Tigers vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 9:11 a.m.

The Detroit Tigers are among the MLB teams busy on Friday, versus the Cleveland Guardians.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Tigers vs Guardians Game Info

• Detroit Tigers (33-18) vs. Cleveland Guardians (27-22)
• Date: Friday, May 23, 2025
• Time: 7:10 p.m. ET
• Venue: Comerica Park -- Detroit, Michigan
• Coverage: FDSDET and CLEG

Tigers vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: DET: (-130) | CLE: (+110)
• Spread: DET: -1.5 (+146) | CLE: +1.5 (-176)
• Total: 8.5 -- Over: (-110) | Under: (-110)

Tigers vs Guardians Probable Starting Pitchers

Probable Pitchers: Jackson Jobe (Tigers) - 4-0, 4.12 ERA vs Slade Cecconi (Guardians) - 0-1, 5.40 ERA

The Tigers will give the ball to Jackson Jobe (4-0, 4.12 ERA), who is eyeing win No. 5 on the season, and the Guardians will counter with Slade Cecconi (0-1, 5.40 ERA). Jobe's team is 7-1-0 against the spread this season in his starts. Jobe's team is 2-0 this season when he starts and they're favored on the moneyline. Cecconi has started just one game with a set spread, which the Guardians failed to cover. The Guardians have yet to be named a moneyline underdog when Cecconi starts this season.

Tigers vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Tigers win (61.1%)

Tigers vs Guardians Moneyline

• Detroit is the favorite, -130 on the moneyline, while Cleveland is a +110 underdog on the road.

Tigers vs Guardians Spread

• The Tigers are favored by 1.5 runs at home against the Guardians. The Tigers are +146 to cover the spread, while the Guardians are -176.

Tigers vs Guardians Over/Under

• A total of 8.5 runs has been set for the Tigers-Guardians game on May 23, with the over available at -110 and the under at -110.

Bet on Detroit Tigers vs. Cleveland Guardians on FanDuel today!

Tigers vs Guardians Betting Trends

• The Tigers have been favorites in 29 games this season and have come away with the win 21 times (72.4%) in those contests.
• Detroit has a record of 19-4 when favored by -130 or more this year.
• The Tigers' games have gone over the total in 25 of their 50 opportunities.
• The Tigers are 27-23-0 against the spread in their 50 games with a line set by sportsbooks this season.
• The Guardians have won 50% of the games this season they were the moneyline underdog (14-14).
• In games it has played as a moneyline underdog with odds of +110 or longer, Cleveland has a record of 4-8 (33.3%).
• In the 47 games oddsmakers have set an over/under for the Guardians, they have combined with opponents to go over the total 22 times (22-23-2).
• The Guardians have a 22-25-0 record against the spread this season (covering 46.8% of the time).

Tigers Player Leaders

• Spencer Torkelson leads Detroit with 43 hits, batting .244 this season with 25 extra-base hits. He has an on-base percentage of .355 and a slugging percentage of .523.
• Among qualifying hitters in the majors, he is 98th in batting average, 54th in on-base percentage, and 18th in slugging.
• Riley Greene leads Detroit in slugging percentage (.521) thanks to 22 extra-base hits. He's batting .281 with an on-base percentage of .337.
• His batting average ranks 39th among qualified players, his on-base percentage 70th, and his slugging percentage 20th.
• Gleyber Torres leads Detroit with an OBP of .358 this season while batting .277 with 16 walks and 20 runs scored.
• Kerry Carpenter has 10 home runs, 22 RBI and a batting average of .279 this season.

Guardians Player Leaders

• Jose Ramirez has racked up 54 hits, a team-high for the Guardians. He's batting .307 and slugging .517 with an on-base percentage of .364.
• Including all qualifying hitters, he is 11th in batting average, while his on-base percentage ranks 39th and he is 22nd in slugging.
• Ramirez takes a 15-game hitting streak into this game. During his last 10 games he is batting .375 with two doubles, three home runs, three walks and six RBIs.
• Steven Kwan's .373 on-base percentage and .433 slugging percentage are both team-highs. He has a batting average of .314.
• He is currently eighth in batting average, 28th in on-base percentage and 67th in slugging percentage among all qualifying hitters.
• Carlos Santana is hitting .235 with four doubles, six home runs and 26 walks.
• Kyle Manzardo is batting .212 with five doubles, two triples, 10 home runs and 20 walks.

Tigers vs Guardians Head to Head

• 5/22/2025: 7-0 CLE (Favorite: Tigers, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/12/2024: 7-3 CLE (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/10/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 6.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 10/9/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 10/7/2024: 3-0 DET (Favorite: Tigers, Spread: -1.5, Total: 6, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 10/5/2024: 7-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/30/2024: 5-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 7/29/2024: 8-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/25/2024: 3-0 DET (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 7/24/2024: 2-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 7, Favorite Moneyline: -144, Underdog Moneyline: +122)

Sign up for FanDuel Sportsbook and FanDuel Daily Fantasy today!