Reds vs Nationals Prediction, Odds, Moneyline, Spread & Over/Under for July 22

Odds updated as of 7:15 a.m.

The Tuesday schedule in MLB includes a matchup between the Cincinnati Reds and the Washington Nationals.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this matchup.

Reds vs Nationals Game Info

• Cincinnati Reds (52-49) vs. Washington Nationals (40-60)
• Date: Tuesday, July 22, 2025
• Time: 6:45 p.m. ET
• Venue: Nationals Park -- Washington, District of Columbia
• Coverage: MASN and FDSOH

Reds vs Nationals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-136) | WSH: (+116)
• Spread: CIN: -1.5 (+118) | WSH: +1.5 (-142)
• Total: 9 -- Over: (-102) | Under: (-120)

Reds vs Nationals Probable Starting Pitchers

Probable Pitchers: Chase Burns (Reds) - 0-1, 6.19 ERA vs Brad Lord (Nationals) - 2-5, 3.46 ERA

The Reds will give the ball to Chase Burns (0-1, 6.19 ERA), who is eyeing win No. 1 on the season, and the Nationals will counter with Brad Lord (2-5, 3.46 ERA). When Burns starts, his team is 1-3-0 against the spread this season. Burns' team lost his only start as a favorite this season. When Lord starts, the Nationals are 2-3-0 against the spread. The Nationals are 2-1 in Lord's three starts this season that they were the underdog on the moneyline.

Reds vs Nationals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Nationals win (50.1%)

Reds vs Nationals Moneyline

• Washington is the underdog, +116 on the moneyline, while Cincinnati is a -136 favorite despite being on the road.

Reds vs Nationals Spread

• The Nationals are +1.5 on the run line against the Reds. The Nationals are -142 to cover, and the Reds are +118.

Reds vs Nationals Over/Under

• Reds versus Nationals on July 22 has an over/under of 9 runs, with the odds on the over -102 and the under set at -120.

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Reds vs Nationals Betting Trends

• The Reds have won in 21, or 52.5%, of the 40 contests they have been named as odds-on favorites in this year.
• Cincinnati has a record of 10-7 when favored by -136 or more this year.
• Contests with the Reds have gone over the total set by oddsmakers in 42 of 95 chances this season.
• In 95 games with a line this season, the Reds have a mark of 50-45-0 against the spread.
• The Nationals have been the moneyline underdog 76 total times this season. They've gone 34-42 in those games.
• When playing as a moneyline underdog with odds of +116 or longer, Washington has a 24-34 record (winning 41.4% of its games).
• The Nationals have played in 94 games with an over/under set, and have combined with their opponents to go over the total 54 times (54-38-2).
• The Nationals have a 48-46-0 record against the spread this season.

Reds Player Leaders

• Elly De La Cruz leads Cincinnati with 107 hits and a team-best slugging percentage of .483. He's batting .279 with an on-base percentage of .360.
• Among all qualifying hitters in baseball, he ranks 33rd in batting average, 35th in on-base percentage, and 31st in slugging.
• TJ Friedl leads Cincinnati in OBP (.364) this season, fueled by 98 hits. He's batting .267 while slugging .392.
• His batting average is 65th among qualified players, his on-base percentage 27th, and his slugging percentage 113th.
• Spencer Steer is batting .249 with a .396 slugging percentage and 41 RBI this year.
• Matt McLain has 11 home runs, 35 RBI and a batting average of .215 this season.
• McLain heads into this game on a seven-game hitting streak. In his last 10 outings he is hitting .300 with two doubles, two home runs, five walks and four RBIs.

Nationals Player Leaders

• James Wood has totaled 102 hits with a .379 on-base percentage and a .526 slugging percentage, all club-highs for the Nationals. He's batting .275.
• Including all qualified players, he ranks 48th in batting average, while his on-base percentage ranks 10th and he is 14th in slugging.
• C.J. Abrams is hitting .279 with 21 doubles, four triples, 13 home runs and 25 walks. He's slugging .477 with an on-base percentage of .344.
• Including all qualified players, he ranks 33rd in batting average, 57th in on-base percentage and 37th in slugging percentage.
• Luis Garcia has 20 doubles, seven home runs and 19 walks while batting .260.
• Nathaniel Lowe is batting .228 with 14 doubles, two triples, 15 home runs and 37 walks.

Reds vs Nationals Head to Head

• 7/21/2025: 10-8 WSH (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/4/2025: 4-1 WSH (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/3/2025: 11-6 WSH (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/21/2024: 5-2 WSH (Favorite: Nationals, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 7/20/2024: 5-4 WSH (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 7/19/2024: 8-5 WSH (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 3/31/2024: 6-5 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 3/30/2024: 7-6 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 3/28/2024: 8-2 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/6/2023: 6-3 WSH (Favorite: Reds, Spread: -1.5, Total: 10.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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