Tigers vs Red Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 28

Odds updated as of 12:12 p.m.

MLB action on Sunday includes the Detroit Tigers taking on the Boston Red Sox.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Tigers vs Red Sox Game Info

• Detroit Tigers (87-74) vs. Boston Red Sox (88-73)
• Date: Sunday, September 28, 2025
• Time: 3:05 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and FDSDET

Tigers vs Red Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-134) | BOS: (+114)
• Spread: DET: -1.5 (+122) | BOS: +1.5 (-146)
• Total: 9 -- Over: (-118) | Under: (-104)

Tigers vs Red Sox Probable Starting Pitchers

Probable Pitchers: Chris Paddack (Tigers) - 5-11, 5.27 ERA vs TBA (Red Sox)

The Tigers will look to Chris Paddack (5-11), while the Red Sox's starter has not yet been announced. Paddack's team is 12-14-0 against the spread this season in his starts. When Paddack starts a game and his team is the favorite on the moneyline, they have a record of 4-10.

Tigers vs Red Sox Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (53.1%)

Tigers vs Red Sox Moneyline

• The moneyline numbers for Tigers vs. Red Sox reveal Detroit as the favorite (-134) and Boston as the underdog (+114) despite being the home team.

Tigers vs Red Sox Spread

• The Red Sox are +1.5 on the run line against the Tigers. The Red Sox are -146 to cover, and the Tigers are +122.

Tigers vs Red Sox Over/Under

• A combined run total of 9 has been set for Tigers-Red Sox on Sept. 28, with the over at -118 and the under at -104.

Bet on Detroit Tigers vs. Boston Red Sox on FanDuel today!

Tigers vs Red Sox Betting Trends

• The Tigers have been victorious in 58, or 55.8%, of the 104 contests they have been chosen as favorites in this season.
• Detroit has a record of 45-31 when favored by -134 or more this year.
• The Tigers' games have gone over the total in 78 of their 154 opportunities.
• In 154 games with a line this season, the Tigers have a mark of 71-83-0 against the spread.
• The Red Sox have won 24 of the 52 games they were the moneyline underdog this season (46.2%).
• In games it has played as a moneyline underdog with odds of +114 or longer, Boston has a record of 12-18 (40%).
• The Red Sox have played in 160 games with an over/under set, and have combined with opponents to go over the total 74 times (74-79-7).
• The Red Sox are 86-74-0 ATS this season.

Tigers Player Leaders

• Gleyber Torres leads Detroit with an OBP of .358 this season while batting .256 with 85 walks and 79 runs scored. He has a slugging percentage of .387.
• Among qualifying hitters in the majors, his batting average ranks 80th, his on-base percentage ranks 21st, and he is 120th in slugging.
• Riley Greene leads Detroit in slugging percentage (.493) and total hits (155) this season. He's batting .258 with an on-base percentage of .313.
• Among qualifying batters, he is 71st in batting average, 105th in on-base percentage and 20th in slugging percentage.
• Spencer Torkelson has 135 hits this season and has a slash line of .240/.333/.456.
• Zach McKinstry is batting .261 with a .336 OBP and 49 RBI for Detroit this season.
• McKinstry enters this game on a five-game hitting streak. During his last five outings he is hitting .429 with two doubles, a home run, a walk and an RBI.

Red Sox Player Leaders

• Jarren Duran has accumulated 158 hits with a .333 on-base percentage, leading the Red Sox in both statistics. He's batting .257 and slugging .442.
• Including all qualifying hitters in MLB, he ranks 74th in batting average, 63rd in on-base percentage and 63rd in slugging percentage.
• Trevor Story leads his team with a .436 slugging percentage. He has a batting average of .265 with an on-base percentage of .310.
• Including all qualifying hitters, he ranks 47th in batting average, 110th in on-base percentage and 69th in slugging percentage.
• Alex Bregman is batting .273 with 28 doubles, 18 home runs and 51 walks.
• Ceddanne Rafaela is batting .247 with 33 doubles, four triples, 16 home runs and 27 walks.

Tigers vs Red Sox Head to Head

• 9/27/2025: 2-1 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/26/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/14/2025: 6-5 DET (Favorite: Tigers, Spread: -1.5, Total: 7, Favorite Moneyline: -245, Underdog Moneyline: +200)
• 5/13/2025: 10-9 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 5/12/2025: 14-2 DET (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/1/2024: 4-1 DET (Favorite: Tigers, Spread: -1.5, Total: 9.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 8/31/2024: 2-1 DET (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/30/2024: 7-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 6/2/2024: 8-4 DET (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 6/1/2024: 6-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)

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