Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for May 28

Odds updated as of 6:12 p.m.

The Pittsburgh Pirates are among the MLB teams busy on Thursday, up against the Chicago Cubs.

Before you do any MLB betting on this matchup at FanDuel Sportsbook, here's what you need to know.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (29-27) vs. Chicago Cubs (30-26)
• Date: Thursday, May 28, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-174) | CHC: (+146)
• Spread: PIT: -1.5 (+122) | CHC: +1.5 (-146)
• Total: 7.5 -- Over: (-112) | Under: (-108)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Paul Skenes (Pirates) - 6-4, 3.00 ERA vs Colin Rea (Cubs) - 4-3, 4.83 ERA

The Pirates will give the nod to Paul Skenes (6-4, 3.00 ERA), who is eyeing win No. 7 on the season, and the Cubs will turn to Colin Rea (4-3, 4.83 ERA). Skenes and his team are 5-6-0 ATS this season when he starts. When Skenes starts a game and his team is the favorite on the moneyline, they have a record of 6-4. The Cubs have a 2-6-0 ATS record in Rea's eight starts that had a set spread. The Cubs have a 1-2 record in Rea's three starts this season when they were the moneyline underdog.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (55.2%)

Pirates vs Cubs Moneyline

• Chicago is a +146 underdog on the moneyline, while Pittsburgh is a -174 favorite at home.

Pirates vs Cubs Spread

• The Pirates are hosting the Cubs and are favored by 1.5 runs (+122 to cover) on the runline. Chicago is -146 to cover.

Pirates vs Cubs Over/Under

• The over/under for Pirates-Cubs on May 28 is 7.5. The over is -112, and the under is -108.

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Pirates vs Cubs Betting Trends

• The Pirates have been chosen as favorites in 32 games this year and have walked away with the win 19 times (59.4%) in those games.
• Pittsburgh has a record of 4-3 when favored by -174 or more this year.
• The Pirates and their opponents have gone over the total this season in 28 of their 55 opportunities.
• The Pirates have an against the spread record of 28-27-0 in 55 games with a line this season.
• The Cubs have gone 9-9 in games they were the underdog on the moneyline (winning 50% of those games).
• Chicago has played as a moneyline underdog of +146 or longer in only two games this season, which it split 1-1.
• The Cubs have had an over/under set by oddsmakers 55 times, and have combined with opponents to go over the total in 31 of those games (31-24-0).
• The Cubs have covered 40% of their games this season, going 22-33-0 ATS.

Pirates Player Leaders

• Brandon Lowe has 52 hits, which is best among Pittsburgh hitters this season, while batting .269 with 27 extra-base hits. He has an on-base percentage of .355 and a slugging percentage of .560.
• Among the qualified hitters in the majors, his batting average ranks 48th, his on-base percentage ranks 43rd, and he is seventh in slugging.
• Lowe has hit safely in four straight games. In his last five games he is batting .333 with a double, a home run and four RBIs.
• Bryan Reynolds has 11 doubles, two triples, four home runs and 36 walks. He's batting .266 and slugging .402 with an on-base percentage of .385.
• Among all qualified hitters, he ranks 55th in batting average, 18th in on-base percentage and 83rd in slugging percentage.
• Reynolds heads into this game looking to extend his five-game hit streak. During his last five outings he is batting .500 with three doubles, two walks and two RBIs.
• Oneil Cruz has an OPS of .777, fueled by an OBP of .324 and a team-best slugging percentage of .453 this season.
• Spencer Horwitz leads Pittsburgh with an OBP of .388 this season while batting .288 with 26 walks and 21 runs scored.
• Horwitz has hit safely in five games in a row. In his last five games he is batting .412 with two home runs, two walks and three RBIs.

Cubs Player Leaders

• Nico Hoerner has 13 doubles, four home runs and 26 walks while hitting .256. He's slugging .370 with an on-base percentage of .341.
• Including all qualified players in MLB, his batting average places him 76th, his on-base percentage is 66th, and he is 115th in slugging.
• Michael Busch has a .366 OBP to pace his team. He has a batting average of .232 while slugging .389.
• Including all qualifying hitters, he ranks 109th in batting average, 34th in on-base percentage and 97th in slugging percentage.
• Ian Happ paces the Cubs with 42 hits.
• Dansby Swanson is hitting .190 with five doubles, a triple, seven home runs and 26 walks.

Pirates vs Cubs Head to Head

• 5/27/2026: 10-4 CHC (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 5/26/2026: 12-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 8.5, Favorite Moneyline: -134, Underdog Moneyline: +114)
• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)

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