Reds vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 1:12 a.m.

In MLB action on Friday, the Cincinnati Reds take on the St. Louis Cardinals.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Reds vs Cardinals Game Info

• Cincinnati Reds (26-24) vs. St. Louis Cardinals (28-21)
• Date: Friday, May 22, 2026
• Time: 6:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and Cardinals.TV

Reds vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-116) | STL: (-102)
• Spread: CIN: +1.5 (-188) | STL: -1.5 (+155)
• Total: 9.5 -- Over: (-105) | Under: (-115)

Reds vs Cardinals Probable Starting Pitchers

Probable Pitchers: Chris Paddack (Reds) - 0-5, 7.07 ERA vs Kyle Leahy (Cardinals) - 5-3, 3.94 ERA

This contest's pitching matchup is set, as the Reds will send Chris Paddack (0-5) to the mound, while Kyle Leahy (5-3) will answer the bell for the Cardinals. When Paddack starts, his team is 1-6-0 against the spread this season. Paddack's team is 0-2 this season when he starts and they're favored on the moneyline. The Cardinals have a 5-3-0 ATS record in Leahy's eight starts with a set spread. The Cardinals have been the underdog on the moneyline in eight of Leahy's starts this season, and they went 4-4 in those matchups.

Reds vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Reds win (55.2%)

Reds vs Cardinals Moneyline

• St. Louis is the underdog, -102 on the moneyline, while Cincinnati is a -116 favorite at home.

Reds vs Cardinals Spread

• The Cardinals are 1.5-run favorites against the spread for this matchup with the Reds. The Cardinals are +155 to cover, while the Reds are -188 to cover as a 1.5-run underdog on the runline.

Reds vs Cardinals Over/Under

• The Reds-Cardinals contest on May 22 has been given an over/under of 9.5 runs. The over is set at -105 and the under at -115.

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Reds vs Cardinals Betting Trends

• The Reds have been favorites in 16 games this season and have come away with the win nine times (56.2%) in those contests.
• This year Cincinnati has won seven of 13 games when listed as at least -116 on the moneyline.
• The Reds and their opponents have hit the over in 30 of their 48 games with a total set by oddsmakers this season.
• The Reds have posted a record of 29-19-0 against the spread this season.
• The Cardinals have been the underdog on the moneyline 40 total times this season. They've finished 23-17 in those games.
• St. Louis has gone 20-17 when playing as a moneyline underdog with odds of -102 or longer (54.1%).
• The Cardinals have played in 48 games with an over/under set, and have combined with their opponents to go over the total 21 times (21-23-4).
• The Cardinals have a 29-19-0 record against the spread this season (covering 60.4% of the time).

Reds Player Leaders

• Sal Stewart is hitting .265 with nine doubles, 12 home runs and 27 walks. He has an on-base percentage of .353 and a slugging percentage of .503.
• Among all qualifying hitters in baseball, he is 62nd in batting average, 54th in on-base percentage, and 24th in slugging.
• Stewart hopes to build on a four-game hitting streak in this matchup. In his last five games he is hitting .529 with a double, two home runs, four walks and four RBIs.
• Elly De La Cruz leads Cincinnati with 58 hits and an OBP of .356, plus a team-best slugging percentage of .525. He's batting .290.
• He is 25th in batting average, 51st in on-base percentage and 18th in slugging in MLB.
• Spencer Steer has 47 hits this season and has a slash line of .273/.340/.448.
• Steer enters this matchup with 11 games in a row with at least one hit. During his last 10 outings he is hitting .349 with three doubles, a home run, three walks and six RBIs.
• JJ Bleday is batting .299 with a .402 OBP and 20 RBI for Cincinnati this season.
• Bleday heads into this matchup on a two-game hitting streak. During his last five outings he is hitting .158 with a double, a walk and an RBI.

Cardinals Player Leaders

• Jordan Walker has put up a slugging percentage of .563 and has 54 hits, both team-best numbers for the Cardinals. He's batting .295 and with an on-base percentage of .366.
• Including all qualifying players in MLB, he ranks 19th in batting average, 36th in on-base percentage and eighth in slugging percentage.
• Alec Burleson is slugging .468 to pace his team. He has a batting average of .290 with an on-base percentage of .359.
• Including all qualifying hitters, he ranks 25th in batting average, 43rd in on-base percentage and 46th in slugging percentage.
• JJ Wetherholt is hitting .239 with five doubles, nine home runs and 25 walks.
• Ivan Herrera's .386 OBP leads his team.

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