Pistons vs. Cavaliers Eastern Semifinals Prediction, Odds, Picks, Best Bets for May 7

Pistons vs. Cavaliers Game Info

• Date: Thursday, May 7, 2026
• Time: 7 p.m. ET
• Venue: Little Caesars Arena -- Detroit, Michigan
• Coverage: Amazon Prime Video

The Detroit Pistons are slight 3.5-point favorites heading into Game 2 of the second round of the NBA Playoffs against the Cleveland Cavaliers at Little Caesars Arena on Thursday, tipping off at 7 p.m. ET on Amazon Prime Video. The Pistons hold a 1-0 series lead. The matchup has an over/under of 215.5.

Pistons vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Pistons vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (68.1%)

Pistons vs. Cavaliers Betting Trends

• The Pistons are 44-35-2 against the spread this season.
• The Cavaliers are 33-47-2 against the spread this year.
• Pistons games have finished with a final combined score above the over/under 40 times this season.
• Cavaliers games this year have hit the over 41 times in 82 opportunities (50%).
• Detroit has done a better job covering the spread on the road (23-16-1) than it has in home games (21-19-1).
• The Pistons have hit the over on the over/under in the same percentage of home games as road tilts (48.8%).
• In 2025-26 against the spread, Cleveland has a better winning percentage at home (.415, 17-23-1 record) than on the road (.390, 16-24-1).
• Looking at the over/under, Cavaliers games have finished over 17 of 41 times at home (41.5%), and 24 of 41 on the road (58.5%).

Pistons Leaders

• Cade Cunningham averages 23.9 points, 5.5 boards and 9.9 assists, shooting 46.1% from the floor and 34.2% from beyond the arc, with 2 made treys per game.
• Jalen Duren is averaging 19.5 points, 10.5 rebounds and 2 assists. At the other end, he averages 0.8 steals and 0.8 blocked shots.
• Ausar Thompson averages 9.9 points, 5.7 rebounds and 3.1 assists, shooting 52.5% from the field.
• Tobias Harris is averaging 13.3 points, 5.1 boards and 2.5 assists.
• Duncan Robinson's numbers on the season are 12.2 points, 2.7 boards and 2.1 assists per contest, shooting 45.6% from the floor and 41% from downtown, with an average of 2.9 made treys.

Cavaliers Leaders

• Donovan Mitchell is averaging 27.9 points, 4.5 boards and 5.7 assists for the Cavaliers.
• The Cavaliers are receiving 23.6 points, 4.8 boards and 8 assists per game from James Harden.
• Evan Mobley averages 18.2 points, 9 boards and 3.6 assists. He is draining 54.6% of his shots from the field and 29.7% from beyond the arc, with 1 triples per contest.
• Jarrett Allen's numbers on the season are 15.4 points, 8.5 rebounds and 1.8 assists per game. He is making 63.8% of his shots from the field (fifth in NBA).
• Jaylon Tyson averages 13.2 points, 5.1 rebounds and 2.2 assists. He is draining 49.3% of his shots from the floor and 44.6% from beyond the arc (fourth in NBA), with 2 treys per game.

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