Twins vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 7:14 a.m.

The MLB's Wednesday schedule includes the Minnesota Twins taking on the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Twins vs White Sox Game Info

• Minnesota Twins (62-76) vs. Chicago White Sox (51-88)
• Date: Wednesday, September 3, 2025
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: MNNT and CHSN

Twins vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-172) | CHW: (+144)
• Spread: MIN: -1.5 (+116) | CHW: +1.5 (-138)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Twins vs White Sox Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 4-4, 5.06 ERA vs Yoendrys Gomez (White Sox) - 3-2, 5.20 ERA

The Twins will give the ball to Zebby Matthews (4-4, 5.06 ERA), who is eyeing win No. 5 on the season, and the White Sox will turn to Yoendrys Gomez (3-2, 5.20 ERA). Matthews' team is 5-7-0 against the spread this season in his starts. Matthews' team is 4-3 this season when he starts and they are the moneyline favorite. The White Sox have a 3-1-0 record against the spread in Gomez's starts. The White Sox are 3-1 in Gomez's four starts this season that they were the moneyline underdog.

Twins vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (69%)

Twins vs White Sox Moneyline

• Minnesota is the favorite, -172 on the moneyline, while Chicago is a +144 underdog on the road.

Twins vs White Sox Spread

• The White Sox are at the Twins, and are +1.5 on the runline. The White Sox are +116 to cover the spread, and the Twins are -138.

Twins vs White Sox Over/Under

• Twins versus White Sox on Sept. 3 has an over/under of 8.5 runs, with the odds on the over -115 and the under set at -105.

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Twins vs White Sox Betting Trends

• The Twins have been favorites in 79 games this season and have come away with the win 39 times (49.4%) in those contests.
• Minnesota has a record of 11-7 in contests when sportsbooks favor them by -172 or more on the moneyline.
• The Twins and their opponents have gone over in 63 of their 133 games with a total set by sportsbooks this season.
• The Twins are 65-68-0 against the spread in their 133 games with a line set by sportsbooks this season.
• The White Sox are 47-84 in games they were listed as the moneyline underdog (winning 35.9% of those games).
• In games it has played as a moneyline underdog with odds of +144 or longer, Chicago has a 20-47 record (winning just 29.9% of its games).
• The White Sox have played in 134 games with an over/under set, and have combined with their opponents to go over the total 62 times (62-64-8).
• The White Sox have a 75-59-0 record against the spread this season.

Twins Player Leaders

• Byron Buxton has 110 hits, which leads Minnesota hitters this season, while batting .272 with 51 extra-base hits. He has an on-base percentage of .333 and a slugging percentage of .553.
• Among qualifying hitters in the majors, his batting average ranks 39th, his on-base percentage ranks 70th, and he is fifth in slugging.
• Buxton will look for his seventh straight game with a hit in this contest. During his last 10 games he is batting .282 with two doubles, a triple, four home runs, four walks and 11 RBIs.
• Trevor Larnach leads Minnesota in slugging percentage (.414) thanks to 37 extra-base hits. He's batting .254 with an on-base percentage of .327.
• Among all qualifying players, he is 88th in batting average, 84th in on-base percentage and 90th in slugging percentage.
• Larnach heads into this game looking to extend his four-game hit streak. During his last five outings he is batting .529 with a double, a walk and four RBIs.
• Brooks Lee has collected 101 base hits, an OBP of .293 and a slugging percentage of .383 this season.
• Lee enters this matchup with three games in a row with at least one hit. In his last five games he is hitting .158 with a walk and an RBI.
• Ryan Jeffers leads Minnesota in OBP (.349) this season, fueled by 98 hits.

White Sox Player Leaders

• Andrew Benintendi has 15 doubles, two triples, 17 home runs and 34 walks while batting .245. He's slugging .428 with an on-base percentage of .307.
• Lenyn Sosa leads his team with 118 hits and has a club-best .436 slugging percentage. He has a batting average of .265 with an on-base percentage of .296.
• He is currently 57th in batting average, 136th in on-base percentage and 76th in slugging percentage among all qualified hitters.
• Chase Meidroth has 14 doubles, four home runs and 38 walks while batting .253.
• Mike Tauchman is hitting .271 with 15 doubles, a triple, eight home runs and 40 walks.

Twins vs White Sox Head to Head

• 9/2/2025: 12-3 CHW (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 9/1/2025: 6-5 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 8/24/2025: 8-0 CHW (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/23/2025: 7-3 CHW (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/22/2025: 9-7 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/24/2025: 3-0 CHW (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/23/2025: 6-3 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -260, Underdog Moneyline: +215)
• 4/22/2025: 4-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 4/2/2025: 6-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 4/1/2025: 8-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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