Pirates vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 4

Odds updated as of 1:11 p.m.

The MLB schedule on Sunday includes the Pittsburgh Pirates facing the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Padres Game Info

• Pittsburgh Pirates (12-22) vs. San Diego Padres (21-11)
• Date: Sunday, May 4, 2025
• Time: 1:35 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and SDPA

Pirates vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-108) | SD: (-108)
• Spread: PIT: +1.5 (-184) | SD: -1.5 (+152)
• Total: 9 -- Over: (-100) | Under: (-122)

Pirates vs Padres Probable Starting Pitchers

Probable Pitchers: Andrew Heaney (Pirates) - 2-2, 2.50 ERA vs Stephen Kolek (Padres) - 0-0, 0.00 ERA

The probable starters are Andrew Heaney (2-2) for the Pirates and Stephen Kolek for the Padres. Heaney and his team are 2-4-0 ATS this season when he starts. Heaney's team won his only start as a favorite this season. Kolek's team was never a moneyline underdog a season ago in games he pitched.

Pirates vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (57.4%)

Pirates vs Padres Moneyline

• San Diego is the underdog, -108 on the moneyline, while Pittsburgh is a -108 favorite at home.

Pirates vs Padres Spread

Pirates vs Padres Over/Under

• The over/under for the Pirates versus Padres game on May 4 has been set at 9, with -100 odds on the over and -122 odds on the under.

Bet on Pittsburgh Pirates vs. San Diego Padres on FanDuel today!

Pirates vs Padres Betting Trends

• The Pirates have been victorious in five, or 41.7%, of the 12 contests they have been chosen as favorites in this season.
• This season Pittsburgh has been victorious five times in 12 chances when named as a favorite of at least -108 on the moneyline.
• Contests with the Pirates have gone over the total set by oddsmakers in 16 of 33 chances this season.
• The Pirates are 12-21-0 against the spread in their 33 games that had a posted line this season.
• The Padres have put together a 7-7 record in games they were the underdog on the moneyline (winning 50% of those games).
• San Diego has gone 7-7 when it has played as a moneyline underdog with odds of -108 or longer (50%).
• In the 31 games bookmakers have set an over/under for the Padres, they have combined with opponents to go over the total 13 times (13-17-1).
• The Padres have put together an 18-13-0 record against the spread this season (covering 58.1% of the time).

Pirates Player Leaders

• Oneil Cruz leads Pittsburgh in OBP (.388) and total hits (27) this season. He's batting .252 batting average while slugging .523.
• Among qualified batters in baseball, his batting average ranks 77th, his on-base percentage ranks 17th, and he is 19th in slugging.
• Andrew McCutchen is batting .266 with six doubles, three home runs and 13 walks, while slugging .426 with an on-base percentage of .361.
• Among qualifying hitters, his batting average ranks him 62nd, his on-base percentage 41st, and his slugging percentage 70th.
• McCutchen has picked up a hit in two straight games. During his last five outings he is hitting .222 with two doubles, two walks and two RBI.
• Bryan Reynolds has hit four homers with a team-high .363 SLG this season.
• Enmanuel Valdez is batting .218 with a .315 OBP and 12 RBI for Pittsburgh this season.

Padres Player Leaders

• Fernando Tatis Jr. has an on-base percentage of .414, a slugging percentage of .598, and has 40 hits, all club-bests for the Padres (while batting .342).
• He ranks fourth in batting average, sixth in on-base percentage and fourth in slugging percentage among all qualifying batters in the big leagues.
• Manny Machado is batting .280 with 10 doubles, three home runs and 12 walks. He's slugging .441 with an on-base percentage of .344.
• He is 38th in batting average, 59th in on-base percentage and 61st in slugging percentage in the majors.
• Luis Arraez is batting .301 with four doubles, a triple, three home runs and five walks.
• Xander Bogaerts is hitting .234 with eight doubles, a home run and 14 walks.

Pirates vs Padres Head to Head

• 5/2/2025: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 8/14/2024: 8-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 8/13/2024: 3-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 8/12/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/8/2024: 7-6 SD (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -110, Underdog Moneyline: -106)
• 8/7/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -158, Underdog Moneyline: +134)
• 8/6/2024: 6-0 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -164, Underdog Moneyline: +138)
• 7/26/2023: 3-2 PIT (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -188, Underdog Moneyline: +158)
• 7/25/2023: 5-1 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -290, Underdog Moneyline: +235)
• 7/24/2023: 8-4 PIT (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -275, Underdog Moneyline: +225)

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