Reds vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 6:12 p.m.

In MLB action on Tuesday, the Cincinnati Reds take on the Washington Nationals.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs Nationals Game Info

• Cincinnati Reds (52-49) vs. Washington Nationals (40-60)
• Date: Tuesday, July 22, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSOH

Reds vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-142) | WSH: (+120)
• Spread: CIN: -1.5 (+114) | WSH: +1.5 (-137)
• Total: 8.5 -- Over: (-122) | Under: (-100)

Reds vs Nationals Probable Starting Pitchers

Probable Pitchers: Chase Burns (Reds) - 0-1, 6.19 ERA vs Brad Lord (Nationals) - 2-5, 3.46 ERA

The Reds will look to Chase Burns (0-1) against the Nationals and Brad Lord (2-5). Burns' team is 1-3-0 against the spread in his starts this season. Burns' team lost his only start as a favorite this season. The Nationals have gone 2-3-0 against the spread when Lord starts. The Nationals are 2-1 in Lord's three starts this season that they were the underdog on the moneyline.

Reds vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (50.3%)

Reds vs Nationals Moneyline

• The moneyline numbers for Reds vs. Nationals reveal Cincinnati as the favorite (-142) and Washington as the underdog (+120) despite being the home team.

Reds vs Nationals Spread

• The Reds are at the Nationals and are favored by 1.5 runs (+114 to cover) on the runline. Washington is -137 to cover.

Reds vs Nationals Over/Under

• An over/under of 8.5 has been set for Reds-Nationals on July 22, with the over being -122 and the under -100.

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Reds vs Nationals Betting Trends

• The Reds have been chosen as favorites in 40 games this year and have walked away with the win 21 times (52.5%) in those games.
• This season Cincinnati has come away with a win nine times in 16 chances when named as a favorite of at least -142 on the moneyline.
• The Reds and their opponents have gone over in 42 of their 95 games with a total set by sportsbooks this season.
• The Reds are 50-45-0 against the spread in their 95 games that had a posted line this season.
• The Nationals have put together a 34-42 record in games they were the underdog on the moneyline (winning 44.7% of those games).
• Washington has a record of 20-31 when playing as a moneyline underdog with odds of +120 or longer (39.2%).
• The Nationals have played in 94 games with a set over/under, and have combined with opponents to go over the total 54 times (54-38-2).
• The Nationals have a 48-46-0 record ATS this season (covering 51.1% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.483) and total hits (107) this season. He's batting .279 with an on-base percentage of .360.
• Among the qualifying hitters in MLB, his batting average ranks 33rd, his on-base percentage ranks 35th, and he is 31st in slugging.
• TJ Friedl leads Cincinnati with an OBP of .364 this season while batting .267 with 47 walks and 58 runs scored. He's slugging .392.
• Among qualifying hitters, his batting average ranks him 65th, his on-base percentage 27th, and his slugging percentage 113th.
• Spencer Steer has 84 hits this season and has a slash line of .249/.307/.396.
• Matt McLain is batting .215 with a .302 OBP and 35 RBI for Cincinnati this season.
• McLain has safely hit in seven straight games. In his last 10 outings he is hitting .300 with two doubles, two home runs, five walks and four RBIs.

Nationals Player Leaders

• James Wood has put up a team-best OBP (.379) and slugging percentage (.526), while leading the Nationals in hits (102, while batting .275).
• Including all qualified players, he ranks 48th in batting average, while his on-base percentage is 10th and he is 14th in slugging.
• C.J. Abrams is batting .279 with 21 doubles, four triples, 13 home runs and 25 walks. He's slugging .477 with an on-base percentage of .344.
• Including all qualified hitters, his batting average puts him 33rd, his on-base percentage ranks 57th, and he is 37th in slugging.
• Luis Garcia is hitting .260 with 20 doubles, seven home runs and 19 walks.
• Nathaniel Lowe has 14 doubles, two triples, 15 home runs and 37 walks while hitting .228.

Reds vs Nationals Head to Head

• 7/21/2025: 10-8 WSH (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/4/2025: 4-1 WSH (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/3/2025: 11-6 WSH (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/21/2024: 5-2 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2024: 5-4 WSH (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2024: 8-5 WSH (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 3/31/2024: 6-5 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 3/30/2024: 7-6 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 3/28/2024: 8-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/6/2023: 6-3 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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