Cubs vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 12:12 p.m.

Wednesday's slate in the MLB includes a matchup between the Chicago Cubs and the Pittsburgh Pirates.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Cubs vs Pirates Game Info

• Chicago Cubs (87-64) vs. Pittsburgh Pirates (65-87)
• Date: Wednesday, September 17, 2025
• Time: 12:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: MLB Network, SportsNet PT, and MARQ

Cubs vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CHC: (-142) | PIT: (+120)
• Spread: CHC: -1.5 (+115) | PIT: +1.5 (-138)
• Total: 7.5 -- Over: (-120) | Under: (-102)

Cubs vs Pirates Probable Starting Pitchers

Probable Pitchers: Matthew Boyd (Cubs) - 13-8, 3.05 ERA vs Johan Oviedo (Pirates) - 2-0, 2.81 ERA

The probable starters are Matthew Boyd (13-8) for the Cubs and Johan Oviedo (2-0) for the Pirates. When Boyd starts, his team is 11-17-0 against the spread this season. Boyd's team has a record of 12-10 this season when he starts and they are the favorite on the moneyline. The Pirates have a 5-1-0 record against the spread in Oviedo's starts. The Pirates have been the underdog on the moneyline in six of Oviedo's starts this season, and they went 3-3 in those matchups.

Cubs vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cubs win (58.2%)

Cubs vs Pirates Moneyline

• Chicago is a -142 favorite on the moneyline, while Pittsburgh is a +120 underdog at home.

Cubs vs Pirates Spread

• The Cubs are at the Pirates and are favored by 1.5 runs on the spread. The Cubs are +115 to cover the runline, with the Pirates being -138.

Cubs vs Pirates Over/Under

• The over/under for Cubs-Pirates on Sept. 17 is 7.5. The over is -120, and the under is -102.

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Cubs vs Pirates Betting Trends

• The Cubs have been chosen as favorites in 102 games this year and have walked away with the win 65 times (63.7%) in those games.
• This year Chicago has won 45 of 66 games when listed as at least -142 on the moneyline.
• The Cubs and their opponents have gone over in 67 of their 147 games with a total set by sportsbooks this season.
• The Cubs have posted a record of 69-78-0 against the spread this season.
• The Pirates have won 41% of the games this season they were the underdog on the moneyline (41-59).
• Pittsburgh is 23-40 (winning only 36.5% of its games) when playing as a moneyline underdog of +120 or longer.
• The Pirates have played in 144 games with a set over/under, and have combined with their opponents to go over the total 55 times (55-83-6).
• The Pirates have a 77-67-0 record against the spread this season (covering 53.5% of the time).

Cubs Player Leaders

• Nico Hoerner has an OPS of .752, fueled by an OBP of .351 and a team-best slugging percentage of .401 this season. He has a .301 batting average.
• Among the qualified hitters in the majors, his batting average ranks eighth, his on-base percentage ranks 36th, and he is 102nd in slugging.
• Hoerner will look for his 12th straight game with a hit in this matchup. In his last 10 games he is batting .450 with four doubles, a triple, four walks and three RBIs.
• Pete Crow-Armstrong has 36 doubles, four triples, 29 home runs and 29 walks. He's batting .248 and slugging .485 with an on-base percentage of .290.
• He is 95th in batting average, 137th in on-base percentage and 27th in slugging among qualifying hitters.
• Crow-Armstrong brings a two-game streak with at least one hit into this matchup. During his last five outings he is hitting .150 with a double, a home run, a walk and three RBIs.
• Ian Happ has 127 hits this season and has a slash line of .241/.345/.419.
• Seiya Suzuki is batting .244 with a .324 OBP and 91 RBI for Chicago this season.
• Suzuki heads into this matchup on a six-game hitting streak. During his last 10 games he is hitting .211 with a double, six walks and four RBIs.

Pirates Player Leaders

• Bryan Reynolds has a team-high slugging percentage (.396) and paces the Pirates in hits (134). He's batting .241 and with an on-base percentage of .311.
• Including all the qualifying hitters in MLB, his batting average is 110th, his on-base percentage is 106th, and he is 107th in slugging.
• Oneil Cruz has 18 doubles, three triples, 19 home runs and 63 walks while batting .204. He's slugging .386 with an on-base percentage of .305.
• His batting average is 148th among all qualified players, his on-base percentage ranks 119th, and he is 121st in slugging.
• Andrew McCutchen has racked up a team-best .334 on-base percentage.
• Spencer Horwitz is batting .260 with 22 doubles, nine home runs and 38 walks.

Cubs vs Pirates Head to Head

• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/15/2025: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/15/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/14/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 6/13/2025: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/12/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/1/2025: 8-3 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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