Reds vs Astros Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 1:12 p.m.

MLB action on Sunday includes the Cincinnati Reds playing the Houston Astros.

We've got you covered, in terms of the most important info about this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Reds vs Astros Game Info

• Cincinnati Reds (21-19) vs. Houston Astros (16-24)
• Date: Sunday, May 10, 2026
• Time: 1:40 p.m. ET
• Venue: Great American Ball Park -- Cincinnati, Ohio
• Coverage: Reds.TV and SCHN

Reds vs Astros Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: CIN: (-112) | HOU: (-104)
• Spread: CIN: +1.5 (-184) | HOU: -1.5 (+152)
• Total: 9.5 -- Over: (+102) | Under: (-124)

Reds vs Astros Probable Starting Pitchers

Probable Pitchers: Andrew Abbott (Reds) - 1-2, 5.13 ERA vs Kai-Wei Teng (Astros) - 1-2, 2.35 ERA

This contest's pitching matchup is set, as the Reds will send Andrew Abbott (1-2) to the mound, while Kai-Wei Teng (1-2) will get the nod for the Astros. Abbott and his team have a record of 5-3-0 against the spread when he starts. Abbott's team won his only start as a favorite this season. Teng has started only one game with a set spread, which the Astros failed to cover. The Astros were the underdog on the moneyline for one Teng start this season -- they lost.

Reds vs Astros Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (53.5%)

Reds vs Astros Moneyline

• Houston is a -104 underdog on the moneyline, while Cincinnati is a -112 favorite at home.

Reds vs Astros Spread

• The Astros are 1.5-run favorites against the spread for this matchup with the Reds. The Astros are +152 to cover, while the Reds are -184 to cover as a 1.5-run underdog on the runline.

Reds vs Astros Over/Under

• An over/under of 9.5 has been set for Reds-Astros on May 10, with the over being +102 and the under -124.

Bet on Cincinnati Reds vs. Houston Astros on FanDuel today!

Reds vs Astros Betting Trends

• The Reds have won in seven, or 58.3%, of the 12 contests they have been named as odds-on favorites in this year.
• Cincinnati has a record of 6-4 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Reds and their opponents have gone over in 23 of their 38 games with a total set by sportsbooks this season.
• The Reds have posted a record of 23-15-0 against the spread this season.
• The Astros have a 10-13 record in games they were the underdog on the moneyline (winning 43.5% of those games).
• Houston has a 10-13 record (winning 43.5% of its games) when playing as a moneyline underdog of -104 or longer.
• In the 40 games bookmakers have set an over/under for the Astros, they have combined with opponents to go over the total 26 times (26-13-1).
• The Astros have a 16-24-0 record ATS this season (covering 40% of the time).

Reds Player Leaders

• Sal Stewart has six doubles, 10 home runs and 20 walks while batting .245. He has an on-base percentage of .329 and a slugging percentage of .483.
• He is 103rd in batting average, 94th in on-base percentage, and 36th in slugging among qualifying hitters in baseball.
• Stewart will look for his fourth straight game with a hit in this contest. In his last five games he is hitting .200 with a home run, two walks and an RBI.
• Elly De La Cruz has 44 hits and an OBP of .345 to go with a slugging percentage of .516. All three of those stats are tops among Cincinnati hitters this season. He's batting .277.
• He ranks 44th in batting average, 66th in on-base percentage and 27th in slugging in the majors.
• De La Cruz has picked up at least one hit in three games in a row. In his last five games he is batting .227 with two doubles and four RBIs.
• Spencer Steer has collected 32 base hits, an OBP of .324 and a slugging percentage of .434 this season.
• Nathaniel Lowe has six home runs, 16 RBI and a batting average of .259 this season.

Astros Player Leaders

• Yordan Alvarez has put up an on-base percentage of .432, a slugging percentage of .660, and has 48 hits, all club-highs for the Astros (while batting .327).
• Including all the qualifying hitters in MLB, he is seventh in batting average, first in on-base percentage and third in slugging percentage.
• Christian Walker is hitting .288 with nine doubles, nine home runs and 15 walks. He's slugging .534 with an on-base percentage of .360.
• His batting average is 36th among all qualified players, his on-base percentage is 52nd, and he is 17th in slugging.
• Jose Altuve is hitting .243 with 10 doubles, three home runs and 17 walks.
• Isaac Paredes has seven doubles, three home runs and 14 walks while batting .256.

Reds vs Astros Head to Head

• 5/9/2026: 3-1 CIN (Favorite: Reds, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 5/8/2026: 10-0 HOU (Favorite: Reds, Spread: -1.5, Total: 9, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 5/11/2025: 6-0 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/10/2025: 13-9 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 5/9/2025: 3-0 HOU (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 9/5/2024: 1-0 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 9/4/2024: 12-5 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/2/2024: 5-3 CIN (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 6/18/2023: 9-7 CIN (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 6/17/2023: 10-3 CIN (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -120, Underdog Moneyline: +102)

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