Padres vs Giants Prediction, Odds, Moneyline, Spread & Over/Under for May 4

Odds updated as of 5:13 a.m.

On Monday in MLB, the San Diego Padres are up against the San Francisco Giants.

We've got you covered, in terms of the most important information regarding this game before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Giants Game Info

• San Diego Padres (20-13) vs. San Francisco Giants (13-21)
• Date: Monday, May 4, 2026
• Time: 9:45 p.m. ET
• Venue: Oracle Park -- San Francisco, California
• Coverage: NBCS-BA and Padres.TV

Padres vs Giants Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-142) | SF: (+120)
• Spread: SD: -1.5 (+118) | SF: +1.5 (-142)
• Total: 8 -- Over: (-110) | Under: (-110)

Padres vs Giants Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 3-0, 2.94 ERA vs Trevor McDonald (Giants) - 0-0, 0.00 ERA

This contest's pitching matchup is set, as the Padres will send Randy Vasquez (3-0) to the mound, while Trevor McDonald will answer the bell for the Giants. When Vasquez starts, his team is 5-1-0 against the spread this season. Vasquez's team has won each of the three games he's started as the moneyline favorite. McDonald did not pitch as a moneyline underdog a season ago.

Padres vs Giants Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (54.7%)

Padres vs Giants Moneyline

• Looking at the moneyline for Padres-Giants, San Diego is the favorite at -142, and San Francisco is +120 playing at home.

Padres vs Giants Spread

• The Padres are 1.5-run road favorites on the runline against the Giants. The Padres are +118 to cover, and the Giants are -142.

Padres vs Giants Over/Under

• The over/under for Padres-Giants on May 4 is 8. The over is -110, and the under is -110.

Bet on San Diego Padres vs. San Francisco Giants on FanDuel today!

Padres vs Giants Betting Trends

• The Padres have been favorites in 18 games this season and have come away with the win 11 times (61.1%) in those contests.
• This season San Diego has come away with a win nine times in 12 chances when named as a favorite of at least -142 on the moneyline.
• Contests with the Padres have gone over the total set by oddsmakers in 15 of 33 chances this season.
• The Padres are 19-14-0 against the spread in their 33 games that had a posted line this season.
• The Giants are 8-15 in games they were the underdog on the moneyline (winning 34.8% of those games).
• In games it has played as a moneyline underdog with odds of +120 or longer, San Francisco has gone 3-4 (42.9%).
• In the 34 games bookmakers have set an over/under for the Giants, they have combined with opponents to go over the total 14 times (14-17-3).
• The Giants have gone 14-20-0 ATS this season.

Padres Player Leaders

• Xander Bogaerts leads San Diego in OBP (.351), slugging percentage (.412) and total hits (32) this season. He has a .269 batting average.
• Among all qualifying batters in baseball, he is 54th in batting average, 65th in on-base percentage, and 84th in slugging.
• Manny Machado is hitting .229 with four doubles, five home runs and 19 walks, while slugging .404 with an on-base percentage of .338.
• Among qualifying hitters, his batting average ranks him 121st, his on-base percentage 78th, and his slugging percentage 94th.
• Jackson Merrill has collected 26 base hits, an OBP of .276 and a slugging percentage of .333 this season.
• Merrill has logged a hit or more in two games in a row. During his last five outings he is batting .200 with a walk and an RBI.
• Ramon Laureano is batting .237 with a .303 OBP and 18 RBI for San Diego this season.

Giants Player Leaders

• Luis Arraez has a team-best .377 slugging percentage. He's batting .308 with an on-base percentage of .333.
• He is 21st in batting average, 86th in on-base percentage and 112th in slugging percentage among all qualifying hitters in the big leagues.
• Jung Hoo Lee is batting .281 with eight doubles, a triple, two home runs and 10 walks. He's slugging .413 with an on-base percentage of .331.
• He is currently 40th in batting average, 92nd in on-base percentage and 83rd in slugging percentage among all qualified hitters.
• Casey Schmitt has accumulated 32 hits with a .354 on-base percentage, leading the Giants in both categories.
• Matt Chapman has six doubles, a triple, a home run and 14 walks while batting .246.

Padres vs Giants Head to Head

• 4/1/2026: 7-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 3/31/2026: 9-3 SF (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 3/30/2026: 3-2 SF (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 8/21/2025: 8-4 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/20/2025: 8-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 8/19/2025: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -215, Underdog Moneyline: +180)
• 8/18/2025: 4-3 SF (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/13/2025: 11-1 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 8/12/2025: 5-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/11/2025: 4-1 SD (Favorite: Giants, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)

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