home runs, a walk and seven RBIs.
• Trent Grisham has 93 hits this season and has a slash line of .249/.353/.464.
• Anthony Volpe has been key for New York with 95 hits, an OBP of .280 plus a slugging percentage of .409.

Red Sox Player Leaders

• Jarren Duran has put up a team-best OBP (.336) and slugging percentage (.451). He's batting .261.
• He ranks 69th in batting average, 63rd in on-base percentage and 62nd in slugging percentage among all qualifying batters in the big leagues.
• Trevor Story is hitting .259 with 21 doubles, 19 home runs and 25 walks. He's slugging .423 with an on-base percentage of .302.
• Including all qualifying hitters, he ranks 76th in batting average, 126th in on-base percentage and 86th in slugging percentage.
• Ceddanne Rafaela has 25 doubles, three triples, 14 home runs and 21 walks while hitting .252.
• Alex Bregman has 23 doubles, 16 home runs and 36 walks while batting .298.

Yankees vs Red Sox Head to Head

• 6/15/2025: 2-0 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/14/2025: 4-3 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/13/2025: 2-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 6/8/2025: 11-7 BOS (Favorite: Yankees, Spread: -1.5, Total: 8, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 6/7/2025: 10-7 BOS (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/6/2025: 9-6 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 9/15/2024: 5-2 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/14/2024: 7-1 BOS (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/13/2024: 5-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 9/12/2024: 2-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)

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