Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 6:11 p.m.

Friday's slate in the MLB includes a matchup between the Detroit Tigers and the Cleveland Guardians.

All the information you need to make smart wagers on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Tigers vs Guardians Game Info

• Detroit Tigers (33-18) vs. Cleveland Guardians (27-22)
• Date: Friday, May 23, 2025
• Time: 7:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-116) | CLE: (-102)
• Spread: DET: +1.5 (-192) | CLE: -1.5 (+158)
• Total: 8.5 -- Over: (-118) | Under: (-104)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jackson Jobe (Tigers) - 4-0, 4.12 ERA vs Slade Cecconi (Guardians) - 0-1, 5.40 ERA

This contest's pitching matchup is set, as the Tigers will send Jackson Jobe (4-0) to the mound, while Slade Cecconi (0-1) will answer the bell for the Guardians. Jobe and his team are 7-1-0 ATS this season when he starts. Jobe's team is 2-0 this season when he starts and they're favored on the moneyline. Cecconi has started only one game with a set spread, which the Guardians failed to cover. The Guardians have not been a moneyline underdog when Cecconi starts this season.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (61.1%)

Tigers vs Guardians Moneyline

• Looking at the moneyline for Tigers-Guardians, Detroit is the favorite at -116, and Cleveland is -102 playing on the road.

Tigers vs Guardians Spread

• The Guardians are 1.5-run favorites against the spread for this matchup with the Tigers. The Guardians are +158 to cover, while the Tigers are -192 to cover as a 1.5-run underdog on the runline.

Tigers vs Guardians Over/Under

• The over/under for Tigers-Guardians on May 23 is 8.5. The over is -118, and the under is -104.

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Tigers vs Guardians Betting Trends

• The Tigers have won in 21, or 72.4%, of the 29 contests they have been named as odds-on favorites in this year.
• Detroit has a record of 21-7 when favored by -116 or more this year.
• The Tigers and their opponents have hit the over in 25 of their 50 games with a total set by oddsmakers this season.
• The Tigers are 27-23-0 against the spread in their 50 games with a line set by sportsbooks this season.
• The Guardians have won 50% of the games this season they were the underdog on the moneyline (14-14).
• Cleveland is 10-12 (winning 45.5% of its games) when it has played as a moneyline underdog of -102 or longer.
• The Guardians have combined with opponents to go over the total 22 times this season for a 22-23-2 record against the over/under.
• The Guardians are 22-25-0 against the spread this season.

Tigers Player Leaders

• Spencer Torkelson leads Detroit in total hits (43) this season while batting .244 with 25 extra-base hits. He has an on-base percentage of .355 and a slugging percentage of .523.
• Among all qualified hitters in the majors, his batting average ranks 98th, his on-base percentage ranks 54th, and he is 19th in slugging.
• Riley Greene has hit 12 homers this season while driving in 34 runs. He's batting .281 this season and slugging .521 with an on-base percentage of .337.
• Among all qualified, he ranks 39th in batting average, 70th in on-base percentage and 21st in slugging percentage.
• Gleyber Torres has 39 hits this season and a team-best OBP of .358.
• Kerry Carpenter has 10 home runs, 22 RBI and a batting average of .279 this season.

Guardians Player Leaders

• Jose Ramirez has 54 hits, a team-best for the Guardians. He's batting .307 and slugging .517 with an on-base percentage of .364.
• Including all the qualified players in the big leagues, he is 12th in batting average, 39th in on-base percentage and 22nd in slugging percentage.
• Ramirez takes a 15-game hitting streak into this game. During his last 10 outings he is batting .375 with two doubles, three home runs, three walks and six RBIs.
• Steven Kwan's .373 OBP and .433 slugging percentage both lead his team. He has a batting average of .314.
• Including all qualifying hitters, he is ninth in batting average, 28th in on-base percentage and 67th in slugging percentage.
• Carlos Santana is batting .235 with four doubles, six home runs and 26 walks.
• Kyle Manzardo is batting .212 with five doubles, two triples, 10 home runs and 20 walks.

Tigers vs Guardians Head to Head

• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/9/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/7/2024: 3-0 DET (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/5/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/30/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/29/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/25/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/24/2024: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -144, Underdog Moneyline: +122)

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