Tigers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 6:12 p.m.

In MLB action on Tuesday, the Detroit Tigers play the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important information about this matchup.

Tigers vs Pirates Game Info

• Detroit Tigers (60-41) vs. Pittsburgh Pirates (40-61)
• Date: Tuesday, July 22, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSDET

Tigers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-134) | PIT: (+114)
• Spread: DET: -1.5 (+128) | PIT: +1.5 (-154)
• Total: 8 -- Over: (-114) | Under: (-106)

Tigers vs Pirates Probable Starting Pitchers

Probable Pitchers: Casey Mize (Tigers) - 9-3, 3.15 ERA vs Mitch Keller (Pirates) - 3-10, 3.48 ERA

This contest's pitching matchup is set, as the Tigers will send Casey Mize (9-3) to the mound, while Mitch Keller (3-10) will answer the bell for the Pirates. Mize's team is 9-6-0 against the spread this season in his starts. Mize's team has a record of 8-2 this season when he starts and they are the favorite on the moneyline. The Pirates have gone 11-8-0 against the spread when Keller starts. The Pirates are 5-9 in Keller's 14 starts this season that they were the underdog on the moneyline.

Tigers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (58.5%)

Tigers vs Pirates Moneyline

• The Tigers vs Pirates moneyline has Detroit as a -134 favorite, while Pittsburgh is a +114 underdog at home.

Tigers vs Pirates Spread

• The Tigers are 1.5-run road favorites on the runline against the Pirates. The Tigers are +128 to cover, and the Pirates are -154.

Tigers vs Pirates Over/Under

• An over/under of 8 has been set for Tigers-Pirates on July 22, with the over being -114 and the under -106.

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Tigers vs Pirates Betting Trends

• The Tigers have won in 40, or 66.7%, of the 60 contests they have been named as odds-on favorites in this year.
• This season Detroit has come away with a win 31 times in 46 chances when named as a favorite of at least -134 on the moneyline.
• The Tigers' games have gone over the total in 45 of their 95 opportunities.
• The Tigers are 48-47-0 against the spread in their 95 games with a line set by sportsbooks this season.
• The Pirates have been the moneyline underdog 65 total times this season. They've finished 25-40 in those games.
• Pittsburgh has gone 16-33 when it has played as a moneyline underdog with odds of +114 or longer (32.7%).
• The Pirates have played in 94 games with a set over/under, and have combined with their opponents to go over the total 36 times (36-55-3).
• The Pirates have put together a 47-47-0 record ATS this season (covering 50% of the time).

Tigers Player Leaders

• Gleyber Torres leads Detroit in OBP (.388) this season, fueled by 88 hits. He has a .281 batting average and a slugging percentage of .419.
• Among qualified batters in the majors, his batting average ranks 30th, his on-base percentage ranks fifth, and he is 84th in slugging.
• Torres has recorded a base hit in two straight games. In his last five games he is hitting .353 with three walks and an RBI.
• Riley Greene leads Detroit with 106 hits and a team-best slugging percentage of .534. He's batting .277 with an on-base percentage of .327.
• He ranks 43rd in batting average, 80th in on-base percentage and 13th in slugging in the majors.
• Spencer Torkelson has collected 79 base hits, an OBP of .336 and a slugging percentage of .478 this season.
• Zach McKinstry has eight home runs, 32 RBI and a batting average of .276 this season.

Pirates Player Leaders

• Oneil Cruz has racked up 68 hits, a team-best for the Pirates. He's batting .211 and slugging .410 with an on-base percentage of .314.
• Including all qualifying hitters in the majors, his batting average puts him 154th, his on-base percentage ranks 107th, and he is 94th in slugging.
• Andrew McCutchen's .336 on-base percentage paces his team. He has a batting average of .256 while slugging .379.
• He ranks 87th in batting average, 66th in on-base percentage and 130th in slugging percentage in MLB.
• Bryan Reynolds has put up a slugging percentage of .372, a team-high for the Pirates.
• Isiah Kiner-Falefa has 12 doubles, two triples, a home run and 15 walks while hitting .274.

Tigers vs Pirates Head to Head

• 7/21/2025: 3-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/19/2025: 8-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/17/2025: 7-3 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/29/2024: 10-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/29/2024: 8-0 DET (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/9/2024: 5-3 DET (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/8/2024: 7-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/2/2023: 6-3 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/1/2023: 4-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/17/2023: 8-0 PIT (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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