Virginia Tech vs Vanderbilt Prediction, Odds, Picks, Best Bets for Week 2 2025

The Virginia Tech Hokies will take on the Vanderbilt Commodores in college football action on Saturday.

We've got you covered, in terms of the vital information about NCAA football betting lines, before you make your wager on FanDuel Sportsbook.

Virginia Tech vs Vanderbilt Odds & Spread

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• All college football odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: Virginia Tech: (-125) | Vanderbilt: (+104)
• Spread: Virginia Tech: -2.5 (-102) | Vanderbilt: +2.5 (-120)
• Total: 44.5 -- Over: (-110) | Under: (-110)

Virginia Tech vs Vanderbilt Betting Trends

• Virginia Tech has no wins against the spread this season.
• Vanderbilt is unbeaten against the spread this season.
• No Vanderbilt game has gone over the point total this season.

Virginia Tech vs Vanderbilt Prediction & Pick

All college football win probability predictions and picks are according to numberFire.
Prediction: Hokies win (59%)

Virginia Tech vs Vanderbilt Point Spread

Virginia Tech is favored by 2.5 points (-102 to cover) in this matchup. Vanderbilt, the underdog, is -120.

Virginia Tech vs Vanderbilt Over/Under

Virginia Tech versus Vanderbilt on Sept. 6 has an over/under of 44.5 points, with the over -110 and the under -110.

Virginia Tech vs Vanderbilt Moneyline

Looking at the moneyline for Vanderbilt-Virginia Tech, Vanderbilt is the underdog at +104, and Virginia Tech is -125.

Virginia Tech vs. Vanderbilt Points Insights

• The Hokies' average implied point total last season was 6.1 more points than their implied total in Saturday's game (30.1 implied points on average compared to 24 implied points in this game).
• The Commodores' average implied point total last season (32.1 points) is 11.1 points higher than their implied total in this matchup (21 points).

Virginia Tech vs. Vanderbilt Game Info

• Game day: Saturday, September 6, 2025
• Game time: 7:30 p.m. ET
• TV channel: ACC Network
• Location: Blacksburg, Virginia
• Stadium: Lane Stadium

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Check out even more in-depth Virginia Tech vs. Vanderbilt analysis on FanDuel Research.