Red Sox vs Athletics Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 6:14 p.m.

The MLB slate on Tuesday includes the Boston Red Sox facing the Athletics.

Before checking out the MLB betting lines on FanDuel Sportsbook, we've got you covered, in terms of the vital information regarding this game.

Red Sox vs Athletics Game Info

• Boston Red Sox (82-68) vs. Athletics (70-80)
• Date: Tuesday, September 16, 2025
• Time: 6:45 p.m. ET
• Venue: Fenway Park -- Boston, Massachusetts
• Coverage: NESN and NBCS-CA

Red Sox vs Athletics Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: BOS: (-162) | OAK: (+136)
• Spread: BOS: -1.5 (+126) | OAK: +1.5 (-152)
• Total: 8.5 -- Over: (-114) | Under: (-106)

Red Sox vs Athletics Probable Starting Pitchers

Probable Pitchers: Connelly Early (Red Sox) - 1-0, 0.00 ERA vs Jeffrey Springs (Athletics) - 10-11, 4.28 ERA

The Red Sox will look to Connelly Early (1-0) against the Athletics and Jeffrey Springs (10-11). Early helped his team cover the spread in his only opportunity this season as a starter. Early has yet to start a game this season when his team was the moneyline favorite. The Athletics have gone 14-14-0 against the spread when Springs starts. The Athletics are 11-7 in Springs' 18 starts this season that they were the moneyline underdog.

Red Sox vs Athletics Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Red Sox win (53.9%)

Red Sox vs Athletics Moneyline

• The Red Sox vs Athletics moneyline has the Red Sox as a -162 favorite, while the Athletics are a +136 underdog on the road.

Red Sox vs Athletics Spread

• The Red Sox are 1.5-run favorites on the runline against the Athletics. The Red Sox are +126 to cover, while the Athletics are -152 to cover.

Red Sox vs Athletics Over/Under

• A combined run total of 8.5 has been set for Red Sox-Athletics on Sept. 16, with the over at -114 and the under at -106.

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Red Sox vs Athletics Betting Trends

• The Red Sox have been favorites in 93 games this season and have come away with the win 54 times (58.1%) in those contests.
• This year, the Red Sox have won 19 of 30 games when listed as at least -162 or better on the moneyline.
• The Red Sox and their opponents have hit the over in 70 of their 149 games with a total this season.
• The Red Sox are 80-69-0 against the spread in their 149 games with a line set by sportsbooks this season.
• The Athletics have a 51-60 record in games they were the underdog on the moneyline (winning 45.9% of those games).
• The Athletics have a record of 12-25 in games they have played as a moneyline underdog with odds of +136 or longer (32.4%).
• The Athletics have played in 149 games with a set over/under, and have combined with their opponents to go over the total 74 times (74-69-6).
• The Athletics have a 79-70-0 record ATS this season (covering 53% of the time).

Red Sox Player Leaders

• Jarren Duran leads Boston with 148 hits and an OBP of .333, plus a team-best slugging percentage of .449. He's batting .258.
• Among the qualified hitters in the majors, his batting average ranks 73rd, his on-base percentage ranks 62nd, and he is 59th in slugging.
• Duran will look for his third straight game with a hit in this contest. During his last five outings he is batting .235 with two doubles, a triple, a home run and two RBIs.
• Trevor Story is hitting .261 with 27 doubles, 24 home runs and 31 walks, while slugging .437 with an on-base percentage of .307.
• Among qualified hitters, his batting average places him 64th, his on-base percentage 115th, and his slugging percentage 70th.
• Alex Bregman is batting .278 with a .475 slugging percentage and 59 RBI this year.
• Bregman heads into this matchup with six games in a row with at least one hit. In his last 10 outings he is hitting .220 with two doubles, a home run, four walks and five RBIs.
• Ceddanne Rafaela has 16 home runs, 60 RBI and a batting average of .239 this season.

Athletics Player Leaders

• Brent Rooker has put up a team-high .495 slugging percentage. He's batting .269 with an on-base percentage of .339.
• Including all qualifying hitters, he ranks 40th in batting average, while his on-base percentage ranks 52nd and he is 21st in slugging.
• Rooker takes a four-game hitting streak into this game. During his last five outings he is hitting .333 with two doubles, two home runs, two walks and three RBIs.
• Tyler Soderstrom is hitting .275 with 30 doubles, a triple, 24 home runs and 52 walks. He's slugging .474 with an on-base percentage of .346.
• He is currently 32nd in batting average, 42nd in on-base percentage and 35th in slugging percentage among all qualifying hitters.
• Nick Kurtz has 24 doubles, two triples, 32 home runs and 59 walks while hitting .298.
• Shea Langeliers has 117 hits to lead his team.

Red Sox vs Athletics Head to Head

• 9/10/2025: 5-4 OAK (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 9/9/2025: 6-0 BOS (Favorite: Athletics, Spread: -1.5, Total: 10.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 9/8/2025: 7-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/11/2024: 7-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 9.5, Favorite Moneyline: -230, Underdog Moneyline: +190)
• 7/10/2024: 5-2 OAK (Favorite: Red Sox, Spread: -1.5, Total: 10, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 7/9/2024: 12-9 BOS (Favorite: Red Sox, Spread: -1.5, Total: 10.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 4/3/2024: 1-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 4/2/2024: 5-4 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 4/1/2024: 9-0 BOS (Favorite: Red Sox, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 7/19/2023: 6-5 OAK (Favorite: Red Sox, Spread: -1.5, Total: 8.5, Favorite Moneyline: -230, Underdog Moneyline: +190)

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