Red Sox vs Twins Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:12 p.m.

The MLB's Friday slate includes the Boston Red Sox facing the Minnesota Twins.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital info about this game.

Red Sox vs Twins Game Info

• Boston Red Sox (22-27) vs. Minnesota Twins (23-27)
• Date: Friday, May 22, 2026
• Time: 7:10 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and Twins.TV

Red Sox vs Twins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-148) | MIN: (+126)
• Spread: BOS: -1.5 (+155) | MIN: +1.5 (-188)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Red Sox vs Twins Probable Starting Pitchers

Probable Pitchers: Payton Tolle (Red Sox) - 2-2, 2.05 ERA vs Connor Prielipp (Twins) - 1-2, 2.88 ERA

The probable starters are Payton Tolle (2-2) for the Red Sox and Connor Prielipp (1-2) for the Twins. When Tolle starts, his team is 1-4-0 against the spread this season. Tolle's team is 1-1 this season when he starts and they're favored on the moneyline. The Twins have a 3-2-0 record against the spread in Prielipp's starts. The Twins are 1-4 in Prielipp's five starts this season that they were the moneyline underdog.

Red Sox vs Twins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (54.7%)

Red Sox vs Twins Moneyline

• The Red Sox vs Twins moneyline has Boston as a -148 favorite, while Minnesota is a +126 underdog on the road.

Red Sox vs Twins Spread

• The Red Sox are hosting the Twins and are favored by 1.5 runs (+155 to cover) on the runline. Minnesota is -188 to cover.

Red Sox vs Twins Over/Under

• A total of 7.5 runs has been set for the Red Sox-Twins game on May 22, with the over available at -105 and the under at -115.

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Red Sox vs Twins Betting Trends

• The Red Sox have won in 15, or 48.4%, of the 31 contests they have been named as odds-on favorites in this year.
• This season Boston has come away with a win two times in seven chances when named as a favorite of at least -148 on the moneyline.
• Contests with the Red Sox have gone over the total set by bookmakers in 21 of 49 chances this season.
• The Red Sox are 20-29-0 against the spread in their 49 games that had a posted line this season.
• The Twins have been the underdog on the moneyline 32 total times this season. They've gone 14-18 in those games.
• When it has played as a moneyline underdog with odds of +126 or longer, Minnesota has a 7-5 record (winning 58.3% of its games).
• The Twins have played in 49 games with a set over/under, and have combined with opponents to go over the total 29 times (29-19-1).
• The Twins have covered 53.1% of their games this season, going 26-23-0 ATS.

Red Sox Player Leaders

• Willson Contreras has 45 hits and an OBP of .369, both of which rank first among Boston hitters this season. He has a .269 batting average and a slugging percentage of .497.
• Among qualifying hitters in baseball, his batting average ranks 52nd, his on-base percentage ranks 31st, and he is 26th in slugging.
• Contreras will look for his sixth straight game with a hit in this matchup. During his last five outings he is hitting .450 with a double, a triple, two home runs and seven RBIs.
• Wilyer Abreu has hit six homers this season while driving in 19 runs. He's batting .292 this season and slugging .438 with an on-base percentage of .359.
• He is 21st in batting average, 43rd in on-base percentage and 61st in slugging in the majors.
• Abreu has picked up at least one hit in two straight games. In his last five games he is hitting .217 with a double.
• Jarren Duran has collected 34 base hits, an OBP of .266 and a slugging percentage of .362 this season.
• Duran has logged a hit or more in two games in a row. In his last five games he is batting .368 with three doubles, a triple, two home runs, four walks and six RBIs.
• Ceddanne Rafaela has four home runs, 19 RBI and a batting average of .287 this season.
• Rafaela has hit safely in five straight games. During his last five outings he is hitting .368 with four doubles and two walks.

Twins Player Leaders

• Byron Buxton has racked up 46 hits with a .320 on-base percentage and a .576 slugging percentage, all club-highs for the Twins. He's batting .260.
• Including all the qualifying hitters in the majors, his batting average ranks 71st, his on-base percentage is 97th, and he is fifth in slugging.
• Brooks Lee has six doubles, a triple, five home runs and 11 walks while hitting .248. He's slugging .388 with an on-base percentage of .299.
• He ranks 90th in batting average, 127th in on-base percentage and 99th in slugging percentage in the majors.
• Luke Keaschall is batting .227 with eight doubles, a triple, a home run and 19 walks.
• Josh Bell is hitting .231 with eight doubles, five home runs and 15 walks.

Red Sox vs Twins Head to Head

• 4/15/2026: 9-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 4/14/2026: 6-0 MIN (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/13/2026: 13-6 MIN (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/30/2025: 13-1 BOS (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/29/2025: 8-5 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 7/28/2025: 5-4 MIN (Favorite: Twins, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 5/4/2025: 5-4 MIN (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 5/3/2025: 4-3 MIN (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 5/2/2025: 6-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/22/2024: 9-3 BOS (Favorite: Twins, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)

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