Yankees vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 7:16 a.m.

Wednesday's slate in the MLB includes a matchup between the New York Yankees and the Houston Astros.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Yankees vs Astros Game Info

• New York Yankees (77-61) vs. Houston Astros (76-63)
• Date: Wednesday, September 3, 2025
• Time: 8:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: MLB Network, SCHN, and Amazon Prime Video

Yankees vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: NYY: (-126) | HOU: (+108)
• Spread: NYY: -1.5 (+116) | HOU: +1.5 (-140)
• Total: 9 -- Over: (-106) | Under: (-114)

Yankees vs Astros Probable Starting Pitchers

Probable Pitchers: Will Warren (Yankees) - 8-6, 4.30 ERA vs Jason Alexander (Astros) - 4-1, 4.61 ERA

The Yankees will give the ball to Will Warren (8-6, 4.30 ERA), who is eyeing win No. 9 on the season, and the Astros will turn to Jason Alexander (4-1, 4.61 ERA). Warren and his team are 12-16-0 ATS this season when he starts. Warren's team is 15-8 this season when he starts and they are the moneyline favorite. The Astros have gone 5-3-0 ATS in Alexander's eight starts that had a set spread. The Astros won each of Alexander's three starts this season that they were the underdog on the moneyline.

Yankees vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Yankees win (55.4%)

Yankees vs Astros Moneyline

• New York is the favorite, -126 on the moneyline, while Houston is a +108 underdog despite being at home.

Yankees vs Astros Spread

• The Yankees are 1.5-run road favorites on the runline against the Astros. The Yankees are +116 to cover, and the Astros are -140.

Yankees vs Astros Over/Under

• A total of 9 runs has been set for the Yankees-Astros game on Sept. 3, with the over available at -106 and the under at -114.

Bet on New York Yankees vs. Houston Astros on FanDuel today!

Yankees vs Astros Betting Trends

• The Yankees have been favorites in 115 games this season and have come away with the win 68 times (59.1%) in those contests.
• New York has a record of 63-41 when favored by -126 or more this year.
• Contests with the Yankees have gone over the total set by oddsmakers in 66 of 136 chances this season.
• The Yankees are 63-73-0 against the spread in their 136 games with a line set by sportsbooks this season.
• The Astros have a 26-19 record in games they were listed as the moneyline underdog (winning 57.8% of those games).
• When it has played as a moneyline underdog with odds of +108 or longer, Houston has a record of 16-12 (57.1%).
• The Astros have played in 138 games with a set over/under, and have combined with their opponents to go over the total 62 times (62-72-4).
• The Astros have gone 68-70-0 ATS this season.

Yankees Player Leaders

• Aaron Judge leads New York with 151 hits and an OBP of .442, plus a team-best slugging percentage of .671. He's batting .325.
• Among all qualified hitters in baseball, he ranks first in batting average, first in on-base percentage, and first in slugging.
• Judge has recorded a base hit in three straight games. In his last five games he is hitting .368 with a double, two home runs, six walks and two RBIs.
• Cody Bellinger is hitting .279 with 23 doubles, five triples, 26 home runs and 42 walks, while slugging .501 with an on-base percentage of .332.
• His batting average is 27th among qualified players, his on-base percentage 73rd, and his slugging percentage 20th.
• Bellinger has picked up at least one hit in three straight games. In his last five games he is hitting .273 with two doubles, a home run, two walks and four RBIs.
• Trent Grisham has 103 hits this season and has a slash line of .248/.357/.484.
• Jazz Chisholm has 28 home runs, 70 RBI and a batting average of .243 this season.

Astros Player Leaders

• Jose Altuve has put up a slugging percentage of .456, a team-best for the Astros. He's batting .272 with an on-base percentage of .334.
• Including all the qualifying players in the majors, his batting average puts him 39th, his on-base percentage ranks 68th, and he is 54th in slugging.
• Jeremy Pena's 130 hits and .365 on-base percentage both pace his team. He has a batting average of .304 while slugging .473.
• Including all qualified players, he is fifth in batting average, 20th in on-base percentage and 39th in slugging percentage.
• Yainer Diaz is hitting .253 with 18 doubles, a triple, 18 home runs and 19 walks.
• Christian Walker has 21 doubles, a triple, 21 home runs and 38 walks while hitting .235.

Yankees vs Astros Head to Head

• 9/2/2025: 7-1 NYY (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/10/2025: 7-1 HOU (Favorite: Yankees, Spread: -1.5, Total: 9, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/9/2025: 5-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/8/2025: 5-3 HOU (Favorite: Yankees, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 5/9/2024: 4-3 HOU (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2024: 9-4 NYY (Favorite: Yankees, Spread: -1.5, Total: 9.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/7/2024: 10-3 NYY (Favorite: Yankees, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 3/31/2024: 4-3 NYY (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 3/30/2024: 5-3 NYY (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 3/29/2024: 7-1 NYY (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!