Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 16

Odds updated as of 6:14 p.m.

The Tuesday schedule in MLB includes a matchup between the Pittsburgh Pirates and the Chicago Cubs.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (65-86) vs. Chicago Cubs (86-64)
• Date: Tuesday, September 16, 2025
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-132) | CHC: (+112)
• Spread: PIT: -1.5 (+172) | CHC: +1.5 (-210)
• Total: 6.5 -- Over: (-118) | Under: (-104)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 10-9, 1.92 ERA vs Cade Horton (Cubs) - 10-4, 2.70 ERA

The Pirates will give the nod to Paul Skenes (10-9) against the Cubs and Cade Horton (10-4). Skenes' team is 15-15-0 against the spread in his starts this season. Skenes' team is 11-8 this season when he starts and they are the moneyline favorite. The Cubs have a 10-10-0 ATS record in Horton's 20 starts that had a set spread. The Cubs have a 1-4 record in Horton's five starts this season when they were the underdog on the moneyline.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (53.5%)

Pirates vs Cubs Moneyline

• Looking at the moneyline for Pirates-Cubs, Pittsburgh is the favorite at -132, and Chicago is +112 playing on the road.

Pirates vs Cubs Spread

• The Pirates are hosting the Cubs and are favored by 1.5 runs (+172 to cover) on the runline. Chicago is -210 to cover.

Pirates vs Cubs Over/Under

• A total of 6.5 runs has been set for the Pirates-Cubs contest on Sept. 16, with the over available at -118 and the under at -104.

Bet on Pittsburgh Pirates vs. Chicago Cubs on FanDuel today!

Pirates vs Cubs Betting Trends

• The Pirates have been chosen as favorites in 39 games this year and have walked away with the win 20 times (51.3%) in those games.
• Pittsburgh has a record of 11-11 when favored by -132 or more this year.
• Contests with the Pirates have gone over the total set by oddsmakers in 55 of 143 chances this season.
• The Pirates have an against the spread record of 77-66-0 in 143 games with a line this season.
• The Cubs have won 17 of the 40 games they were the moneyline underdog this season (42.5%).
• When playing as a moneyline underdog with odds of +112 or longer, Chicago has gone 5-9 (35.7%).
• The Cubs have had an over/under set by bookmakers 146 times, and have combined with opponents to go over the total in 67 of those games (67-69-10).
• The Cubs have put together a 68-78-0 record against the spread this season (covering 46.6% of the time).

Pirates Player Leaders

• Bryan Reynolds leads Pittsburgh with 134 hits and a team-best slugging percentage of .399. He's batting .243 with an on-base percentage of .313.
• He ranks 103rd in batting average, 106th in on-base percentage, and 102nd in slugging among all qualified batters in the majors.
• Andrew McCutchen leads Pittsburgh with an OBP of .334 this season while batting .239 with 63 walks and 48 runs scored. He's slugging .376.
• He is 113th in batting average, 59th in on-base percentage and 126th in slugging among qualifying batters.
• Oneil Cruz has collected 90 base hits, an OBP of .305 and a slugging percentage of .382 this season.
• Spencer Horwitz is batting .260 with a .336 OBP and 42 RBI for Pittsburgh this season.
• Horwitz heads into this matchup on a two-game hitting streak. During his last five outings he is hitting .333 with a double, a home run, three walks and two RBIs.

Cubs Player Leaders

• Nico Hoerner has accumulated a team-best .399 slugging percentage. He's batting .299 with an on-base percentage of .348.
• Including all the qualifying players in the majors, his batting average places him seventh, his on-base percentage is 40th, and he is 102nd in slugging.
• Hoerner enters this game on a 10-game hitting streak. During his last 10 outings he is batting .436 with five doubles, a triple, a home run, five walks and five RBIs.
• Pete Crow-Armstrong paces his team with 136 hits. He has a batting average of .248 while slugging .486 with an on-base percentage of .290.
• His batting average is 93rd among all qualified players, his on-base percentage ranks 135th, and he is 26th in slugging.
• Ian Happ is batting .242 with 28 doubles, 22 home runs and 82 walks.
• Seiya Suzuki has 29 doubles, three triples, 27 home runs and 67 walks while batting .244.

Pirates vs Cubs Head to Head

• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/15/2025: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 6/15/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -146, Underdog Moneyline: +124)
• 6/14/2025: 2-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -235, Underdog Moneyline: +194)
• 6/13/2025: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/12/2025: 3-2 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -205, Underdog Moneyline: +172)
• 5/1/2025: 8-3 CHC (Favorite: Pirates, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 4/30/2025: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)

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