Red Sox vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 7:12 p.m.

The Boston Red Sox versus the Tampa Bay Rays is on the MLB schedule for Sunday.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Red Sox vs Rays Game Info

• Boston Red Sox (85-70) vs. Tampa Bay Rays (75-80)
• Date: Sunday, September 21, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and NESN

Red Sox vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-130) | TB: (+110)
• Spread: BOS: -1.5 (+128) | TB: +1.5 (-154)
• Total: 7.5 -- Over: (-115) | Under: (-105)

Red Sox vs Rays Probable Starting Pitchers

Probable Pitchers: Connelly Early (Red Sox) - 1-0, 0.87 ERA vs Joe Boyle (Rays) - 1-3, 4.64 ERA

This contest's pitching matchup is set, as the Red Sox will send Connelly Early (1-0) to the mound, while Joe Boyle (1-3) will get the nod for the Rays. Early has a record of 1-1-0 ATS in two starts with a spread this season. Early's team lost his only start as a favorite this season. The Rays are 2-5-0 against the spread when Boyle starts. The Rays have been the underdog on the moneyline in seven of Boyle's starts this season, and they went 2-5 in those matchups.

Red Sox vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (51.6%)

Red Sox vs Rays Moneyline

• Looking at the moneyline for Red Sox-Rays, Boston is the favorite at -130, and Tampa Bay is +110 playing at home.

Red Sox vs Rays Spread

• The Rays are hosting the Red Sox, and are +1.5 on the runline. The Rays are +128 to cover the spread, and the Red Sox are -154.

Red Sox vs Rays Over/Under

• A total of 7.5 runs has been set for the Red Sox-Rays game on Sept. 21, with the over available at -115 and the under at -105.

Bet on Boston Red Sox vs. Tampa Bay Rays on FanDuel today!

Red Sox vs Rays Betting Trends

• The Red Sox have been favorites in 97 games this season and have come away with the win 56 times (57.7%) in those contests.
• This year Boston has won 32 of 57 games when listed as at least -130 on the moneyline.
• The Red Sox and their opponents have hit the over in 72 of their 154 games with a total set by oddsmakers this season.
• The Red Sox have an against the spread mark of 82-72-0 in 154 games with a line this season.
• The Rays have gone 30-43 in games they were listed as the moneyline underdog (winning 41.1% of those games).
• Tampa Bay has a 15-19 record (winning 44.1% of its games) when it has played as a moneyline underdog of +110 or longer.
• The Rays have played in 150 games with an over/under set, and have combined with opponents to go over the total 66 times (66-76-8).
• The Rays are 66-84-0 ATS this season.

Red Sox Player Leaders

• Jarren Duran leads Boston in OBP (.336), slugging percentage (.450) and total hits (155) this season. He has a .261 batting average.
• Among qualifying hitters in baseball, he is 62nd in batting average, 56th in on-base percentage, and 57th in slugging.
• Duran has hit safely in two straight games. During his last five outings he is hitting .333 with a home run, three walks and two RBIs.
• Trevor Story has hit 25 homers this season while driving in 95 runs. He's batting .265 this season and slugging .441 with an on-base percentage of .312.
• His batting average ranks 52nd among qualified players, his on-base percentage 107th, and his slugging percentage 64th.
• Alex Bregman has collected 114 base hits, an OBP of .359 and a slugging percentage of .470 this season.
• Bregman has picked up a hit in three games in a row. In his last five games he is batting .211 with a home run, four walks and two RBIs.
• Ceddanne Rafaela is batting .244 with a .289 OBP and 61 RBI for Boston this season.
• Rafaela takes a two-game hitting streak into this game. During his last five outings he is hitting .368 with a double, a walk and an RBI.

Rays Player Leaders

• Junior Caminero has totaled 149 hits, a team-high for the Rays. He's batting .258 and slugging .535 with an on-base percentage of .301.
• Including all the qualifying players in MLB, his batting average ranks 72nd, his on-base percentage ranks 122nd, and he is eighth in slugging.
• Yandy Diaz paces his team with a .367 on-base percentage, and has a club-best .489 slugging percentage. He has a batting average of .302.
• Including all qualifying hitters, he is seventh in batting average, 13th in on-base percentage and 24th in slugging percentage.
• Brandon Lowe is hitting .258 with 18 doubles, 29 home runs and 36 walks.
• Chandler Simpson is batting .297 with 14 doubles, three triples and 20 walks.

Red Sox vs Rays Head to Head

• 9/20/2025: 6-3 BOS (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/19/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/13/2025: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/12/2025: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/11/2025: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/11/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 10-8 TB (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/16/2025: 1-0 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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