Astros vs Diamondbacks Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 9:12 p.m.

The Arizona Diamondbacks are among the MLB teams playing on Tuesday, versus the Houston Astros.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the most important info about this matchup.

Diamondbacks vs Astros Game Info

• Arizona Diamondbacks (50-51) vs. Houston Astros (58-42)
• Date: Tuesday, July 22, 2025
• Time: 9:40 p.m. ET
• Venue: Chase Field -- Phoenix, Arizona
• Coverage: ARID and SCHN

Diamondbacks vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: ARI: (-116) | HOU: (-102)
• Spread: ARI: +1.5 (-205) | HOU: -1.5 (+168)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Diamondbacks vs Astros Probable Starting Pitchers

Probable Pitchers: Eduardo Rodríguez (Diamondbacks) - 3-6, 5.94 ERA vs Framber Valdez (Astros) - 10-4, 2.75 ERA

The probable pitchers are Eduardo Rodriguez (3-6) for the Diamondbacks and Framber Valdez (10-4) for the Astros. When Rodriguez starts, his team is 5-10-0 against the spread this season. When Rodriguez starts a game and his team is the favorite on the moneyline, they have a record of 4-7. The Astros have a 9-9-0 ATS record in Valdez's 18 starts that had a set spread. The Astros won each of Valdez's three starts this season that they were the underdog on the moneyline.

Diamondbacks vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (54.7%)

Diamondbacks vs Astros Moneyline

• Arizona is the favorite, -116 on the moneyline, while Houston is a -102 underdog on the road.

Diamondbacks vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Diamondbacks. The Astros are +168 to cover, while the Diamondbacks are -205 to cover as a 1.5-run underdog on the runline.

Diamondbacks vs Astros Over/Under

• An over/under of 8.5 has been set for Diamondbacks-Astros on July 22, with the over being -110 and the under -110.

Bet on Arizona Diamondbacks vs. Houston Astros on FanDuel today!

Diamondbacks vs Astros Betting Trends

• The Diamondbacks have come away with 32 wins in the 64 contests they have been listed as the favorites in this season.
• Arizona has a record of 27-27 in contests when oddsmakers favor them by -116 or more on the moneyline.
• The Diamondbacks' games have gone over the total in 52 of their 98 opportunities.
• The Diamondbacks have an against the spread mark of 47-51-0 in 98 games with a line this season.
• The Astros have been the moneyline underdog 31 total times this season. They've gone 19-12 in those games.
• When it has played as a moneyline underdog with odds of -102 or longer, Houston has a 14-10 record (winning 58.3% of its games).
• The Astros have played in 99 games with a set over/under, and have combined with their opponents to go over the total 42 times (42-54-3).
• The Astros have covered 51.5% of their games this season, going 51-48-0 against the spread.

Diamondbacks Player Leaders

• Geraldo Perdomo leads Arizona in OBP (.372) this season, fueled by 99 hits. He has a .270 batting average and a slugging percentage of .417.
• He is 55th in batting average, 17th in on-base percentage, and 87th in slugging among all qualified batters in the majors.
• Eugenio Suarez leads Arizona in total hits (93) this season while batting .257 with 54 extra-base hits. He's slugging .605 with an on-base percentage of .328.
• His batting average ranks 84th among qualified players, his on-base percentage 78th, and his slugging percentage fourth.
• Suarez brings a six-game streak with at least one hit into this contest. In his last 10 games he is batting .306 with a double, eight home runs, five walks and 12 RBIs.
• Josh Naylor has an OPS of .814, fueled by an OBP of .362 and a team-best slugging percentage of .452 this season.
• Naylor has logged a hit or more in two games in a row. In his last five games he is batting .263 with a double and two walks.
• Corbin Carroll is batting .250 with a .326 OBP and 49 RBI for Arizona this season.
• Carroll brings a three-game hitting streak into this game. In his last five games he is hitting .261 with a double, three triples, a walk and two RBIs.

Astros Player Leaders

• Jose Altuve has racked up a team-high .465 slugging percentage. He's batting .278 with an on-base percentage of .337.
• Including all qualified players, he ranks 38th in batting average, while his on-base percentage ranks 65th and he is 44th in slugging.
• Altuve brings a three-game hitting streak into this matchup. In his last five games he is hitting .333 with three doubles, two walks and an RBI.
• Yainer Diaz is batting .239 with 11 doubles, a triple, 13 home runs and 14 walks. He's slugging .394 with an on-base percentage of .271.
• He is 122nd in batting average, 156th in on-base percentage and 110th in slugging percentage in MLB.
• Christian Walker is hitting .230 with 13 doubles, a triple, 13 home runs and 25 walks.
• Cam Smith has 17 doubles, two triples, seven home runs and 27 walks while hitting .269.

Diamondbacks vs Astros Head to Head

• 7/21/2025: 6-3 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/8/2024: 12-6 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/7/2024: 11-5 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 9/6/2024: 8-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 10/1/2023: 8-1 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 9/30/2023: 1-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 9/29/2023: 2-1 HOU (Favorite: Diamondbacks, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/28/2022: 5-2 ARI (Favorite: Astros, Spread: -1.5, Total: 6, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/27/2022: 10-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -225, Underdog Moneyline: +188)
• 4/13/2022: 3-2 ARI (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)

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