Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 4

Odds updated as of 8:12 a.m.

The Tampa Bay Rays are among the MLB teams in action on Thursday, versus the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information about this matchup.

Rays vs Guardians Game Info

• Tampa Bay Rays (70-69) vs. Cleveland Guardians (69-69)
• Date: Thursday, September 4, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-148) | CLE: (+126)
• Spread: TB: -1.5 (+130) | CLE: +1.5 (-156)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Ryan Pepiot (Rays) - 10-10, 3.70 ERA vs Logan Allen (Guardians) - 7-10, 4.42 ERA

This contest's pitching matchup is set, as the Rays will send Ryan Pepiot (10-10) to the mound, while Logan Allen (7-10) will get the nod for the Guardians. Pepiot's team is 9-18-0 against the spread in his starts this season. Pepiot's team is 8-5 this season when he starts and they are the moneyline favorite. The Guardians are 12-12-0 against the spread when Allen starts. The Guardians are 6-9 in Allen's 15 starts this season that they were the moneyline underdog.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (63.7%)

Rays vs Guardians Moneyline

• Tampa Bay is the favorite, -148 on the moneyline, while Cleveland is a +126 underdog on the road.

Rays vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Rays. The Guardians are -156 to cover the spread, and the Rays are +130.

Rays vs Guardians Over/Under

• A combined run total of 8.5 has been set for Rays-Guardians on Sept. 4, with the over at -122 and the under at -100.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have been chosen as favorites in 62 games this year and have walked away with the win 37 times (59.7%) in those games.
• Tampa Bay has a record of 7-12 in contests when oddsmakers favor them by -148 or more on the moneyline.
• The Rays and their opponents have gone over the total this season in 58 of their 134 opportunities.
• The Rays have posted a record of 60-74-0 against the spread this season.
• The Guardians have compiled a 33-45 record in games they were listed as the moneyline underdog (winning 42.3% of those games).
• Cleveland has a 15-15 record (winning 50% of its games) when playing as a moneyline underdog of +126 or longer.
• The Guardians have combined with opponents to go over the total 61 times this season for a 61-68-6 record against the over/under.
• The Guardians have a 70-65-0 record ATS this season (covering 51.9% of the time).

Rays Player Leaders

• Junior Caminero has 138 hits, which is best among Tampa Bay hitters this season, while batting .263 with 65 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .540.
• Among all qualified hitters in the majors, his batting average ranks 66th, his on-base percentage ranks 126th, and he is ninth in slugging.
• Caminero hopes to build on a three-game hitting streak in this matchup. During his last five outings he is hitting .400 with three doubles, a home run, a walk and eight RBIs.
• Yandy Diaz is slashing .294/.353/.479 this season and leads the Rays with an OPS of .832.
• Among qualified hitters, his batting average ranks him 12th, his on-base percentage 36th, and his slugging percentage 37th.
• Diaz brings a three-game streak with at least one hit into this contest. During his last five outings he is hitting .500 with two doubles, three walks and two RBIs.
• Brandon Lowe is batting .265 with a .493 slugging percentage and 74 RBI this year.
• Lowe takes a seven-game hitting streak into this game. In his last 10 outings he is hitting .229 with two doubles, three home runs, five walks and 11 RBIs.
• Chandler Simpson has been key for Tampa Bay with 99 hits, an OBP of .328 plus a slugging percentage of .344.
• Simpson has hit safely in three games in a row. In his last five games he is batting .273 with .

Guardians Player Leaders

• Jose Ramirez has racked up 140 hits with a .353 on-base percentage, leading the Guardians in both statistics. He's batting .278 and slugging .491.
• He ranks 29th in batting average, 36th in on-base percentage and 28th in slugging percentage among all qualified hitters in the majors.
• Steven Kwan's .382 slugging percentage leads his team. He has a batting average of .274 with an on-base percentage of .330.
• Including all qualified players, he ranks 37th in batting average, 78th in on-base percentage and 128th in slugging percentage.
• Kyle Manzardo is hitting .231 with 14 doubles, two triples, 24 home runs and 42 walks.
• Angel Martinez is batting .226 with 21 doubles, a triple, 10 home runs and 17 walks.

Rays vs Guardians Head to Head

• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/13/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 7/12/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)

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