Rays vs Guardians Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 5

Odds updated as of 7:13 p.m.

The Friday schedule in MLB includes a matchup between the Tampa Bay Rays and the Cleveland Guardians.

Before you do any MLB betting on this game at FanDuel Sportsbook, here's what you need to know.

Rays vs Guardians Game Info

• Tampa Bay Rays (71-69) vs. Cleveland Guardians (69-70)
• Date: Friday, September 5, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and CLEG

Rays vs Guardians Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-148) | CLE: (+126)
• Spread: TB: -1.5 (+146) | CLE: +1.5 (-176)
• Total: 7.5 -- Over: (-100) | Under: (-122)

Rays vs Guardians Probable Starting Pitchers

Probable Pitchers: Griffin Jax (Rays) - 1-7, 4.98 ERA vs Gavin Williams (Guardians) - 9-5, 3.26 ERA

The probable starters are Griffin Jax (1-7) for the Rays and Gavin Williams (9-5) for the Guardians. Jax did not pitch in a game with a spread last season. Jax did not pitch as the moneyline favorite last season. The Guardians have a 12-15-0 record against the spread in Williams' starts. The Guardians are 7-10 in Williams' 17 starts this season that they were the moneyline underdog.

Rays vs Guardians Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (67%)

Rays vs Guardians Moneyline

• The moneyline numbers for Rays vs. Guardians reveal Tampa Bay as the favorite (-148) and Cleveland as the underdog (+126) on the road.

Rays vs Guardians Spread

• The Rays are favored by 1.5 runs at home versus the Guardians. The Rays are +146 to cover the spread, while the Guardians are -176.

Rays vs Guardians Over/Under

• An over/under of 7.5 has been set for Rays-Guardians on Sept. 5, with the over being -100 and the under -122.

Bet on Tampa Bay Rays vs. Cleveland Guardians on FanDuel today!

Rays vs Guardians Betting Trends

• The Rays have been favorites in 63 games this season and have come away with the win 38 times (60.3%) in those contests.
• This season Tampa Bay has come away with a win eight times in 20 chances when named as a favorite of at least -148 on the moneyline.
• Contests with the Rays have gone over the total set by oddsmakers in 58 of 135 chances this season.
• In 135 games with a line this season, the Rays have a mark of 61-74-0 against the spread.
• The Guardians have compiled a 33-46 record in games they were listed as the moneyline underdog (winning 41.8% of those games).
• Cleveland has gone 15-16 when playing as a moneyline underdog with odds of +126 or longer (48.4%).
• The Guardians have had an over/under set by bookmakers 136 times, and have combined with opponents to go over the total in 61 of those games (61-69-6).
• The Guardians have collected a 70-66-0 record against the spread this season (covering 51.5% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 139 hits, batting .263 this season with 65 extra-base hits. He has an on-base percentage of .304 and a slugging percentage of .538.
• Among qualified batters, he is 65th in batting average, his on-base percentage ranks 126th, and he is ninth in slugging.
• Caminero hopes to build on a four-game hitting streak in this matchup. During his last five outings he is batting .429 with three doubles, a home run and eight RBIs.
• Yandy Diaz leads the Rays with an OPS of .826. He has a slash line of .292/.351/.475 this season.
• His batting average ranks 13th among qualified players, his on-base percentage 42nd, and his slugging percentage 38th.
• Brandon Lowe has 116 hits this season and has a slash line of .265/.318/.491.
• Lowe brings an eight-game hitting streak into this matchup. In his last 10 outings he is hitting .250 with two doubles, three home runs, four walks and 11 RBIs.
• Chandler Simpson has been key for Tampa Bay with 99 hits, an OBP of .324 plus a slugging percentage of .340.

Guardians Player Leaders

• Jose Ramirez has an on-base percentage of .354 and has 142 hits, both team-high numbers for the Guardians. He's batting .280 and slugging .497.
• He ranks 24th in batting average, 34th in on-base percentage and 21st in slugging percentage among all qualified hitters in the majors.
• Steven Kwan is slugging .379 to lead his team. He has a batting average of .272 with an on-base percentage of .328.
• Including all qualified players, he is 39th in batting average, 82nd in on-base percentage and 130th in slugging percentage.
• Kyle Manzardo has 14 doubles, two triples, 25 home runs and 43 walks while hitting .232.
• Angel Martinez has 21 doubles, a triple, 10 home runs and 17 walks while batting .225.

Rays vs Guardians Head to Head

• 9/4/2025: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 8/27/2025: 4-3 CLE (Favorite: Rays, Spread: -1.5, Total: 7, Favorite Moneyline: -148, Underdog Moneyline: +126)
• 8/26/2025: 3-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/25/2025: 9-0 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 9/15/2024: 2-0 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 9/14/2024: 6-1 CLE (Favorite: Guardians, Spread: -1.5, Total: 8, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 9/13/2024: 3-1 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 9/12/2024: 5-2 TB (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 7/14/2024: 2-0 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/13/2024: 4-2 CLE (Favorite: Guardians, Spread: -1.5, Total: 7.5, Favorite Moneyline: -110, Underdog Moneyline: -106)

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