Twins vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 2:12 p.m.

The Monday slate in MLB includes a matchup between the Minnesota Twins and the Chicago White Sox.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Twins vs White Sox Game Info

• Minnesota Twins (26-27) vs. Chicago White Sox (26-26)
• Date: Monday, May 25, 2026
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and Twins.TV

Twins vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-110) | CHW: (-106)
• Spread: MIN: -1.5 (+150) | CHW: +1.5 (-182)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Twins vs White Sox Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 1-1, 1.38 ERA vs Anthony Kay (White Sox) - 3-1, 4.27 ERA

The Twins will give the ball to Zebby Matthews (1-1, 1.38 ERA), who is eyeing win No. 2 on the season, and the White Sox will turn to Anthony Kay (3-1, 4.27 ERA). Matthews has a record of 1-1-0 ATS in two starts with a spread this season. Matthews' team is 1-1 this season when he starts and they're favored on the moneyline. The White Sox have gone 5-2-0 ATS in Kay's seven starts with a set spread. The White Sox have a 4-3 record in Kay's seven starts this season when they were the underdog on the moneyline.

Twins vs White Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (56.8%)

Twins vs White Sox Moneyline

• Looking at the moneyline for Twins-White Sox, Minnesota is the favorite at -110, and Chicago is -106 playing at home.

Twins vs White Sox Spread

• The White Sox are +1.5 on the spread (-182 to cover), and Minnesota is +150 to cover the runline.

Twins vs White Sox Over/Under

• A total of 8.5 runs has been set for the Twins-White Sox contest on May 25, with the over available at -102 and the under at -120.

Bet on Minnesota Twins vs. Chicago White Sox on FanDuel today!

Twins vs White Sox Betting Trends

• The Twins have been chosen as favorites in 17 games this year and have walked away with the win eight times (47.1%) in those games.
• This year Minnesota has won eight of 17 games when listed as at least -110 on the moneyline.
• The Twins and their opponents have gone over in 31 of their 52 games with a total set by sportsbooks this season.
• The Twins have posted a record of 29-23-0 against the spread this season.
• The White Sox have won 47.7% of the games this season they were the underdog on the moneyline (21-23).
• When playing as a moneyline underdog with odds of -106 or longer, Chicago has a 21-23 record (winning 47.7% of its games).
• In the 50 games oddsmakers have set an over/under for the White Sox, they have combined with opponents to go over the total 29 times (29-21-0).
• The White Sox have collected a 29-21-0 record against the spread this season.

Twins Player Leaders

• Byron Buxton leads Minnesota with 49 hits and a team-best slugging percentage of .578. He's batting .262 with an on-base percentage of .319.
• Among qualifying hitters, he ranks 64th in batting average, his on-base percentage ranks 99th, and he is sixth in slugging.
• Buxton has recorded at least one hit in two straight games. During his last five outings he is hitting .318 with two doubles, three home runs, a walk and five RBIs.
• Brooks Lee has eight doubles, a triple, five home runs and 13 walks. He's batting .254 and slugging .395 with an on-base percentage of .309.
• He ranks 77th in batting average, 120th in on-base percentage and 93rd in slugging in the major leagues.
• Lee enters this matchup looking to extend his two-game hit streak. In his last five games he is batting .316 with two doubles, a triple, two walks and two RBIs.
• Austin Martin leads Minnesota with an OBP of .406 this season while batting .297 with 23 walks and 18 runs scored.
• Martin enters this game with three games in a row with at least one hit. In his last five games he is batting .217 with two doubles, a home run and four RBIs.
• Luke Keaschall is batting .233 with a .318 OBP and 18 RBI for Minnesota this season.

White Sox Player Leaders

• Miguel Vargas has racked up a team-best .376 on-base percentage. He's batting .244 and slugging .500.
• Including all qualifying hitters in the big leagues, his batting average places him 98th, his on-base percentage ranks 25th, and he is 23rd in slugging.
• Vargas brings a three-game hitting streak into this game. In his last five games he is batting .286 with a double, a home run, four walks and two RBIs.
• Munetaka Murakami paces his team with 43 hits and a .376 on-base percentage. He has a batting average of .235 while slugging .530.
• Including all qualifying hitters, he is 110th in batting average, 25th in on-base percentage and 15th in slugging percentage.
• Colson Montgomery is hitting .219 with eight doubles, 13 home runs and 20 walks.
• Chase Meidroth is slugging .375 to lead his team.

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