Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 23

Odds updated as of 7:12 p.m.

The MLB's Saturday slate includes the Cincinnati Reds taking on the St. Louis Cardinals.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Reds vs Cardinals Game Info

• Cincinnati Reds (26-25) vs. St. Louis Cardinals (29-21)
• Date: Saturday, May 23, 2026
• Time: 7:15 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: FOX

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-112) | STL: (-104)
• Spread: CIN: +1.5 (-182) | STL: -1.5 (+150)
• Total: 9.5 -- Over: (-112) | Under: (-108)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Chase Petty (Reds) - 0-0, 0.00 ERA vs Kyle Leahy (Cardinals) - 5-3, 3.94 ERA

This contest's pitching matchup is set, as the Reds will send Chase Petty to the mound, while Kyle Leahy (5-3) will take the ball for the Cardinals. Petty did not pitch as the moneyline favorite in any games last season. The Cardinals have gone 5-3-0 ATS in Leahy's eight starts with a set spread. The Cardinals have a 4-4 record in Leahy's eight starts this season when they were the moneyline underdog.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Cardinals win (50.7%)

Reds vs Cardinals Moneyline

• Looking at the moneyline for Cardinals-Reds, St. Louis is the underdog at -104, and Cincinnati is -112 playing at home.

Reds vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Reds. The Cardinals are +150 to cover, while the Reds are -182 to cover as a 1.5-run underdog on the runline.

Reds vs Cardinals Over/Under

• An over/under of 9.5 has been set for Reds-Cardinals on May 23, with the over being -112 and the under -108.

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Reds vs Cardinals Betting Trends

• The Reds have come away with nine wins in the 17 contests they have been listed as the favorites in this season.
• Cincinnati has a record of 8-7 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Reds and their opponents have gone over in 30 of their 49 games with a total set by sportsbooks this season.
• The Reds have an against the spread mark of 29-20-0 in 49 games with a line this season.
• The Cardinals have won 24 of the 41 games they were the underdog on the moneyline this season (58.5%).
• St. Louis has a 21-17 record (winning 55.3% of its games) when it has played as a moneyline underdog of -104 or longer.
• The Cardinals have played in 49 games with an over/under set, and have combined with their opponents to go over the total 21 times (21-24-4).
• The Cardinals have put together a 30-19-0 record ATS this season.

Reds Player Leaders

• Sal Stewart has nine doubles, 12 home runs and 27 walks while hitting .259. He has an on-base percentage of .347 and a slugging percentage of .492.
• Among qualified hitters, he ranks 71st in batting average, his on-base percentage ranks 61st, and he is 28th in slugging.
• Elly De La Cruz leads Cincinnati in OBP (.350), slugging percentage (.515) and total hits (58) this season. He's batting .284.
• Among qualified hitters, his batting average ranks him 34th, his on-base percentage 55th, and his slugging percentage 20th.
• Spencer Steer is batting .270 with a .443 slugging percentage and 18 RBI this year.
• JJ Bleday is batting .288 with a .396 OBP and 20 RBI for Cincinnati this season.

Cardinals Player Leaders

• Jordan Walker has racked up 55 hits, a team-high for the Cardinals. He's batting .293 and slugging .569 with an on-base percentage of .362.
• Including all qualified hitters in the majors, he ranks 22nd in batting average, 38th in on-base percentage and sixth in slugging percentage.
• Alec Burleson's .468 slugging percentage leads his team. He has a batting average of .295 with an on-base percentage of .364.
• His batting average ranks 18th among all qualified players, his on-base percentage ranks 35th, and he is 44th in slugging.
• Ivan Herrera has a team-best .395 on-base percentage.
• JJ Wetherholt has five doubles, nine home runs and 26 walks while batting .238.

Reds vs Cardinals Head to Head

• 5/23/2026: 8-1 STL (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/17/2025: 6-2 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/16/2025: 3-0 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/15/2025: 11-6 CIN (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 8/31/2025: 7-4 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/30/2025: 4-2 STL (Favorite: Reds, Spread: -1.5, Total: 8, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/29/2025: 7-5 STL (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 6/22/2025: 4-1 CIN (Favorite: Reds, Spread: -1.5, Total: 9.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 6-5 STL (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 6/20/2025: 6-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)

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