Blue Jays vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:12 p.m.

The Toronto Blue Jays are among the MLB teams in action on Friday, up against the Pittsburgh Pirates.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Blue Jays vs Pirates Game Info

• Toronto Blue Jays (23-27) vs. Pittsburgh Pirates (26-24)
• Date: Friday, May 22, 2026
• Time: 7:07 p.m. ET
• Venue: Rogers Centre -- Toronto, Ontario
• Coverage: SN1 and SportsNet PT

Blue Jays vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TOR: (-164) | PIT: (+138)
• Spread: TOR: -1.5 (+132) | PIT: +1.5 (-160)
• Total: 8 -- Over: (-110) | Under: (-110)

Blue Jays vs Pirates Probable Starting Pitchers

Probable Pitchers: Kevin Gausman (Blue Jays) - 3-3, 3.61 ERA vs Bubba Chandler (Pirates) - 1-5, 5.14 ERA

The Blue Jays will give the nod to Kevin Gausman (3-3, 3.61 ERA), who is eyeing win No. 4 on the season, and the Pirates will counter with Bubba Chandler (1-5, 5.14 ERA). Gausman's team is 5-5-0 against the spread in his starts this season. Gausman's team has won 57.1% of his starts when they are favored on the moneyline (4-3). The Pirates have a 4-5-0 record against the spread in Chandler's starts. The Pirates were the moneyline underdog for five Chandler starts this season -- they lost every time.

Blue Jays vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Blue Jays win (52.9%)

Blue Jays vs Pirates Moneyline

• Looking at the moneyline for Pirates-Blue Jays, Pittsburgh is the underdog at +138, and Toronto is -164 playing at home.

Blue Jays vs Pirates Spread

• The Blue Jays are favored by 1.5 runs at home versus the Pirates. The Blue Jays are +132 to cover the spread, while the Pirates are -160.

Blue Jays vs Pirates Over/Under

• A combined run total of 8 has been set for Blue Jays-Pirates on May 22, with the over at -110 and the under at -110.

Bet on Toronto Blue Jays vs. Pittsburgh Pirates on FanDuel today!

Blue Jays vs Pirates Betting Trends

• The Blue Jays have come away with 16 wins in the 28 contests they have been listed as the favorites in this season.
• Toronto has a record of 4-4 when favored by -164 or more this year.
• The Blue Jays and their opponents have gone over the total this season in 25 of their 49 opportunities.
• In 49 games with a line this season, the Blue Jays have a mark of 23-26-0 against the spread.
• The Pirates have been the underdog on the moneyline 19 total times this season. They've gone 7-12 in those games.
• Pittsburgh has gone 1-2 in games it has played as a moneyline underdog with odds of +138 or longer (33.3%).
• The Pirates have played in 49 games with an over/under set, and have combined with opponents to go over the total 26 times (26-22-1).
• The Pirates have a 25-24-0 record ATS this season (covering 51% of the time).

Blue Jays Player Leaders

• Vladimir Guerrero Jr. leads Toronto with an OBP of .374 this season while batting .283 with 25 walks and 29 runs scored. He has a slugging percentage of .372.
• Among qualifying hitters in the majors, he ranks 35th in batting average, 26th in on-base percentage, and 118th in slugging.
• Guerrero hopes to build on a two-game hitting streak in this matchup. During his last five outings he is batting .313 with a home run, three walks and three RBIs.
• Ernie Clement has hit three homers this season while driving in 16 runs. He's batting .296 this season and slugging .429 with an on-base percentage of .320.
• He is 18th in batting average, 97th in on-base percentage and 67th in slugging in the majors.
• Clement brings a four-game streak with at least one hit into this matchup. In his last five games he is batting .375 with three doubles, a home run, a walk and four RBIs.
• Daulton Varsho has 47 hits and is batting .276 this season.
• Varsho heads into this game with six games in a row with at least one hit. In his last 10 games he is batting .342 with four doubles, a triple, a home run, three walks and seven RBIs.
• Kazuma Okamoto has been key for Toronto with 39 hits, an OBP of .302 plus a slugging percentage of .413.

Pirates Player Leaders

• Brandon Lowe has accumulated 44 hits, a team-best for the Pirates. He's batting .256 and slugging .558 with an on-base percentage of .348.
• Including all qualified hitters, he is 75th in batting average, while his on-base percentage ranks 63rd and he is ninth in slugging.
• Lowe hopes to build on a four-game hitting streak in this matchup. In his last five games he is batting .286 with two doubles, a home run, a walk and an RBI.
• Oneil Cruz's .455 slugging percentage paces his team. He has a batting average of .257 with an on-base percentage of .324.
• He ranks 73rd in batting average, 92nd in on-base percentage and 51st in slugging percentage in the majors.
• Bryan Reynolds has eight doubles, two triples, four home runs and 34 walks while batting .244.
• Spencer Horwitz leads his team with a .384 OBP.

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