Padres vs Cardinals Prediction, Odds, Moneyline, Spread & Over/Under for Aug. 2

Odds updated as of 10:15 p.m.

The MLB schedule on Saturday includes the San Diego Padres taking on the St. Louis Cardinals.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Padres vs Cardinals Game Info

• San Diego Padres (61-49) vs. St. Louis Cardinals (55-56)
• Date: Saturday, August 2, 2025
• Time: 10:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSMW

Padres vs Cardinals Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-188) | STL: (+158)
• Spread: SD: -1.5 (+105) | STL: +1.5 (-126)
• Total: 8 -- Over: (-115) | Under: (-105)

Padres vs Cardinals Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 3-4, 3.65 ERA vs Michael McGreevy (Cardinals) - 2-2, 4.91 ERA

This contest's pitching matchup is set, as the Padres will send Randy Vasquez (3-4) to the mound, while Michael McGreevy (2-2) will take the ball for the Cardinals. Vasquez's team is 13-7-0 against the spread in his starts this season. Vasquez's team has won each of the five games he's started as the moneyline favorite. The Cardinals have a 3-2-0 ATS record in McGreevy's five starts that had a set spread. The Cardinals were the underdog on the moneyline for two McGreevy starts this season -- they split the games.

Padres vs Cardinals Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (58.6%)

Padres vs Cardinals Moneyline

• The moneyline numbers for Padres vs. Cardinals reveal San Diego as the favorite (-188) and St. Louis as the underdog (+158) on the road.

Padres vs Cardinals Spread

• The Cardinals are at the Padres, and are +1.5 on the runline. The Cardinals are +105 to cover the spread, and the Padres are -126.

Padres vs Cardinals Over/Under

• The over/under for Padres-Cardinals on Aug. 2 is 8. The over is -115, and the under is -105.

Bet on San Diego Padres vs. St. Louis Cardinals on FanDuel today!

Padres vs Cardinals Betting Trends

• The Padres have won in 33, or 61.1%, of the 54 contests they have been named as odds-on favorites in this year.
• San Diego has a record of 6-4 in contests when bookmakers favor them by -188 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 44 of their 108 opportunities.
• In 108 games with a line this season, the Padres have a mark of 60-48-0 against the spread.
• The Cardinals have been the moneyline underdog 55 total times this season. They've finished 27-28 in those games.
• When playing as a moneyline underdog with odds of +158 or longer, St. Louis has a 1-4 record (winning just 20% of its games).
• The Cardinals have combined with opponents to go over the total 54 times this season for a 54-49-5 record against the over/under.
• The Cardinals have gone 56-52-0 against the spread this season.

Padres Player Leaders

• Manny Machado leads San Diego with 128 hits and a team-best slugging percentage of .507. He's batting .302 with an on-base percentage of .361.
• Among all qualifying hitters in baseball, he ranks eighth in batting average, 29th in on-base percentage, and 16th in slugging.
• Machado hopes to build on a nine-game hitting streak in this matchup. During his last 10 outings he is hitting .452 with four doubles, two home runs and 11 RBIs.
• Fernando Tatis Jr. is hitting .267 with 18 doubles, two triples, 17 home runs and 61 walks. He's slugging .446 with an on-base percentage of .368.
• Among qualifying batters, he ranks 62nd in batting average, 22nd in on-base percentage and 68th in slugging percentage.
• Luis Arraez is batting .297 with a .406 slugging percentage and 41 RBI this year.
• Arraez has recorded at least one base hit in 14 straight games. During his last 10 outings he is batting .425 with three doubles, a home run, three walks and five RBIs.
• Xander Bogaerts has been key for San Diego with 104 hits, an OBP of .339 plus a slugging percentage of .382.
• Bogaerts takes a two-game hitting streak into this matchup. During his last five outings he is batting .273 with a double, a home run, a walk and two RBIs.

Cardinals Player Leaders

• Brendan Donovan has accumulated an on-base percentage of .354 and a slugging percentage of .412. Both lead the Cardinals. He's batting .282.
• Including all qualified hitters, he is 28th in batting average, while his on-base percentage is 39th and he is 94th in slugging.
• Alec Burleson has collected 96 hits to pace his team. He has a batting average of .284 while slugging .464 with an on-base percentage of .338.
• He is currently 26th in batting average, 63rd in on-base percentage and 49th in slugging percentage among all qualifying hitters.
• Willson Contreras is hitting .257 with 28 doubles, 15 home runs and 34 walks.
• Masyn Winn is batting .271 with 23 doubles, seven home runs and 27 walks.

Padres vs Cardinals Head to Head

• 8/1/2025: 4-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 7/27/2025: 9-2 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 7/26/2025: 3-1 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 7/25/2025: 3-0 STL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/24/2025: 9-7 STL (Favorite: Cardinals, Spread: -1.5, Total: 8, Favorite Moneyline: -154, Underdog Moneyline: +130)
• 8/29/2024: 4-1 STL (Favorite: Cardinals, Spread: -1.5, Total: 7.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 8/28/2024: 4-3 STL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/27/2024: 7-5 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 8/26/2024: 7-4 SD (Favorite: Cardinals, Spread: -1.5, Total: 9, Favorite Moneyline: -120, Underdog Moneyline: +102)
• 4/3/2024: 3-2 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -158, Underdog Moneyline: +134)

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