Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 1:12 p.m.

The Chicago Cubs will take on the Pittsburgh Pirates in MLB action on Monday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cubs vs Pirates Game Info

• Chicago Cubs (29-24) vs. Pittsburgh Pirates (27-26)
• Date: Monday, May 25, 2026
• Time: 1:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-124) | PIT: (+106)
• Spread: CHC: -1.5 (+134) | PIT: +1.5 (-162)
• Total: 8 -- Over: (-115) | Under: (-105)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 1-2, 2.09 ERA vs Carmen Mlodzinski (Pirates) - 4-3, 3.96 ERA

This contest's pitching matchup is set, as the Cubs will send Ben Brown (1-2) to the mound, while Carmen Mlodzinski (4-3) will answer the bell for the Pirates. Brown's team is 2-1-0 against the spread this season in his starts. Brown's team won his only start as a favorite this season. The Pirates have gone 5-3-0 against the spread when Mlodzinski starts. The Pirates have a 3-2 record in Mlodzinski's five starts this season when they were the underdog on the moneyline.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (51.7%)

Cubs vs Pirates Moneyline

• The moneyline numbers for Cubs vs. Pirates reveal Chicago as the favorite (-124) and Pittsburgh as the underdog (+106) despite being the home team.

Cubs vs Pirates Spread

• The Cubs are 1.5-run road favorites on the runline against the Pirates. The Cubs are +134 to cover, and the Pirates are -162.

Cubs vs Pirates Over/Under

• Cubs versus Pirates, on May 25, has an over/under of 8, with the over being -115 and the under -105.

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Cubs vs Pirates Betting Trends

• The Cubs have been victorious in 20, or 57.1%, of the 35 contests they have been chosen as favorites in this season.
• Chicago has a record of 17-13 when favored by -124 or more this year.
• The Cubs and their opponents have gone over the total this season in 29 of their 52 opportunities.
• The Cubs are 21-31-0 against the spread in their 52 games that had a posted line this season.
• The Pirates have won eight of the 21 games they were the moneyline underdog this season (38.1%).
• Pittsburgh has gone 5-7 when it has played as a moneyline underdog with odds of +106 or longer (41.7%).
• In the 52 games bookmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 26 times (26-24-2).
• The Pirates have a 26-26-0 record against the spread this season.

Cubs Player Leaders

• Nico Hoerner has an OPS of .717, fueled by an OBP of .342 and a team-best slugging percentage of .375 this season. He has a .255 batting average.
• Among all qualified hitters in the majors, he is 75th in batting average, 66th in on-base percentage, and 111th in slugging.
• Michael Busch leads Chicago with an OBP of .360 this season while batting .230 with 35 walks and 21 runs scored. He's slugging .380.
• He is 119th in batting average, 43rd in on-base percentage and 107th in slugging in the majors.
• Dansby Swanson has collected 32 base hits, an OBP of .289 and a slugging percentage of .349 this season.
• Ian Happ has 39 hits, which leads Chicago hitters this season, while batting .214 with 18 extra-base hits.

Pirates Player Leaders

• Brandon Lowe has racked up 47 hits, a team-high for the Pirates. He's batting .260 and slugging .547 with an on-base percentage of .351.
• Including all qualified players, he is 69th in batting average, while his on-base percentage ranks 54th and he is 10th in slugging.
• Bryan Reynolds has eight doubles, two triples, four home runs and 36 walks while batting .251. He's slugging .380 with an on-base percentage of .379.
• He is 80th in batting average, 22nd in on-base percentage and 107th in slugging percentage in MLB.
• Oneil Cruz has put up a team-high .453 slugging percentage.
• Spencer Horwitz has a .381 on-base percentage to pace his team.

Cubs vs Pirates Head to Head

• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/15/2025: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/15/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)

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