Astros vs Angels Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 10:12 p.m.

The Houston Astros are among the MLB squads playing on Monday, versus the Los Angeles Angels.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Astros vs Angels Game Info

• Houston Astros (75-62) vs. Los Angeles Angels (64-72)
• Date: Monday, September 1, 2025
• Time: 2:10 p.m. ET
• Venue: Daikin Park -- Houston, Texas
• Coverage: SCHN and FDSW

Astros vs Angels Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: HOU: (-146) | LAA: (+124)
• Spread: HOU: -1.5 (+136) | LAA: +1.5 (-164)
• Total: 8.5 -- Over: (-115) | Under: (-105)

Astros vs Angels Probable Starting Pitchers

Probable Pitchers: Luis Garcia (Astros) - 0-0, 0.00 ERA vs Yusei Kikuchi (Angels) - 6-9, 3.68 ERA

This contest's pitching matchup is set, as the Astros will send Luis Garcia to the mound, while Yusei Kikuchi (6-9) will take the ball for the Angels. Garcia did not pitch as the moneyline favorite last season. The Angels are 16-12-0 ATS in Kikuchi's 28 starts with a set spread. The Angels have been the moneyline underdog in 17 of Kikuchi's starts this season, and they went 6-11 in those matchups.

Astros vs Angels Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Astros win (58%)

Astros vs Angels Moneyline

• Looking at the moneyline for Angels-Astros, Los Angeles is the underdog at +124, and Houston is -146 playing at home.

Astros vs Angels Spread

• The Astros are favored by 1.5 runs at home versus the Angels. The Astros are +136 to cover the spread, while the Angels are -164.

Astros vs Angels Over/Under

• Astros versus Angels on Sept. 1 has an over/under of 8.5 runs, with the odds on the over -115 and the under set at -105.

Bet on Houston Astros vs. Los Angeles Angels on FanDuel today!

Astros vs Angels Betting Trends

• The Astros have come away with 47 wins in the 89 contests they have been listed as the favorites in this season.
• This season Houston has come away with a win 19 times in 35 chances when named as a favorite of at least -146 on the moneyline.
• The Astros and their opponents have hit the over in 60 of their 136 games with a total set by oddsmakers this season.
• The Astros are 67-69-0 against the spread in their 136 games that had a posted line this season.
• The Angels have been the underdog on the moneyline 101 total times this season. They've finished 46-55 in those games.
• In games it has played as a moneyline underdog with odds of +124 or longer, Los Angeles has gone 28-27 (50.9%).
• In the 134 games oddsmakers have set an over/under for the Angels, they have combined with opponents to go over the total 71 times (71-58-5).
• The Angels have a 73-61-0 record against the spread this season.

Astros Player Leaders

• Jose Altuve leads Houston in slugging percentage (.451) thanks to 44 extra-base hits. He has a .273 batting average and an on-base percentage of .335.
• Among qualified batters in the majors, he ranks 39th in batting average, 66th in on-base percentage, and 63rd in slugging.
• Jeremy Pena has 128 hits and an OBP of .364, both of which lead the Astros this season. He's batting .305 and slugging .471.
• His batting average is fourth among qualified players, his on-base percentage 21st, and his slugging percentage 40th.
• Christian Walker has collected 117 base hits, an OBP of .300 and a slugging percentage of .410 this season.
• Yainer Diaz is batting .253 with a .284 OBP and 55 RBI for Houston this season.

Angels Player Leaders

• Taylor Ward is hitting .228 with 30 doubles, two triples, 30 home runs and 67 walks. He's slugging .476 with an on-base percentage of .318.
• Including all qualified hitters, he ranks 143rd in batting average, while his on-base percentage ranks 99th and he is 37th in slugging.
• Zach Neto's 123 hits and .486 slugging percentage both lead his team. He has a batting average of .265 with an on-base percentage of .321.
• He is 61st in batting average, 95th in on-base percentage and 30th in slugging percentage in the majors.
• Jo Adell is batting .233 with 16 doubles, a triple, 30 home runs and 29 walks.
• Mike Trout has a .361 on-base percentage to pace his team.

Astros vs Angels Head to Head

• 8/31/2025: 3-0 LAA (Favorite: Astros, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/30/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/29/2025: 2-0 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 6/22/2025: 8-7 HOU (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 6/21/2025: 9-1 LAA (Favorite: Angels, Spread: -1.5, Total: 8.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/20/2025: 3-2 HOU (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 4/13/2025: 7-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/12/2025: 4-1 LAA (Favorite: Astros, Spread: -1.5, Total: 9, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 4/11/2025: 14-3 HOU (Favorite: Astros, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/22/2024: 9-8 LAA (Favorite: Astros, Spread: -1.5, Total: 8, Favorite Moneyline: -275, Underdog Moneyline: +225)

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