Cardinals vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 19

Odds updated as of 7:11 p.m.

The St. Louis Cardinals versus the Pittsburgh Pirates is on the MLB schedule for Tuesday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Cardinals vs Pirates Game Info

• St. Louis Cardinals (27-19) vs. Pittsburgh Pirates (24-23)
• Date: Tuesday, May 19, 2026
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: Cardinals.TV and SportsNet PT

Cardinals vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: STL: (-116) | PIT: (-102)
• Spread: STL: +1.5 (-200) | PIT: -1.5 (+164)
• Total: 8 -- Over: (-106) | Under: (-114)

Cardinals vs Pirates Probable Starting Pitchers

Probable Pitchers: Matthew Liberatore (Cardinals) - 2-2, 4.40 ERA vs Mitch Keller (Pirates) - 4-2, 3.59 ERA

The Cardinals will give the nod to Matthew Liberatore (2-2, 4.40 ERA), who is eyeing win No. 3 on the season, and the Pirates will counter with Mitch Keller (4-2, 3.59 ERA). Liberatore's team is 5-4-0 against the spread this season in his starts. Liberatore has yet to start a game this season when his team was the moneyline favorite. The Pirates have a 4-4-0 ATS record in Keller's eight starts that had a set spread. The Pirates have been the moneyline underdog in five of Keller's starts this season, and they went 3-2 in those games.

Cardinals vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (52.5%)

Cardinals vs Pirates Moneyline

• The moneyline numbers for Cardinals vs. Pirates reveal St. Louis as the favorite (-116) and Pittsburgh as the underdog (-102) on the road.

Cardinals vs Pirates Spread

• The Pirates are 1.5-run favorites against the spread for this matchup with the Cardinals. The Pirates are +164 to cover, while the Cardinals are -200 to cover as a 1.5-run underdog on the runline.

Cardinals vs Pirates Over/Under

• The Cardinals-Pirates contest on May 19 has been given an over/under of 8 runs. The over is set at -106 and the under at -114.

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Cardinals vs Pirates Betting Trends

• The Cardinals have been favorites in six games this season and have come away with the win three times (50%) in those contests.
• St. Louis has a record of 1-2 when favored by -116 or more this year.
• The Cardinals' games have gone over the total in 19 of their 45 opportunities.
• The Cardinals have posted a record of 28-17-0 against the spread this season.
• The Pirates have compiled a 6-11 record in games they were the underdog on the moneyline (winning 35.3% of those games).
• Pittsburgh is 5-10 (winning only 33.3% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Pirates have played in 46 games with an over/under set, and have combined with opponents to go over the total 24 times (24-21-1).
• The Pirates have put together a 23-23-0 record against the spread this season.

Cardinals Player Leaders

• Jordan Walker leads St. Louis with 52 hits and a team-best slugging percentage of .584. He's batting .301 with an on-base percentage of .371.
• Among qualified hitters in baseball, his batting average ranks 15th, his on-base percentage ranks 30th, and he is eighth in slugging.
• Alec Burleson is hitting .277 with 11 doubles, six home runs and 18 walks, while slugging .441 with an on-base percentage of .340.
• He ranks 38th in batting average, 72nd in on-base percentage and 60th in slugging in MLB.
• Burleson takes a three-game streak with at least one hit into this contest. In his last five games he is hitting .389 with a double and three RBIs.
• JJ Wetherholt has 40 hits this season and has a slash line of .233/.356/.401.
• Ivan Herrera leads St. Louis with an OBP of .395 this season while batting .265 with 29 walks and 25 runs scored.
• Herrera enters this matchup on a six-game hitting streak. In his last 10 games he is batting .317 with two doubles, two walks and three RBIs.

Pirates Player Leaders

• Brandon Lowe is leading the Pirates with 39 hits. He's batting .247 and slugging .551 with an on-base percentage of .344.
• Including all the qualifying hitters in the big leagues, his batting average ranks 95th, his on-base percentage is 64th, and he is 12th in slugging.
• Oneil Cruz leads his team with a .466 slugging percentage. He has a batting average of .259 with an on-base percentage of .324.
• Including all qualifying hitters, he ranks 74th in batting average, 97th in on-base percentage and 46th in slugging percentage.
• Bryan Reynolds has racked up a team-high .384 on-base percentage.
• Spencer Horwitz is hitting .273 with seven doubles, a triple, three home runs and 23 walks.

Cardinals vs Pirates Head to Head

• 4/30/2026: 10-5 STL (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 4/29/2026: 5-4 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/28/2026: 11-7 STL (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 4/27/2026: 4-2 STL (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 8/28/2025: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/27/2025: 2-1 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 8/26/2025: 8-3 PIT (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/25/2025: 7-6 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/2/2025: 5-0 PIT (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/1/2025: 1-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -154, Underdog Moneyline: +130)

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