Tigers vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 2:15 p.m.

The MLB schedule on Sunday includes the Detroit Tigers taking on the Boston Red Sox.

All the info you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Red Sox Game Info

• Detroit Tigers (87-74) vs. Boston Red Sox (88-73)
• Date: Sunday, September 28, 2025
• Time: 3:05 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and FDSDET

Tigers vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-112) | BOS: (-104)
• Spread: DET: -1.5 (+146) | BOS: +1.5 (-178)
• Total: 9 -- Over: (-118) | Under: (-104)

Tigers vs Red Sox Probable Starting Pitchers

Probable Pitchers: Chris Paddack (Tigers) - 5-11, 5.27 ERA vs José De León (Red Sox) - 0-0, 0.00 ERA

The Tigers will give the nod to Chris Paddack (5-11, 5.27 ERA), who is eyeing win No. 6 on the season, and the Red Sox will turn to Jose De Leon. When Paddack starts, his team is 12-14-0 against the spread this season. Paddack's team has won 28.6% of his starts when they are favored on the moneyline (4-10). De León's team was never a moneyline underdog a season ago in games he pitched.

Tigers vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (53.1%)

Tigers vs Red Sox Moneyline

• Detroit is the favorite, -112 on the moneyline, while Boston is a -104 underdog despite being at home.

Tigers vs Red Sox Spread

• The Tigers are 1.5-run road favorites on the runline against the Red Sox. The Tigers are +146 to cover, and the Red Sox are -178.

Tigers vs Red Sox Over/Under

• The over/under for Tigers-Red Sox on Sept. 28 is 9. The over is -118, and the under is -104.

Bet on Detroit Tigers vs. Boston Red Sox on FanDuel today!

Tigers vs Red Sox Betting Trends

• The Tigers have been chosen as favorites in 104 games this year and have walked away with the win 58 times (55.8%) in those games.
• Detroit has a record of 57-46 when favored by -112 or more this year.
• The Tigers' games have gone over the total in 78 of their 154 opportunities.
• The Tigers have posted a record of 71-83-0 against the spread this season.
• The Red Sox have been the moneyline underdog 52 total times this season. They've gone 24-28 in those games.
• Boston is 22-26 (winning 45.8% of its games) when playing as a moneyline underdog of -104 or longer.
• The Red Sox have had an over/under set by bookmakers 160 times, and have combined with opponents to go over the total in 74 of those games (74-79-7).
• The Red Sox have collected an 86-74-0 record ATS this season (covering 53.8% of the time).

Tigers Player Leaders

• Gleyber Torres leads Detroit with an OBP of .358 this season while batting .256 with 85 walks and 79 runs scored. He has a slugging percentage of .387.
• Among qualified hitters in baseball, he ranks 80th in batting average, 21st in on-base percentage, and 120th in slugging.
• Riley Greene leads Detroit with 155 hits and a team-best slugging percentage of .493. He's batting .258 with an on-base percentage of .313.
• He ranks 71st in batting average, 105th in on-base percentage and 20th in slugging in the major leagues.
• Spencer Torkelson is batting .240 with a .456 slugging percentage and 78 RBI this year.
• Zach McKinstry has been key for Detroit with 117 hits, an OBP of .336 plus a slugging percentage of .442.
• McKinstry takes a five-game hitting streak into this game. In his last five games he is batting .429 with two doubles, a home run, a walk and an RBI.

Red Sox Player Leaders

• Jarren Duran has racked up 158 hits with a .333 on-base percentage, leading the Red Sox in both statistics. He's batting .257 and slugging .442.
• Including all the qualified players in the majors, his batting average ranks 74th, his on-base percentage is 63rd, and he is 63rd in slugging.
• Trevor Story's .436 slugging percentage paces his team. He has a batting average of .265 with an on-base percentage of .310.
• He ranks 47th in batting average, 110th in on-base percentage and 69th in slugging percentage in the majors.
• Alex Bregman is hitting .273 with 28 doubles, 18 home runs and 51 walks.
• Ceddanne Rafaela is batting .247 with 33 doubles, four triples, 16 home runs and 27 walks.

Tigers vs Red Sox Head to Head

• 9/27/2025: 2-1 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/26/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 6-5 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 5/13/2025: 10-9 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/12/2025: 14-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/1/2024: 4-1 DET (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/31/2024: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/30/2024: 7-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/2/2024: 8-4 DET (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/1/2024: 6-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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