Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for May 10

Odds updated as of 4:11 p.m.

Sunday's slate in the MLB includes a matchup between the San Diego Padres and the St. Louis Cardinals.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Cardinals Game Info

• San Diego Padres (23-16) vs. St. Louis Cardinals (23-16)
• Date: Sunday, May 10, 2026
• Time: 4:10 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and Cardinals.TV

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-132) | STL: (+112)
• Spread: SD: -1.5 (+158) | STL: +1.5 (-192)
• Total: 8.5 -- Over: (-102) | Under: (-120)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Walker Buehler (Padres) - 2-2, 5.64 ERA vs Kyle Leahy (Cardinals) - 4-3, 4.93 ERA

The Padres will give the nod to Walker Buehler (2-2) against the Cardinals and Kyle Leahy (4-3). Buehler's team is 5-2-0 against the spread in his starts this season. Buehler's team has been victorious in 33.3% of the games he's started as the moneyline favorite with a record of 1-2. The Cardinals have a 4-3-0 ATS record in Leahy's seven starts that had a set spread. The Cardinals are 4-3 in Leahy's seven starts this season that they were the moneyline underdog.

Padres vs Cardinals Moneyline

• The moneyline numbers for Padres vs. Cardinals reveal San Diego as the favorite (-132) and St. Louis as the underdog (+112) on the road.

Padres vs Cardinals Spread

• The Cardinals are at +1.5 on the runline against the Padres. The Cardinals are -192 to cover the spread, and the Padres are +158.

Padres vs Cardinals Over/Under

• An over/under of 8.5 has been set for Padres-Cardinals on May 10, with the over being -102 and the under -120.

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Padres vs Cardinals Betting Trends

• The Padres have been favorites in 23 games this season and have come away with the win 13 times (56.5%) in those contests.
• This season San Diego has been victorious 10 times in 18 chances when named as a favorite of at least -132 on the moneyline.
• The Padres and their opponents have gone over the total this season in 16 of their 39 opportunities.
• The Padres have an against the spread mark of 22-17-0 in 39 games with a line this season.
• The Cardinals are 21-14 in games they were the underdog on the moneyline (winning 60% of those games).
• When it has played as a moneyline underdog with odds of +112 or longer, St. Louis has a 12-11 record (winning 52.2% of its games).
• The Cardinals have had an over/under set by oddsmakers 39 times, and have combined with opponents to go over the total in 18 of those games (18-18-3).
• The Cardinals are 24-15-0 ATS this season.

Padres Player Leaders

• Xander Bogaerts leads San Diego with 36 hits and an OBP of .338, plus a team-best slugging percentage of .428. He's batting .261.
• Among qualifying hitters, he ranks 66th in batting average, his on-base percentage ranks 79th, and he is 67th in slugging.
• Manny Machado has four doubles, six home runs and 21 walks. He's batting .197 and slugging .364 with an on-base percentage of .303.
• Among all qualifying players, he ranks 160th in batting average, 133rd in on-base percentage and 126th in slugging percentage.
• Jackson Merrill is batting .224 with a .361 slugging percentage and 18 RBI this year.
• Ramon Laureano has been key for San Diego with 29 hits, an OBP of .302 plus a slugging percentage of .397.

Cardinals Player Leaders

• Jordan Walker has a team-best slugging percentage (.566) and leads the Cardinals in hits (43). He's batting .301 and with an on-base percentage of .380.
• Including all qualifying hitters, he is 22nd in batting average, while his on-base percentage is 26th and he is 10th in slugging.
• Alec Burleson is batting .267 with 10 doubles, six home runs and 18 walks. He's slugging .453 with an on-base percentage of .343.
• His batting average ranks 58th among all qualified players, his on-base percentage ranks 72nd, and he is 51st in slugging.
• JJ Wetherholt is batting .235 with five doubles, seven home runs and 20 walks.
• Ivan Herrera leads his team with a .416 on-base percentage.

Padres vs Cardinals Head to Head

• 5/9/2026: 4-2 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 5/8/2026: 6-0 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 5/7/2026: 2-1 STL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 8/3/2025: 7-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/2/2025: 8-5 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)

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