Orioles vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 21

Odds updated as of 7:11 p.m.

The MLB's Thursday schedule includes the Baltimore Orioles facing the Houston Astros.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Orioles vs Astros Game Info

• Baltimore Orioles (59-67) vs. Houston Astros (69-58)
• Date: Thursday, August 21, 2025
• Time: 7:15 p.m. ET
• Venue: Oriole Park at Camden Yards -- Baltimore, Maryland
• Coverage: FOX

Orioles vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-118) | HOU: (-100)
• Spread: BAL: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 8.5 -- Over: (-120) | Under: (-102)

Orioles vs Astros Probable Starting Pitchers

Probable Pitchers: Brandon Young (Orioles) - 1-6, 5.68 ERA vs Jason Alexander (Astros) - 3-1, 4.74 ERA

The probable starters are Brandon Young (1-6) for the Orioles and Jason Alexander (3-1) for the Astros. Young and his team are 5-5-0 ATS this season when he starts. Young's team is 1-1 this season when he starts and they're favored on the moneyline. The Astros have a 4-2-0 record against the spread in Alexander's starts. The Astros were the moneyline underdog for two Alexander starts this season -- they won both.

Orioles vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.1%)

Orioles vs Astros Moneyline

• Baltimore is a -118 favorite on the moneyline, while Houston is a -100 underdog on the road.

Orioles vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Orioles. The Astros are +168 to cover, while the Orioles are -205 to cover as a 1.5-run underdog on the runline.

Orioles vs Astros Over/Under

• The over/under for the Orioles versus Astros game on Aug. 21 has been set at 8.5, with -120 odds on the over and -102 odds on the under.

Bet on Baltimore Orioles vs. Houston Astros on FanDuel today!

Orioles vs Astros Betting Trends

• The Orioles have been chosen as favorites in 53 games this year and have walked away with the win 24 times (45.3%) in those games.
• This season Baltimore has come away with a win 21 times in 44 chances when named as a favorite of at least -118 on the moneyline.
• The Orioles and their opponents have gone over in 53 of their 123 games with a total set by sportsbooks this season.
• The Orioles have an against the spread record of 58-65-0 in 123 games with a line this season.
• The Astros have won 24 of the 41 games they were listed as the moneyline underdog this season (58.5%).
• When playing as a moneyline underdog with odds of -100 or longer, Houston has a 17-12 record (winning 58.6% of its games).
• The Astros have had an over/under set by oddsmakers 126 times, and have combined with opponents to go over the total in 57 of those games (57-65-4).
• The Astros have put together a 62-64-0 record against the spread this season.

Orioles Player Leaders

• Gunnar Henderson leads Baltimore in OBP (.353), slugging percentage (.470) and total hits (125) this season. He has a .281 batting average.
• He ranks 26th in batting average, 37th in on-base percentage, and 44th in slugging among all qualified batters in baseball.
• Henderson hopes to build on a two-game hitting streak in this matchup. During his last five outings he is hitting .222 with a triple, a home run, four walks and six RBIs.
• Jackson Holliday is hitting .248 with 17 doubles, two triples, 15 home runs and 34 walks. He's slugging .389 with an on-base percentage of .306.
• His batting average is 103rd among qualified players, his on-base percentage 120th, and his slugging percentage 121st.
• Jordan Westburg has 78 hits this season and has a slash line of .276/.326/.473.
• Adley Rutschman has been key for Baltimore with 70 hits, an OBP of .310 plus a slugging percentage of .373.

Astros Player Leaders

• Jose Altuve has racked up a team-best .459 slugging percentage. He's batting .276 with an on-base percentage of .340.
• Including all qualified hitters, he ranks 37th in batting average, while his on-base percentage ranks 54th and he is 55th in slugging.
• Jeremy Pena's 117 hits and .368 OBP are both team-highs. He has a batting average of .310 while slugging .479.
• Including all qualified players, he ranks third in batting average, 18th in on-base percentage and 33rd in slugging percentage.
• Yainer Diaz has 16 doubles, a triple, 17 home runs and 17 walks while batting .255.
• Carlos Correa has 22 doubles, nine home runs and 32 walks while batting .278.

Orioles vs Astros Head to Head

• 8/17/2025: 12-0 BAL (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 8/16/2025: 5-4 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 8/15/2025: 7-0 BAL (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/25/2024: 6-3 HOU (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/24/2024: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/23/2024: 7-5 BAL (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/22/2024: 6-0 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 6/23/2024: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 6/22/2024: 5-1 HOU (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/21/2024: 14-11 HOU (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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