Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 8:11 p.m.

In MLB action on Monday, the Chicago Cubs face the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info regarding this game.

Cubs vs Pirates Game Info

• Chicago Cubs (29-24) vs. Pittsburgh Pirates (27-26)
• Date: Monday, May 25, 2026
• Time: 1:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-112) | PIT: (-104)
• Spread: CHC: -1.5 (+146) | PIT: +1.5 (-178)
• Total: 8 -- Over: (-110) | Under: (-110)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Ben Brown (Cubs) - 1-2, 2.09 ERA vs Carmen Mlodzinski (Pirates) - 4-3, 3.96 ERA

The probable pitchers are Ben Brown (1-2) for the Cubs and Carmen Mlodzinski (4-3) for the Pirates. Brown and his team are 2-1-0 ATS this season when he starts. Brown's team won his only start as a favorite this season. The Pirates have a 5-3-0 ATS record in Mlodzinski's eight starts that had a set spread. The Pirates have a 3-2 record in Mlodzinski's five starts this season when they were the underdog on the moneyline.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (52.3%)

Cubs vs Pirates Moneyline

• Chicago is the favorite, -112 on the moneyline, while Pittsburgh is a -104 underdog despite being at home.

Cubs vs Pirates Spread

• The Cubs are 1.5-run road favorites on the runline against the Pirates. The Cubs are +146 to cover, and the Pirates are -178.

Cubs vs Pirates Over/Under

• A combined run total of 8 has been set for Cubs-Pirates on May 25, with the over at -110 and the under at -110.

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Cubs vs Pirates Betting Trends

• The Cubs have won in 20, or 57.1%, of the 35 contests they have been named as odds-on favorites in this year.
• This season Chicago has come away with a win 19 times in 34 chances when named as a favorite of at least -112 on the moneyline.
• The Cubs and their opponents have gone over in 29 of their 52 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 21-31-0 against the spread this season.
• The Pirates have won eight of the 21 games they were the moneyline underdog this season (38.1%).
• Pittsburgh is 7-13 (winning only 35% of its games) when playing as a moneyline underdog of -104 or longer.
• The Pirates have combined with opponents to hit the over on the total 26 times this season for a 26-24-2 record against the over/under.
• The Pirates have a 26-26-0 record ATS this season (covering 50% of the time).

Cubs Player Leaders

• Nico Hoerner has an OPS of .717, fueled by an OBP of .342 and a team-best slugging percentage of .375 this season. He has a .255 batting average.
• Among all qualifying hitters in baseball, his batting average ranks 76th, his on-base percentage ranks 67th, and he is 112th in slugging.
• Michael Busch leads Chicago in OBP (.360) this season, fueled by 43 hits. He's batting .230 while slugging .380.
• His batting average ranks 118th among qualified players, his on-base percentage 43rd, and his slugging percentage 107th.
• Dansby Swanson has 32 hits this season and has a slash line of .189/.289/.349.
• Ian Happ leads Chicago with 39 hits, batting .214 this season with 18 extra-base hits.

Pirates Player Leaders

• Brandon Lowe has racked up 47 hits, a team-high for the Pirates. He's batting .260 and slugging .547 with an on-base percentage of .351.
• He is 70th in batting average, 54th in on-base percentage and 10th in slugging percentage among all qualified hitters in the majors.
• Bryan Reynolds has eight doubles, two triples, four home runs and 36 walks while batting .251. He's slugging .380 with an on-base percentage of .379.
• Including all qualified players, he ranks 81st in batting average, 23rd in on-base percentage and 107th in slugging percentage.
• Oneil Cruz has a .453 slugging percentage, which paces the Pirates.
• Spencer Horwitz's .381 on-base percentage paces his team.

Cubs vs Pirates Head to Head

• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/15/2025: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/15/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)

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