Orioles vs White Sox Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 17

Odds updated as of 2:12 p.m.

Wednesday's slate in the MLB includes a matchup between the Baltimore Orioles and the Chicago White Sox.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Orioles vs White Sox Game Info

• Baltimore Orioles (71-80) vs. Chicago White Sox (57-95)
• Date: Wednesday, September 17, 2025
• Time: 2:10 p.m. ET
• Venue: Rate Field -- Chicago, Illinois
• Coverage: CHSN and MASN2

Orioles vs White Sox Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BAL: (-122) | CHW: (+104)
• Spread: BAL: -1.5 (+134) | CHW: +1.5 (-162)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Orioles vs White Sox Probable Starting Pitchers

Probable Pitchers: Tyler Wells (Orioles) - 1-0, 2.31 ERA vs Martín Pérez (White Sox) - 1-5, 3.27 ERA

The Orioles will give the nod to Tyler Wells (1-0, 2.31 ERA), who is eyeing win No. 2 on the season, and the White Sox will turn to Martin Perez (1-5, 3.27 ERA). Wells has a record of 2-0-0 ATS in two starts with a spread this season. This will be Wells' first game as the moneyline favorite this season. The White Sox have a 6-3-0 record against the spread in Pérez's starts. The White Sox have a 3-6 record in Pérez's nine starts this season when they were the moneyline underdog.

Orioles vs White Sox Moneyline

• Chicago is the underdog, +104 on the moneyline, while Baltimore is a -122 favorite despite being on the road.

Orioles vs White Sox Spread

• The White Sox are hosting the Orioles, and are +1.5 on the runline. The White Sox are +134 to cover the spread, and the Orioles are -162.

Orioles vs White Sox Over/Under

• Orioles versus White Sox, on Sept. 17, has an over/under of 8.5, with the over being -102 and the under -120.

Bet on Baltimore Orioles vs. Chicago White Sox on FanDuel today!

Orioles vs White Sox Betting Trends

• The Orioles have been chosen as favorites in 60 games this year and have walked away with the win 29 times (48.3%) in those games.
• Baltimore has a record of 23-20 when favored by -122 or more this year.
• The Orioles and their opponents have hit the over in 63 of their 148 games with a total set by oddsmakers this season.
• The Orioles are 71-77-0 against the spread in their 148 games with a line set by sportsbooks this season.
• The White Sox have won 53 of the 143 games they were the moneyline underdog this season (37.1%).
• When playing as a moneyline underdog with odds of +104 or longer, Chicago has gone 51-85 (37.5%).
• The White Sox have played in 147 games with an over/under set, and have combined with their opponents to go over the total 68 times (68-71-8).
• The White Sox have covered 57.1% of their games this season, going 84-63-0 against the spread.

Orioles Player Leaders

• Gunnar Henderson leads Baltimore in OBP (.348), slugging percentage (.440) and total hits (146) this season. He has a .272 batting average.
• Among all qualifying batters in baseball, he is 36th in batting average, 40th in on-base percentage, and 65th in slugging.
• Jackson Holliday is hitting .253 with 21 doubles, three triples, 17 home runs and 53 walks. He's slugging .394 with an on-base percentage of .324.
• He is 87th in batting average, 85th in on-base percentage and 113th in slugging among qualified hitters.
• Jordan Westburg has collected 78 base hits, an OBP of .327 and a slugging percentage of .469 this season.
• Colton Cowser is batting .199 with a .267 OBP and 38 RBI for Baltimore this season.

White Sox Player Leaders

• Miguel Vargas has racked up an on-base percentage of .310, a team-high for the White Sox. He's batting .229 and slugging .394.
• Including all qualifying hitters, he is 135th in batting average, while his on-base percentage is 109th and he is 113th in slugging.
• Andrew Benintendi paces his team with 101 hits. He has a batting average of .240 while slugging .431 with an on-base percentage of .306.
• He is 114th in batting average, 117th in on-base percentage and 75th in slugging percentage in MLB.
• Lenyn Sosa has put up a slugging percentage of .426, a team-high for the White Sox.
• Chase Meidroth has 15 doubles, five home runs and 44 walks while hitting .270.

Orioles vs White Sox Head to Head

• 9/16/2025: 8-7 BAL (Favorite: White Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 9/15/2025: 4-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/1/2025: 3-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/31/2025: 4-2 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 5/30/2025: 2-1 BAL (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 9/4/2024: 8-1 CHW (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -375, Underdog Moneyline: +300)
• 9/3/2024: 9-0 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 9/2/2024: 13-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8, Favorite Moneyline: -460, Underdog Moneyline: +360)
• 5/25/2024: 5-3 BAL (Favorite: Orioles, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 5/24/2024: 6-4 BAL (Favorite: Orioles, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)

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