Rays vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 22

Odds updated as of 7:12 p.m.

The Tampa Bay Rays will face the St. Louis Cardinals in MLB action on Friday.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Rays vs Cardinals Game Info

• Tampa Bay Rays (61-67) vs. St. Louis Cardinals (64-65)
• Date: Friday, August 22, 2025
• Time: 7:35 p.m. ET
• Venue: George M. Steinbrenner Field -- Tampa, Florida
• Coverage: FDSSUN and FDSMW

Rays vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: TB: (-138) | STL: (+118)
• Spread: TB: -1.5 (+152) | STL: +1.5 (-184)
• Total: 8.5 -- Over: (-124) | Under: (+102)

Rays vs Cardinals Probable Starting Pitchers

Probable Pitchers: Adrian Houser (Rays) - 6-4, 2.67 ERA vs Miles Mikolas (Cardinals) - 6-9, 4.99 ERA

The Rays will give the ball to Adrian Houser (6-4, 2.67 ERA), who is eyeing win No. 7 on the season, and the Cardinals will counter with Miles Mikolas (6-9, 4.99 ERA). Houser and his team are 8-5-0 ATS this season when he starts. Houser's team is 2-0 this season when he starts and they're favored on the moneyline. When Mikolas starts, the Cardinals have gone 10-14-0 against the spread. The Cardinals have a 7-10 record in Mikolas' 17 starts this season when they were the moneyline underdog.

Rays vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Rays win (59.9%)

Rays vs Cardinals Moneyline

• The moneyline numbers for Rays vs. Cardinals reveal Tampa Bay as the favorite (-138) and St. Louis as the underdog (+118) on the road.

Rays vs Cardinals Spread

• The Rays are hosting the Cardinals and are favored by 1.5 runs (+152 to cover) on the runline. St. Louis is -184 to cover.

Rays vs Cardinals Over/Under

• The over/under for Rays-Cardinals on Aug. 22 is 8.5. The over is -124, and the under is +102.

Bet on Tampa Bay Rays vs. St. Louis Cardinals on FanDuel today!

Rays vs Cardinals Betting Trends

• The Rays have been favorites in 57 games this season and have come away with the win 33 times (57.9%) in those contests.
• This year Tampa Bay has won 14 of 27 games when listed as at least -138 on the moneyline.
• The Rays and their opponents have gone over the total this season in 52 of their 124 opportunities.
• The Rays have an against the spread mark of 52-72-0 in 124 games with a line this season.
• The Cardinals are 33-35 in games they were listed as the moneyline underdog (winning 48.5% of those games).
• St. Louis has a record of 14-20 when it has played as a moneyline underdog with odds of +118 or longer (41.2%).
• The Cardinals have had an over/under set by bookmakers 124 times, and have combined with opponents to go over the total in 64 of those games (64-55-5).
• The Cardinals have a 64-60-0 record ATS this season (covering 51.6% of the time).

Rays Player Leaders

• Junior Caminero leads Tampa Bay with 122 hits, batting .255 this season with 56 extra-base hits. He has an on-base percentage of .298 and a slugging percentage of .519.
• Among qualifying hitters in the majors, his batting average ranks 88th, his on-base percentage ranks 136th, and he is 13th in slugging.
• Caminero hopes to build on a two-game hitting streak in this matchup. In his last five games he is hitting .105 with three walks and an RBI.
• Yandy Diaz leads Tampa Bay in slugging percentage (.463) thanks to 44 extra-base hits. He's batting .281 with an on-base percentage of .341.
• He is 28th in batting average, 52nd in on-base percentage and 53rd in slugging in the major leagues.
• Brandon Lowe is batting .269 with a .485 slugging percentage and 62 RBI this year.
• Chandler Simpson has been key for Tampa Bay with 87 hits, an OBP of .339 plus a slugging percentage of .354.
• Simpson has safely hit in three games in a row. During his last five outings he is batting .238 with a double, two walks and an RBI.

Cardinals Player Leaders

• Alec Burleson is hitting .285 with 20 doubles, a triple, 15 home runs and 33 walks. He's slugging .449 with an on-base percentage of .337.
• Including all the qualifying hitters in the majors, his batting average is 23rd, his on-base percentage ranks 60th, and he is 65th in slugging.
• Willson Contreras' 112 hits pace his team. He has a batting average of .261 while slugging .455 with an on-base percentage of .345.
• Including all qualified players, his batting average puts him 70th, his on-base percentage is 49th, and he is 60th in slugging.
• Masyn Winn is batting .260 with 26 doubles, nine home runs and 31 walks.
• Lars Nootbaar has 20 doubles, 13 home runs and 50 walks while hitting .244.

Rays vs Cardinals Head to Head

• 8/21/2025: 7-4 STL (Favorite: Cardinals, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/8/2024: 6-4 TB (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/7/2024: 5-2 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 8/6/2024: 4-3 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/10/2023: 5-2 STL (Favorite: Rays, Spread: -1.5, Total: 9.5, Favorite Moneyline: -210, Underdog Moneyline: +176)
• 8/9/2023: 6-4 STL (Favorite: Rays, Spread: -1.5, Total: 9, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/8/2023: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 8.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 6/9/2022: 2-1 TB (Favorite: Rays, Spread: -1.5, Total: 6.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 6/8/2022: 11-3 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/7/2022: 4-2 TB (Favorite: Rays, Spread: -1.5, Total: 7.5, Favorite Moneyline: -146, Underdog Moneyline: +124)

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