Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 1:12 p.m.

Wednesday's slate in the MLB includes a matchup between the Cincinnati Reds and the St. Louis Cardinals.

All the info you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Reds vs Cardinals Game Info

• Cincinnati Reds (75-76) vs. St. Louis Cardinals (74-78)
• Date: Wednesday, September 17, 2025
• Time: 1:15 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSOH

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-120) | STL: (+102)
• Spread: CIN: -1.5 (+132) | STL: +1.5 (-160)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Brady Singer (Reds) - 13-10, 3.94 ERA vs Andre Pallante (Cardinals) - 6-14, 5.23 ERA

The probable pitchers are Brady Singer (13-10) for the Reds and Andre Pallante (6-14) for the Cardinals. Singer's team is 16-11-0 against the spread this season in his starts. When Singer starts a game and his team is the favorite on the moneyline, they have a record of 6-5. The Cardinals have a 14-15-0 record against the spread in Pallante's starts. The Cardinals have a 7-12 record in Pallante's 19 starts this season when they were the underdog on the moneyline.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (51.1%)

Reds vs Cardinals Moneyline

• The Reds vs Cardinals moneyline has Cincinnati as a -120 favorite, while St. Louis is a +102 underdog at home.

Reds vs Cardinals Spread

• The Reds are 1.5-run road favorites on the runline against the Cardinals. The Reds are +132 to cover, and the Cardinals are -160.

Reds vs Cardinals Over/Under

• An over/under of 8.5 has been set for Reds-Cardinals on Sept. 17, with the over being -104 and the under -118.

Bet on Cincinnati Reds vs. St. Louis Cardinals on FanDuel today!

Reds vs Cardinals Betting Trends

• The Reds have been victorious in 31, or 51.7%, of the 60 contests they have been chosen as favorites in this season.
• Cincinnati has a record of 23-22 in contests when bookmakers favor them by -120 or more on the moneyline.
• The Reds and their opponents have gone over in 57 of their 144 games with a total set by sportsbooks this season.
• The Reds are 74-70-0 against the spread in their 144 games with a line set by sportsbooks this season.
• The Cardinals have won 48.1% of the games this season they were the underdog on the moneyline (39-42).
• In games it has played as a moneyline underdog with odds of +102 or longer, St. Louis has gone 25-34 (42.4%).
• In the 146 games bookmakers have set an over/under for the Cardinals, they have combined with opponents to go over the total 75 times (75-66-5).
• The Cardinals have gone 73-73-0 ATS this season.

Reds Player Leaders

• Elly De La Cruz has 156 hits to go with a slugging percentage of .435, both of which are best among Cincinnati hitters this season. He has a .264 batting average and an on-base percentage of .334.
• Among all qualified hitters in MLB, he ranks 52nd in batting average, 63rd in on-base percentage, and 71st in slugging.
• De La Cruz has hit safely in two straight games. During his last five outings he is hitting .188 with a double and four walks.
• TJ Friedl leads Cincinnati in OBP (.364) this season, fueled by 140 hits. He's batting .259 while slugging .370.
• Among qualifying hitters, his batting average ranks him 72nd, his on-base percentage 15th, and his slugging percentage 131st.
• Spencer Steer has 112 hits this season and has a slash line of .237/.308/.396.
• Austin Hays is batting .266 with a .318 OBP and 64 RBI for Cincinnati this season.

Cardinals Player Leaders

• Alec Burleson has racked up 131 hits with a .451 slugging percentage, both team-best figures for the Cardinals. He's batting .283 and with an on-base percentage of .335.
• Including all the qualified hitters in the majors, he ranks 18th in batting average, 60th in on-base percentage and 58th in slugging percentage.
• Willson Contreras is batting .257 with 31 doubles, a triple, 20 home runs and 44 walks. He's slugging .447 with an on-base percentage of .344.
• He is 77th in batting average, 46th in on-base percentage and 62nd in slugging percentage in the majors.
• Brendan Donovan has a team-best .348 on-base percentage.
• Lars Nootbaar has 23 doubles, a triple, 13 home runs and 58 walks while batting .236.

Reds vs Cardinals Head to Head

• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)

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