Blue Jays vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 1:12 a.m.

The Friday schedule in MLB includes a matchup between the Toronto Blue Jays and the Pittsburgh Pirates.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this matchup.

Blue Jays vs Pirates Game Info

• Toronto Blue Jays (23-27) vs. Pittsburgh Pirates (26-24)
• Date: Friday, May 22, 2026
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SN1 and SportsNet PT

Blue Jays vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-162) | PIT: (+136)
• Spread: TOR: -1.5 (+134) | PIT: +1.5 (-162)
• Total: 8 -- Over: (-106) | Under: (-114)

Blue Jays vs Pirates Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 3-3, 3.61 ERA vs Bubba Chandler (Pirates) - 1-5, 5.14 ERA

The probable starters are Kevin Gausman (3-3) for the Blue Jays and Bubba Chandler (1-5) for the Pirates. Gausman and his team are 5-5-0 ATS this season when he starts. When Gausman starts a game and his team is the favorite on the moneyline, they have a record of 4-3. The Pirates have a 4-5-0 ATS record in Chandler's nine starts with a set spread. The Pirates were named the moneyline underdog for five Chandler starts this season -- they lost each time.

Blue Jays vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (52.7%)

Blue Jays vs Pirates Moneyline

• Looking at the moneyline for Blue Jays-Pirates, Toronto is the favorite at -162, and Pittsburgh is +136 playing on the road.

Blue Jays vs Pirates Spread

• The Blue Jays are favored by 1.5 runs at home versus the Pirates. The Blue Jays are +134 to cover the spread, while the Pirates are -162.

Blue Jays vs Pirates Over/Under

• A total of 8 runs has been set for the Blue Jays-Pirates contest on May 22, with the over available at -106 and the under at -114.

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Blue Jays vs Pirates Betting Trends

• The Blue Jays have been favorites in 28 games this season and have come away with the win 16 times (57.1%) in those contests.
• This season Toronto has been victorious four times in eight chances when named as a favorite of at least -162 on the moneyline.
• The Blue Jays and their opponents have gone over in 25 of their 49 games with a total set by sportsbooks this season.
• The Blue Jays have posted a record of 23-26-0 against the spread this season.
• The Pirates have won seven of the 19 games they were the moneyline underdog this season (36.8%).
• When playing as a moneyline underdog with odds of +136 or longer, Pittsburgh has gone 1-2 (33.3%).
• In the 49 games bookmakers have set an over/under for the Pirates, they have combined with opponents to go over the total 26 times (26-22-1).
• The Pirates have collected a 25-24-0 record against the spread this season (covering 51% of the time).

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .374 this season while batting .283 with 25 walks and 29 runs scored. He has a slugging percentage of .372.
• Among qualifying batters in MLB, he ranks 37th in batting average, 26th in on-base percentage, and 118th in slugging.
• Guerrero will look for his third straight game with a hit in this matchup. In his last five games he is hitting .313 with a home run, three walks and three RBIs.
• Ernie Clement has an OPS of .748, fueled by an OBP of .320 and a team-best slugging percentage of .429 this season. He's batting .296.
• Among qualifying hitters, his batting average ranks him 18th, his on-base percentage 98th, and his slugging percentage 67th.
• Clement has picked up at least one hit in four games in a row. During his last five outings he is hitting .375 with three doubles, a home run, a walk and four RBIs.
• Daulton Varsho leads Toronto in total hits (47) this season, and 17 of those have gone for extra bases.
• Varsho has logged a hit or more in six games in a row. In his last 10 outings he is batting .342 with four doubles, a triple, a home run, three walks and seven RBIs.
• Kazuma Okamoto has been key for Toronto with 39 hits, an OBP of .302 plus a slugging percentage of .413.

Pirates Player Leaders

• Brandon Lowe has put up 44 hits, a team-best for the Pirates. He's batting .256 and slugging .558 with an on-base percentage of .348.
• Including all qualifying hitters, he is 75th in batting average, while his on-base percentage is 63rd and he is 10th in slugging.
• Lowe hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .286 with two doubles, a home run, a walk and an RBI.
• Oneil Cruz is slugging .455 to lead his team. He has a batting average of .257 with an on-base percentage of .324.
• Including all qualifying hitters, he ranks 73rd in batting average, 92nd in on-base percentage and 51st in slugging percentage.
• Bryan Reynolds is hitting .244 with eight doubles, two triples, four home runs and 34 walks.
• Spencer Horwitz has a .384 on-base percentage to pace his team.

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