Pistons vs. Cavaliers Eastern Semifinals Prediction, Odds, Picks, Best Bets for May 5

Pistons vs. Cavaliers Game Info

• Date: Tuesday, May 5, 2026
• Time: 7 p.m. ET
• Venue: Little Caesars Arena -- Detroit, Michigan
• Coverage: Peacock and NBC Sports

The Detroit Pistons and the Cleveland Cavaliers meet to begin the second round of the NBA Playoffs. The Pistons are favored by 3.5 points in the matchup, which airs on Peacock and NBC Sports at 7 p.m. ET. The matchup's over/under is 215.5.

Pistons vs. Cavaliers Odds & Spread

All NBA betting lines, odds and prop bets are from FanDuel Sportsbook.

Pistons vs. Cavaliers Prediction & Pick

All NBA win probability predictions and picks are according to numberFire.
Prediction: Pistons win (68.1%)

Pistons vs. Cavaliers Betting Trends

• The Pistons have gone 44-35-2 against the spread this season.
• The Cavaliers have played 82 games, with 33 wins against the spread.
• Games involving the Pistons have hit the over 40 times this season.
• Cavaliers games this year have hit the over 41 times in 82 opportunities (50%).
• Against the spread, Detroit has performed worse at home, covering 21 times in 41 home games, and 23 times in 41 road games.
• In home games, the Pistons exceed the total 48.8% of the time (20 of 41 games). They hit the over in the same percentage of away games (20 of 41 contests).
• In 2025-26 against the spread, Cleveland has a better winning percentage at home (.415, 17-23-1 record) than away (.390, 16-24-1).
• Looking at the over/under, Cavaliers games have finished over less frequently at home (17 of 41, 41.5%) than on the road (24 of 41, 58.5%).

Pistons Leaders

• Cade Cunningham averages 23.9 points, 5.5 rebounds and 9.9 assists, shooting 46.1% from the floor and 34.2% from beyond the arc, with 2 made treys per game.
• Jalen Duren averages 19.5 points, 10.5 boards and 2 assists, shooting 65% from the floor (fourth in NBA).
• Ausar Thompson is averaging 9.9 points, 5.7 boards and 3.1 assists. Defensively, he averages 2 steals (first in league) and 0.9 blocked shots.
• Tobias Harris is averaging 13.3 points, 5.1 rebounds and 2.5 assists. At the other end, he averages 0.9 steals and 0.4 blocked shots.
• Duncan Robinson is averaging 12.2 points, 2.1 assists and 2.7 boards.

Cavaliers Leaders

• Donovan Mitchell is averaging 27.9 points, 4.5 rebounds and 5.7 assists for the Cavaliers.
• James Harden averages 23.6 points, 4.8 rebounds and 8 assists. He is also sinking 43.4% of his shots from the field and 37.5% from beyond the arc, with 3.1 treys per game (ninth in league).
• Evan Mobley averages 18.2 points, 9 boards and 3.6 assists. He is draining 54.6% of his shots from the floor and 29.7% from 3-point range, with 1 treys per game.
• Jarrett Allen averages 15.4 points, 8.5 boards and 1.8 assists. He is making 63.8% of his shots from the field (fifth in NBA).
• Jaylon Tyson's numbers on the season are 13.2 points, 5.1 rebounds and 2.2 assists per game. He is making 49.3% of his shots from the field and 44.6% from 3-point range (fourth in league), with an average of 2 treys.

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