Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 7:11 p.m.

On Tuesday in MLB, the Cincinnati Reds are playing the St. Louis Cardinals.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Cardinals Game Info

• Cincinnati Reds (75-75) vs. St. Louis Cardinals (73-78)
• Date: Tuesday, September 16, 2025
• Time: 7:45 p.m. ET
• Venue: Busch Stadium -- St. Louis, Missouri
• Coverage: FDSMW and FDSOH

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-124) | STL: (+106)
• Spread: CIN: -1.5 (+138) | STL: +1.5 (-166)
• Total: 8 -- Over: (-105) | Under: (-115)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 9-6, 2.79 ERA vs Michael McGreevy (Cardinals) - 6-3, 4.44 ERA

This contest's pitching matchup is set, as the Reds will send Andrew Abbott (9-6) to the mound, while Michael McGreevy (6-3) will take the ball for the Cardinals. Abbott and his team have a record of 14-11-0 against the spread when he starts. When Abbott starts a game and his team is the favorite on the moneyline, they have a record of 9-6. The Cardinals have gone 7-6-0 against the spread when McGreevy starts. The Cardinals are 5-2 in McGreevy's seven starts this season that they were the underdog on the moneyline.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.2%)

Reds vs Cardinals Moneyline

• St. Louis is a +106 underdog on the moneyline, while Cincinnati is a -124 favorite on the road.

Reds vs Cardinals Spread

• The Cardinals are hosting the Reds, and are +1.5 on the runline. The Cardinals are +138 to cover the spread, and the Reds are -166.

Reds vs Cardinals Over/Under

• A combined run total of 8 has been set for Reds-Cardinals on Sept. 16, with the over at -105 and the under at -115.

Bet on Cincinnati Reds vs. St. Louis Cardinals on FanDuel today!

Reds vs Cardinals Betting Trends

• The Reds have come away with 31 wins in the 59 contests they have been listed as the favorites in this season.
• This year Cincinnati has won 19 of 35 games when listed as at least -124 on the moneyline.
• Contests with the Reds have gone over the total set by sportsbooks in 57 of 143 chances this season.
• The Reds have an against the spread mark of 74-69-0 in 143 games with a line this season.
• The Cardinals have been the moneyline underdog 80 total times this season. They've gone 38-42 in those games.
• St. Louis has a 21-32 record (winning just 39.6% of its games) when playing as a moneyline underdog of +106 or longer.
• The Cardinals have had an over/under set by bookmakers 145 times, and have combined with opponents to go over the total in 75 of those games (75-65-5).
• The Cardinals have put together a 72-73-0 record against the spread this season (covering 49.7% of the time).

Reds Player Leaders

• Elly De La Cruz leads Cincinnati in slugging percentage (.435) and total hits (155) this season. He's batting .263 with an on-base percentage of .333.
• Among all qualified hitters, he is 54th in batting average, his on-base percentage ranks 62nd, and he is 71st in slugging.
• TJ Friedl has 140 hits this season and a team-best OBP of .365. He's batting .261 and slugging .372.
• He is 64th in batting average, 14th in on-base percentage and 129th in slugging in the majors.
• Spencer Steer has 112 hits this season and has a slash line of .237/.308/.396.
• Austin Hays has been key for Cincinnati with 97 hits, an OBP of .318 plus a slugging percentage of .459.

Cardinals Player Leaders

• Alec Burleson has put up a team-high slugging percentage (.451) and leads the Cardinals in hits (129). He's batting .281 and with an on-base percentage of .333.
• He is 20th in batting average, 62nd in on-base percentage and 56th in slugging percentage among all qualifying batters in the big leagues.
• Willson Contreras has 31 doubles, a triple, 20 home runs and 44 walks while hitting .257. He's slugging .447 with an on-base percentage of .344.
• Including all qualifying players, his batting average puts him 75th, his on-base percentage ranks 44th, and he is 62nd in slugging.
• Brendan Donovan has put up a team-high .351 on-base percentage.
• Lars Nootbaar is hitting .238 with 23 doubles, a triple, 13 home runs and 58 walks.

Reds vs Cardinals Head to Head

• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/1/2025: 9-1 CIN (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/30/2025: 9-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/30/2025: 6-0 STL (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -154, Underdog Moneyline: +130)

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