Red Sox vs Rays Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 21

Odds updated as of 4:14 a.m.

The Boston Red Sox are among the MLB teams busy on Sunday, up against the Tampa Bay Rays.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Red Sox vs Rays Game Info

• Boston Red Sox (85-70) vs. Tampa Bay Rays (75-80)
• Date: Sunday, September 21, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and NESN

Red Sox vs Rays Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-120) | TB: (+102)
• Spread: BOS: -1.5 (+146) | TB: +1.5 (-176)
• Total: 8 -- Over: (-110) | Under: (-110)

Red Sox vs Rays Probable Starting Pitchers

Probable Pitchers: Connelly Early (Red Sox) - 1-0, 0.87 ERA vs Joe Boyle (Rays) - 1-3, 4.64 ERA

This contest's pitching matchup is set, as the Red Sox will send Connelly Early (1-0) to the mound, while Joe Boyle (1-3) will get the nod for the Rays. Early has a record of 1-1-0 ATS in two starts with a spread this season. Early's team lost his only start as a favorite this season. When Boyle starts, the Rays have gone 2-5-0 against the spread. The Rays have been the moneyline underdog in seven of Boyle's starts this season, and they went 2-5 in those games.

Red Sox vs Rays Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (52.7%)

Red Sox vs Rays Moneyline

• Looking at the moneyline for Red Sox-Rays, Boston is the favorite at -120, and Tampa Bay is +102 playing at home.

Red Sox vs Rays Spread

• The Red Sox are 1.5-run road favorites on the runline against the Rays. The Red Sox are +146 to cover, and the Rays are -176.

Red Sox vs Rays Over/Under

• A total of 8 runs has been set for the Red Sox-Rays contest on Sept. 21, with the over available at -110 and the under at -110.

Bet on Boston Red Sox vs. Tampa Bay Rays on FanDuel today!

Red Sox vs Rays Betting Trends

• The Red Sox have been favorites in 97 games this season and have come away with the win 56 times (57.7%) in those contests.
• This season Boston has been victorious 40 times in 70 chances when named as a favorite of at least -120 on the moneyline.
• The Red Sox and their opponents have gone over in 72 of their 154 games with a total set by sportsbooks this season.
• The Red Sox have posted a record of 82-72-0 against the spread this season.
• The Rays are 30-43 in games they were the underdog on the moneyline (winning 41.1% of those games).
• Tampa Bay has a 22-27 record (winning 44.9% of its games) when playing as a moneyline underdog of +102 or longer.
• The Rays have played in 150 games with a set over/under, and have combined with their opponents to go over the total 66 times (66-76-8).
• The Rays have covered 44% of their games this season, going 66-84-0 against the spread.

Red Sox Player Leaders

• Jarren Duran leads Boston with 155 hits and an OBP of .336, plus a team-best slugging percentage of .450. He's batting .261.
• Among all qualified hitters in MLB, he is 61st in batting average, 56th in on-base percentage, and 57th in slugging.
• Duran will look for his third straight game with a hit in this contest. During his last five outings he is batting .333 with a home run, three walks and two RBIs.
• Trevor Story has hit 25 homers this season while driving in 95 runs. He's batting .265 this season and slugging .441 with an on-base percentage of .312.
• His batting average ranks 50th among qualified players, his on-base percentage 106th, and his slugging percentage 62nd.
• Alex Bregman has collected 114 base hits, an OBP of .359 and a slugging percentage of .470 this season.
• Bregman heads into this game with three games in a row with at least one hit. In his last five games he is hitting .211 with a home run, four walks and two RBIs.
• Ceddanne Rafaela has 16 home runs, 61 RBI and a batting average of .244 this season.
• Rafaela brings a two-game hitting streak into this game. During his last five outings he is batting .368 with a double, a walk and an RBI.

Rays Player Leaders

• Junior Caminero has racked up 149 hits, a team-best for the Rays. He's batting .258 and slugging .535 with an on-base percentage of .301.
• Including all qualifying players, he ranks 70th in batting average, while his on-base percentage ranks 121st and he is eighth in slugging.
• Yandy Diaz has a .367 on-base percentage while slugging .489. Both pace his team. He has a batting average of .302.
• His batting average is seventh among all qualified players, his on-base percentage ranks 13th, and he is 23rd in slugging.
• Brandon Lowe is hitting .258 with 18 doubles, 29 home runs and 36 walks.
• Chandler Simpson has 14 doubles, three triples and 20 walks while batting .297.

Red Sox vs Rays Head to Head

• 9/20/2025: 6-3 BOS (Favorite: Rays, Spread: -1.5, Total: 8, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 9/19/2025: 11-7 BOS (Favorite: Red Sox, Spread: -1.5, Total: 6.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/13/2025: 4-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 7/12/2025: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 7/11/2025: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/10/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/11/2025: 4-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 6/10/2025: 3-1 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 6/9/2025: 10-8 TB (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 4/16/2025: 1-0 BOS (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -130, Underdog Moneyline: +110)

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