Twins vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 19

Odds updated as of 7:11 p.m.

The Tuesday slate in MLB includes a matchup between the Minnesota Twins and the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this game.

Twins vs Astros Game Info

• Minnesota Twins (22-26) vs. Houston Astros (19-30)
• Date: Tuesday, May 19, 2026
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and SCHN

Twins vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-142) | HOU: (+120)
• Spread: MIN: -1.5 (+155) | HOU: +1.5 (-188)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Twins vs Astros Probable Starting Pitchers

Probable Pitchers: Zebby Matthews (Twins) - 1-0, 0.00 ERA vs Jason Alexander (Astros) - 0-0, 14.21 ERA

This contest's pitching matchup is set, as the Twins will send Zebby Matthews (1-0) to the mound, while Jason Alexander will get the nod for the Astros. Matthews helped his team cover the spread in his only opportunity this season as a starter. Matthews' team won his only start as a favorite this season. Last season Alexander and his team went 8-5-0 against the spread in games he pitched. Alexander and his team finished with a 5-1 record in games he appeared in when they were the underdog on the moneyline a season ago.

Twins vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (57.6%)

Twins vs Astros Moneyline

• The Twins vs Astros moneyline has Minnesota as a -142 favorite, while Houston is a +120 underdog on the road.

Twins vs Astros Spread

• The Astros are +1.5 on the spread (-188 to cover), and Minnesota is +155 to cover the runline.

Twins vs Astros Over/Under

• Twins versus Astros, on May 19, has an over/under of 8.5, with the over being -115 and the under -105.

Bet on Minnesota Twins vs. Houston Astros on FanDuel today!

Twins vs Astros Betting Trends

• The Twins have been victorious in seven, or 46.7%, of the 15 contests they have been chosen as favorites in this season.
• Minnesota has played as a favorite of -142 or more just one time this year and came away with a loss in that game.
• The Twins and their opponents have hit the over in 29 of their 47 games with a total set by oddsmakers this season.
• In 47 games with a line this season, the Twins have a mark of 25-22-0 against the spread.
• The Astros have won 13 of the 32 games they were listed as the moneyline underdog this season (40.6%).
• Houston has gone 5-11 when playing as a moneyline underdog with odds of +120 or longer (31.2%).
• In the 49 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 28 times (28-19-2).
• The Astros have covered only 38.8% of their games this season, going 19-30-0 against the spread.

Twins Player Leaders

• Byron Buxton has 44 hits and an OBP of .319 to go with a slugging percentage of .580. All three of those stats rank first among Minnesota hitters this season. He has a .260 batting average, as well.
• He ranks 71st in batting average, 102nd in on-base percentage, and ninth in slugging among all qualifying hitters in MLB.
• Brooks Lee is hitting .248 with six doubles, five home runs and 11 walks. He's slugging .379 with an on-base percentage of .301.
• He ranks 94th in batting average, 128th in on-base percentage and 108th in slugging in MLB.
• Luke Keaschall has 39 hits this season and has a slash line of .232/.314/.310.
• Keaschall enters this game with four games in a row with at least one hit. In his last five games he is hitting .263 with a triple, a walk and two RBIs.
• Josh Bell is batting .223 with a .286 OBP and 28 RBI for Minnesota this season.
• Bell has safely hit in two straight games. During his last five outings he is hitting .300 with two doubles, two home runs and eight RBIs.

Astros Player Leaders

• Yordan Alvarez has 56 hits with a .427 on-base percentage and a .633 slugging percentage, all club-bests for the Astros. He's batting .316.
• Including all the qualifying hitters in MLB, he ranks 10th in batting average, first in on-base percentage and third in slugging percentage.
• Christian Walker is hitting .267 with 10 doubles, 11 home runs and 18 walks. He's slugging .511 with an on-base percentage of .343.
• He ranks 52nd in batting average, 66th in on-base percentage and 23rd in slugging percentage in the big leagues.
• Isaac Paredes is hitting .250 with seven doubles, four home runs and 16 walks.
• Cam Smith is hitting .199 with six doubles, four home runs and 19 walks.

Twins vs Astros Head to Head

• 5/18/2026: 6-3 MIN (Favorite: Twins, Spread: -1.5, Total: 9.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/15/2025: 2-1 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/14/2025: 3-2 HOU (Favorite: Twins, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/13/2025: 10-3 HOU (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/6/2025: 9-7 HOU (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 4/5/2025: 6-1 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/3/2025: 5-2 HOU (Favorite: Twins, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/7/2024: 3-2 MIN (Favorite: Twins, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/6/2024: 9-3 MIN (Favorite: Twins, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/5/2024: 13-12 HOU (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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