Cardinals vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 7:16 a.m.

The Wednesday slate in MLB includes a matchup between the St. Louis Cardinals and the Athletics.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cardinals vs Athletics Game Info

• St. Louis Cardinals (69-71) vs. Athletics (64-76)
• Date: Wednesday, September 3, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and NBCS-CA

Cardinals vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | OAK: (-102)
• Spread: STL: +1.5 (-194) | OAK: -1.5 (+160)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Cardinals vs Athletics Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 6-11, 4.32 ERA vs Jeffrey Springs (Athletics) - 10-9, 4.17 ERA

This contest's pitching matchup is set, as the Cardinals will send Matthew Liberatore (6-11) to the mound, while Jeffrey Springs (10-9) will answer the bell for the Athletics. When Liberatore starts, his team is 12-11-0 against the spread this season. Liberatore's team has been victorious in 30.8% of the games he's started as the moneyline favorite with a record of 4-9. The Athletics have gone 14-12-0 ATS in Springs' 26 starts with a set spread. The Athletics are 11-6 in Springs' 17 starts this season that they were the moneyline underdog.

Cardinals vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (53.5%)

Cardinals vs Athletics Moneyline

• The Cardinals vs Athletics moneyline has the Cardinals as a -116 favorite, while the Athletics are a -102 underdog on the road.

Cardinals vs Athletics Spread

• The Cardinals are hosting the Athletics and are 1.5 on the runline and -194 to cover, while Sacramento is +160 to cover the spread.

Cardinals vs Athletics Over/Under

• The Cardinals-Athletics contest on Sept. 3 has been given an over/under of 8.5 runs. The over is set at -115 and the under at -105.

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Cardinals vs Athletics Betting Trends

• The Cardinals have come away with 30 wins in the 60 contests they have been listed as the favorites in this season.
• This year, the Cardinals have won 27 of 55 games when listed as at least -116 or better on the moneyline.
• The Cardinals and their opponents have hit the over in 70 of their 134 games with a total this season.
• The Cardinals are 68-66-0 against the spread in their 134 games that had a posted line this season.
• The Athletics have won 44.2% of the games this season they were the moneyline underdog (46-58).
• The Athletics have a record of 41-57 when they have played as a moneyline underdog with odds of -102 or longer (41.8%).
• The Athletics have combined with their opponents to go over the total 70 times this season for a 70-63-6 record against the over/under.
• The Athletics have collected a 73-66-0 record against the spread this season (covering 52.5% of the time).

Cardinals Player Leaders

• Willson Contreras is hitting .249 with 30 doubles, 20 home runs and 42 walks. He has an on-base percentage of .335 while slugging .441.
• Among all qualifying hitters in baseball, his batting average ranks 98th, his on-base percentage ranks 65th, and he is 71st in slugging.
• Masyn Winn is hitting .254 with 27 doubles, nine home runs and 32 walks. He's slugging .368 with an on-base percentage of .309.
• Among qualifying hitters, his batting average ranks him 88th, his on-base percentage 115th, and his slugging percentage 139th.
• Lars Nootbaar is batting .244 with a .389 slugging percentage and 44 RBI this year.
• Nootbaar has picked up a hit in four games in a row. In his last five games he is hitting .364 with a double and a triple.
• Ivan Herrera has 13 home runs, 53 RBI and a batting average of .287 this season.
• Herrera brings an eight-game hitting streak into this matchup. In his last 10 games he is hitting .303 with a double, three home runs, five walks and six RBIs.

Athletics Player Leaders

• Brent Rooker has a team-best .492 slugging percentage. He's batting .268 with an on-base percentage of .339.
• Including all qualified hitters in the majors, his batting average places him 50th, his on-base percentage ranks 57th, and he is 29th in slugging.
• Tyler Soderstrom is batting .271 with 28 doubles, a triple, 23 home runs and 51 walks. He's slugging .468 with an on-base percentage of .343.
• Including all qualified hitters, his batting average places him 42nd, his on-base percentage is 49th, and he is 45th in slugging.
• Nick Kurtz is hitting .309 with 24 doubles, two triples, 27 home runs and 54 walks.
• Shea Langeliers paces his team with 106 hits.

Cardinals vs Athletics Head to Head

• 9/2/2025: 2-1 STL (Favorite: Athletics, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/1/2025: 11-3 OAK (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 4/17/2024: 6-3 OAK (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/16/2024: 3-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/15/2024: 3-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/16/2023: 8-0 OAK (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -178, Underdog Moneyline: +150)
• 8/15/2023: 6-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/14/2023: 7-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -240, Underdog Moneyline: +198)

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