Phillies vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for May 22

Odds updated as of 6:12 p.m.

The Philadelphia Phillies versus the Cleveland Guardians is on the MLB schedule for Friday.

We've got you covered, in terms of the vital information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Guardians Game Info

• Philadelphia Phillies (25-25) vs. Cleveland Guardians (30-22)
• Date: Friday, May 22, 2026
• Time: 6:40 p.m. ET
• Venue: Citizens Bank Park -- Philadelphia, Pennsylvania
• Coverage: NBCS-PH and CleGuardians.TV

Phillies vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-178) | CLE: (+150)
• Spread: PHI: -1.5 (+126) | CLE: +1.5 (-152)
• Total: 6.5 -- Over: (-118) | Under: (-104)

Phillies vs Guardians Probable Starting Pitchers

Probable Pitchers: Cristopher Sanchez (Phillies) - 5-2, 1.82 ERA vs Gavin Williams (Guardians) - 6-3, 3.67 ERA

This contest's pitching matchup is set, as the Phillies will send Cristopher Sanchez (5-2) to the mound, while Gavin Williams (6-3) will get the nod for the Guardians. Sanchez's team is 5-5-0 against the spread in his starts this season. Sanchez's team has a record of 7-3 this season when he starts and they are the favorite on the moneyline. The Guardians have a 6-3-0 ATS record in Williams' nine starts with a set spread. The Guardians were the moneyline underdog for two Williams starts this season -- they split the games.

Phillies vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (65.9%)

Phillies vs Guardians Moneyline

• Philadelphia is a -178 favorite on the moneyline, while Cleveland is a +150 underdog on the road.

Phillies vs Guardians Spread

• The Guardians are +1.5 on the run line against the Phillies. The Guardians are -152 to cover, and the Phillies are +126.

Phillies vs Guardians Over/Under

• The over/under for Phillies-Guardians on May 22 is 6.5. The over is -118, and the under is -104.

Bet on Philadelphia Phillies vs. Cleveland Guardians on FanDuel today!

Phillies vs Guardians Betting Trends

• The Phillies have been favorites in 36 games this season and have come away with the win 20 times (55.6%) in those contests.
• Philadelphia has a record of 8-2 when favored by -178 or more this year.
• The Phillies' games have gone over the total in 24 of their 50 opportunities.
• In 50 games with a line this season, the Phillies have a mark of 15-35-0 against the spread.
• The Guardians have been the moneyline underdog 22 total times this season. They've finished 12-10 in those games.
• Cleveland has a record of 3-2 when playing as a moneyline underdog with odds of +150 or longer (60%).
• The Guardians have played in 49 games with an over/under set, and have combined with opponents to go over the total 25 times (25-24-0).
• The Guardians have collected a 26-23-0 record against the spread this season (covering 53.1% of the time).

Phillies Player Leaders

• Bryce Harper leads Philadelphia in OBP (.359) this season, fueled by 48 hits. He has a .267 batting average and a slugging percentage of .528.
• He is 59th in batting average, 43rd in on-base percentage, and 16th in slugging among all qualified hitters in baseball.
• Kyle Schwarber leads Philadelphia with 41 hits. He is batting .230 this season and has 29 extra-base hits. He's also slugging .624 with an on-base percentage of .357.
• Among all qualified batters, he ranks 120th in batting average, 48th in on-base percentage and second in slugging percentage.
• Trea Turner has collected 48 base hits, an OBP of .294 and a slugging percentage of .358 this season.
• Turner has picked up a hit in seven straight games. In his last 10 outings he is hitting .216 with two doubles, a home run, four walks and four RBIs.
• Brandon Marsh has an OPS of .814, fueled by an OBP of .350 and a team-best slugging percentage of .464 this season.

Guardians Player Leaders

• Jose Ramirez has 11 doubles, eight home runs and 37 walks while hitting .236. He's slugging .419 with an on-base percentage of .361.
• Including all the qualifying hitters in the big leagues, his batting average is 112th, his on-base percentage is 39th, and he is 78th in slugging.
• Chase DeLauter is batting .267 with 10 doubles, a triple, seven home runs and 24 walks. He's slugging .459 with an on-base percentage of .354.
• Including all qualifying players, he ranks 59th in batting average, 52nd in on-base percentage and 49th in slugging percentage.
• Brayan Rocchio has a team-best OBP (.376) and slugging percentage (.420).
• Angel Martinez's 41 hits lead his team.

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