Red Sox vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 10:12 p.m.

In MLB action on Monday, the Boston Red Sox take on the Cleveland Guardians.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Red Sox vs Guardians Game Info

• Boston Red Sox (76-62) vs. Cleveland Guardians (68-67)
• Date: Monday, September 1, 2025
• Time: 1:35 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and CLEG

Red Sox vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-152) | CLE: (+128)
• Spread: BOS: -1.5 (+136) | CLE: +1.5 (-164)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Red Sox vs Guardians Probable Starting Pitchers

Probable Pitchers: TBA (Red Sox) vs Parker Messick (Guardians) - 1-0, 0.00 ERA

Messick (1-0) will get the nod for the Guardians. As of this writing, there's been no pitching decision announced by the Red Sox. Messick has started two games with set spreads, and the Guardians went 1-1-0. The Guardians were the moneyline underdog for one Messick start this season -- they lost.

Red Sox vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (67.4%)

Red Sox vs Guardians Moneyline

• Cleveland is the underdog, +128 on the moneyline, while Boston is a -152 favorite at home.

Red Sox vs Guardians Spread

• The Guardians are at +1.5 on the runline against the Red Sox. The Guardians are -164 to cover the spread, and the Red Sox are +136.

Red Sox vs Guardians Over/Under

• An over/under of 8.5 has been set for Red Sox-Guardians on Sept. 1, with the over being -105 and the under -115.

Bet on Boston Red Sox vs. Cleveland Guardians on FanDuel today!

Red Sox vs Guardians Betting Trends

• The Red Sox have won in 50, or 58.8%, of the 85 contests they have been named as odds-on favorites in this year.
• Boston has a record of 18-12 when favored by -152 or more this year.
• The Red Sox and their opponents have gone over in 65 of their 137 games with a total set by sportsbooks this season.
• The Red Sox are 74-63-0 against the spread in their 137 games with a line set by sportsbooks this season.
• The Guardians have been the moneyline underdog 75 total times this season. They've gone 32-43 in those games.
• In games it has played as a moneyline underdog with odds of +128 or longer, Cleveland has gone 12-14 (46.2%).
• The Guardians have played in 132 games with an over/under set, and have combined with their opponents to go over the total 59 times (59-68-5).
• The Guardians are 69-63-0 against the spread this season.

Red Sox Player Leaders

• Jarren Duran has 138 hits and an OBP of .337 to go with a slugging percentage of .451. All three of those stats are tops among Boston hitters this season. He has a .260 batting average, as well.
• Among all qualifying hitters in baseball, he is 73rd in batting average, 62nd in on-base percentage, and 63rd in slugging.
• Duran has recorded a base hit in four straight games. During his last five outings he is batting .333 with a double, a home run, two walks and three RBIs.
• Trevor Story is batting .256 with 23 doubles, 22 home runs and 29 walks. He's slugging .428 with an on-base percentage of .303.
• He ranks 85th in batting average, 124th in on-base percentage and 80th in slugging in the major leagues.
• Ceddanne Rafaela is batting .250 with a .422 slugging percentage and 56 RBI this year.
• Alex Bregman has been key for Boston with 99 hits, an OBP of .372 plus a slugging percentage of .496.

Guardians Player Leaders

• Jose Ramirez has racked up a team-high OBP (.357) and slugging percentage (.500), and leads the Guardians in hits (139, while batting .283).
• Including all qualifying hitters in the majors, his batting average puts him 24th, his on-base percentage is 28th, and he is 20th in slugging.
• Steven Kwan leads his team with a .377 slugging percentage. He has a batting average of .270 with an on-base percentage of .329.
• Including all qualified hitters, his batting average places him 45th, his on-base percentage ranks 81st, and he is 133rd in slugging.
• Kyle Manzardo has 14 doubles, two triples, 23 home runs and 41 walks while batting .233.
• Angel Martinez is batting .225 with 21 doubles, a triple, 10 home runs and 16 walks.

Red Sox vs Guardians Head to Head

• 4/27/2025: 13-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 4/26/2025: 7-3 BOS (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/26/2025: 5-4 CLE (Favorite: Red Sox, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/25/2024: 6-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 4/24/2024: 8-0 BOS (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 4/23/2024: 4-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 4/18/2024: 5-4 CLE (Favorite: Guardians, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 4/17/2024: 2-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 4/16/2024: 10-7 CLE (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 4/15/2024: 6-0 CLE (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -154, Underdog Moneyline: +130)

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