Tigers vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 8:12 a.m.

The MLB's Tuesday slate includes the Detroit Tigers facing the Pittsburgh Pirates.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's everything you need to know.

Tigers vs Pirates Game Info

• Detroit Tigers (60-41) vs. Pittsburgh Pirates (40-61)
• Date: Tuesday, July 22, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and FDSDET

Tigers vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-144) | PIT: (+122)
• Spread: DET: -1.5 (+114) | PIT: +1.5 (-137)
• Total: 8 -- Over: (-110) | Under: (-110)

Tigers vs Pirates Probable Starting Pitchers

Probable Pitchers: Casey Mize (Tigers) - 9-3, 3.15 ERA vs Mitch Keller (Pirates) - 3-10, 3.48 ERA

This contest's pitching matchup is set, as the Tigers will send Casey Mize (9-3) to the mound, while Mitch Keller (3-10) will take the ball for the Pirates. Mize and his team are 9-6-0 ATS this season when he starts. Mize's team is 8-2 this season when he starts and they are the moneyline favorite. The Pirates have gone 11-8-0 against the spread when Keller starts. The Pirates are 5-9 in Keller's 14 starts this season that they were the moneyline underdog.

Tigers vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (58.5%)

Tigers vs Pirates Moneyline

• Pittsburgh is a +122 underdog on the moneyline, while Detroit is a -144 favorite on the road.

Tigers vs Pirates Spread

• The Pirates are +1.5 on the run line against the Tigers. The Pirates are -137 to cover, and the Tigers are +114.

Tigers vs Pirates Over/Under

• The Tigers-Pirates game on July 22 has been given an over/under of 8 runs. The over is set at -110 and the under at -110.

Bet on Detroit Tigers vs. Pittsburgh Pirates on FanDuel today!

Tigers vs Pirates Betting Trends

• The Tigers have been victorious in 40, or 66.7%, of the 60 contests they have been chosen as favorites in this season.
• Detroit has a record of 27-12 in contests when bookmakers favor them by -144 or more on the moneyline.
• The Tigers and their opponents have gone over the total this season in 45 of their 95 opportunities.
• The Tigers have posted a record of 48-47-0 against the spread this season.
• The Pirates have been the underdog on the moneyline 65 total times this season. They've gone 25-40 in those games.
• When it has played as a moneyline underdog with odds of +122 or longer, Pittsburgh has a record of 12-29 (29.3%).
• The Pirates have combined with opponents to go over the total 36 times this season for a 36-55-3 record against the over/under.
• The Pirates have gone 47-47-0 against the spread this season.

Tigers Player Leaders

• Gleyber Torres leads Detroit in OBP (.388) this season, fueled by 88 hits. He has a .281 batting average and a slugging percentage of .419.
• Among qualified hitters in MLB, his batting average ranks 30th, his on-base percentage ranks fifth, and he is 84th in slugging.
• Torres will look for his third straight game with a hit in this matchup. In his last five games he is batting .353 with three walks and an RBI.
• Riley Greene leads Detroit with 106 hits and a team-best slugging percentage of .534. He's batting .277 with an on-base percentage of .327.
• Among qualifying batters, he is 43rd in batting average, 80th in on-base percentage and 13th in slugging percentage.
• Spencer Torkelson is batting .233 with a .478 slugging percentage and 59 RBI this year.
• Zach McKinstry has been key for Detroit with 83 hits, an OBP of .357 plus a slugging percentage of .455.

Pirates Player Leaders

• Oneil Cruz has 68 hits, a team-high for the Pirates. He's batting .211 and slugging .410 with an on-base percentage of .314.
• Including all the qualified hitters in MLB, his batting average ranks 154th, his on-base percentage ranks 107th, and he is 94th in slugging.
• Andrew McCutchen has a .336 on-base percentage to lead his team. He has a batting average of .256 while slugging .379.
• He is currently 87th in batting average, 66th in on-base percentage and 130th in slugging percentage among all qualifying hitters.
• Bryan Reynolds has put up a slugging percentage of .372, a team-high for the Pirates.
• Isiah Kiner-Falefa has 12 doubles, two triples, a home run and 15 walks while hitting .274.

Tigers vs Pirates Head to Head

• 7/21/2025: 3-0 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/19/2025: 8-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 7, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 6/17/2025: 7-3 DET (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 5/29/2024: 10-2 PIT (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/29/2024: 8-0 DET (Favorite: Tigers, Spread: -1.5, Total: 6.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 4/9/2024: 5-3 DET (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/8/2024: 7-4 PIT (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/2/2023: 6-3 DET (Favorite: Tigers, Spread: -1.5, Total: 8.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/1/2023: 4-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/17/2023: 8-0 PIT (Favorite: Tigers, Spread: -1.5, Total: 7.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!