Cardinals vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:12 p.m.

MLB action on Thursday includes the St. Louis Cardinals facing the Tampa Bay Rays.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Cardinals vs Rays Game Info

• St. Louis Cardinals (63-65) vs. Tampa Bay Rays (61-66)
• Date: Thursday, August 21, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and FDSMW

Cardinals vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-118) | TB: (-100)
• Spread: STL: -1.5 (+140) | TB: +1.5 (-170)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Cardinals vs Rays Probable Starting Pitchers

Probable Pitchers: Sonny Gray (Cardinals) - 11-6, 4.30 ERA vs Joe Boyle (Rays) - 1-2, 4.68 ERA

The Cardinals will give the nod to Sonny Gray (11-6) against the Rays and Joe Boyle (1-2). Gray's team is 12-11-0 against the spread in his starts this season. Gray's team has been victorious in 73.3% of the games he's started as the moneyline favorite with a record of 11-4. The Rays are 1-4-0 against the spread when Boyle starts. The Rays have been the underdog on the moneyline in five of Boyle's starts this season, and they went 2-3 in those games.

Cardinals vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (50.1%)

Cardinals vs Rays Moneyline

• Tampa Bay is the underdog, -100 on the moneyline, while St. Louis is a -118 favorite despite being on the road.

Cardinals vs Rays Spread

• The Cardinals are 1.5-run road favorites on the runline against the Rays. The Cardinals are +140 to cover, and the Rays are -170.

Cardinals vs Rays Over/Under

• The Cardinals-Rays contest on Aug. 21 has been given an over/under of 8.5 runs. The over is set at -105 and the under at -115.

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Cardinals vs Rays Betting Trends

• The Cardinals have won in 27, or 50%, of the 54 contests they have been named as odds-on favorites in this year.
• St. Louis has a record of 23-21 when favored by -118 or more this year.
• The Cardinals' games have gone over the total in 63 of their 123 opportunities.
• In 123 games with a line this season, the Cardinals have a mark of 63-60-0 against the spread.
• The Rays have gone 24-37 in games they were listed as the moneyline underdog (winning 39.3% of those games).
• Tampa Bay has a record of 19-27 when it has played as a moneyline underdog with odds of -100 or longer (41.3%).
• The Rays have combined with opponents to go over the total 51 times this season for a 51-66-6 record against the over/under.
• The Rays have a 52-71-0 record ATS this season (covering 42.3% of the time).

Cardinals Player Leaders

• Alec Burleson leads St. Louis in total hits (115) this season while batting .284 with 36 extra-base hits. He has an on-base percentage of .336 and a slugging percentage of .449.
• Among qualifying hitters in the majors, he ranks 24th in batting average, 63rd in on-base percentage, and 65th in slugging.
• Willson Contreras is batting .259 with 29 doubles, 17 home runs and 39 walks. He's slugging .448 with an on-base percentage of .344.
• His batting average is 76th among qualified players, his on-base percentage 49th, and his slugging percentage 67th.
• Contreras brings a three-game streak with at least one hit into this one. During his last five outings he is hitting .294 with a home run, a walk and two RBIs.
• Masyn Winn is batting .260 with a .381 slugging percentage and 46 RBI this year.
• Lars Nootbaar is batting .240 with a .330 OBP and 43 RBI for St. Louis this season.
• Nootbaar takes a four-game hitting streak into this game. In his last five games he is batting .409 with a double and two RBIs.

Rays Player Leaders

• Junior Caminero is leading the Rays with 121 hits. He's batting .255 and slugging .521 with an on-base percentage of .297.
• Including all qualifying hitters in MLB, his batting average places him 89th, his on-base percentage is 138th, and he is 12th in slugging.
• Yandy Diaz is slugging .455 to lead his team. He has a batting average of .279 with an on-base percentage of .339.
• He is currently 28th in batting average, 56th in on-base percentage and 58th in slugging percentage among all qualifying hitters.
• Brandon Lowe has 13 doubles, 24 home runs and 29 walks while hitting .269.
• Chandler Simpson is batting .299 with 10 doubles, two triples and 16 walks.

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