Twins vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 18

Odds updated as of 7:11 p.m.

The Minnesota Twins are among the MLB teams busy on Monday, versus the Houston Astros.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Twins vs Astros Game Info

• Minnesota Twins (21-26) vs. Houston Astros (19-29)
• Date: Monday, May 18, 2026
• Time: 7:40 p.m. ET
• Venue: Target Field -- Minneapolis, Minnesota
• Coverage: Twins.TV and SCHN

Twins vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: MIN: (-110) | HOU: (-106)
• Spread: MIN: +1.5 (-178) | HOU: -1.5 (+146)
• Total: 9.5 -- Over: (+100) | Under: (-122)

Twins vs Astros Probable Starting Pitchers

Probable Pitchers: Kendry Rojas (Twins) - 1-0, 2.45 ERA vs Tatsuya Imai (Astros) - 1-1, 9.24 ERA

The probable starters are Kendry Rojas (1-0) for the Twins and Tatsuya Imai (1-1) for the Astros. Rojas did not appear in a game when his team was the moneyline favorite last season. The Astros have a 2-2-0 record against the spread in Imai's starts. The Astros were the moneyline underdog for two Imai starts this season -- they lost both.

Twins vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Twins win (51.3%)

Twins vs Astros Moneyline

• Minnesota is a -110 favorite on the moneyline, while Houston is a -106 underdog on the road.

Twins vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Twins. The Astros are +146 to cover, while the Twins are -178 to cover as a 1.5-run underdog on the runline.

Twins vs Astros Over/Under

• The over/under for Twins-Astros on May 18 is 9.5. The over is +100, and the under is -122.

Bet on Minnesota Twins vs. Houston Astros on FanDuel today!

Twins vs Astros Betting Trends

• The Twins have been chosen as favorites in 14 games this year and have walked away with the win six times (42.9%) in those games.
• This year Minnesota has won six of 14 games when listed as at least -110 on the moneyline.
• The Twins and their opponents have gone over in 29 of their 46 games with a total set by sportsbooks this season.
• The Twins are 24-22-0 against the spread in their 46 games with a line set by sportsbooks this season.
• The Astros have gone 13-18 in games they were the underdog on the moneyline (winning 41.9% of those games).
• When it has played as a moneyline underdog with odds of -106 or longer, Houston has a 13-18 record (winning 41.9% of its games).
• The Astros have played in 48 games with an over/under set, and have combined with their opponents to go over the total 28 times (28-18-2).
• The Astros have a 19-29-0 record against the spread this season (covering just 39.6% of the time).

Twins Player Leaders

• Byron Buxton has 44 hits to go with a slugging percentage of .580, both of which rank first among Minnesota hitters this season. He has a .260 batting average and an on-base percentage of .319.
• Among all qualifying batters in the majors, he is 72nd in batting average, 103rd in on-base percentage, and ninth in slugging.
• Ryan Jeffers has 35 hits this season and a team-best OBP of .410. He's batting .294 and slugging .538.
• He ranks 25th in batting average, fourth in on-base percentage and 18th in slugging among qualifying batters.
• Jeffers heads into this game looking to extend his two-game hit streak. In his last five games he is batting .267 with two home runs, five walks and three RBIs.
• Brooks Lee is batting .247 with a .380 slugging percentage and 24 RBI this year.
• Luke Keaschall is batting .232 with a .316 OBP and 15 RBI for Minnesota this season.
• Keaschall has safely hit in three games in a row. During his last five outings he is hitting .278 with a triple and a walk.

Astros Player Leaders

• Yordan Alvarez has accumulated an on-base percentage of .423, a slugging percentage of .638, and has 55 hits, all club-highs for the Astros (while batting .316).
• Including all the qualifying hitters in the majors, his batting average ranks 10th, his on-base percentage ranks second, and he is third in slugging.
• Christian Walker is hitting .263 with 10 doubles, 11 home runs and 18 walks. He's slugging .515 with an on-base percentage of .342.
• His batting average ranks 62nd among all qualified players, his on-base percentage ranks 71st, and he is 23rd in slugging.
• Isaac Paredes is batting .250 with seven doubles, four home runs and 15 walks.
• Cam Smith is hitting .196 with six doubles, four home runs and 19 walks.

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