Pirates vs Cubs Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 6:12 p.m.

The Pittsburgh Pirates versus the Chicago Cubs is on the MLB schedule for Tuesday.

All the information you need to make smart wagers on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Pirates vs Cubs Game Info

• Pittsburgh Pirates (28-26) vs. Chicago Cubs (29-25)
• Date: Tuesday, May 26, 2026
• Time: 6:40 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and MARQ

Pirates vs Cubs Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PIT: (-134) | CHC: (+114)
• Spread: PIT: -1.5 (+160) | CHC: +1.5 (-194)
• Total: 8.5 -- Over: (+102) | Under: (-124)

Pirates vs Cubs Probable Starting Pitchers

Probable Pitchers: Braxton Ashcraft (Pirates) - 3-2, 2.89 ERA vs Jordan Wicks (Cubs) - 0-0, 0.00 ERA

The probable pitchers are Braxton Ashcraft (3-2) for the Pirates and Jordan Wicks for the Cubs. When Ashcraft starts, his team is 5-5-0 against the spread this season. Ashcraft's team has won 62.5% of his starts when they are favored on the moneyline (5-3). Wicks and his team were underdogs on the moneyline each time he pitched a season ago.

Pirates vs Cubs Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (55%)

Pirates vs Cubs Moneyline

• Chicago is a +114 underdog on the moneyline, while Pittsburgh is a -134 favorite at home.

Pirates vs Cubs Spread

• The Pirates are favored by 1.5 runs at home versus the Cubs. The Pirates are +160 to cover the spread, while the Cubs are -194.

Pirates vs Cubs Over/Under

• Pirates versus Cubs on May 26 has an over/under of 8.5 runs, with the odds on the over +102 and the under set at -124.

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Pirates vs Cubs Betting Trends

• The Pirates have come away with 18 wins in the 30 contests they have been listed as the favorites in this season.
• Pittsburgh has a record of 7-9 when favored by -134 or more this year.
• Contests with the Pirates have gone over the total set by bookmakers in 26 of 53 chances this season.
• The Pirates have an against the spread record of 27-26-0 in 53 games with a line this season.
• The Cubs have put together an 8-8 record in games they were the underdog on the moneyline (winning 50% of those games).
• Chicago has gone 4-1 in games it has played as a moneyline underdog with odds of +114 or longer (80%).
• The Cubs have played in 53 games with an over/under set, and have combined with their opponents to go over the total 29 times (29-24-0).
• The Cubs have a 21-32-0 record against the spread this season.

Pirates Player Leaders

• Brandon Lowe leads Pittsburgh in total hits (49) this season while batting .265 with 26 extra-base hits. He has an on-base percentage of .354 and a slugging percentage of .551.
• Among the qualifying batters in MLB, his batting average ranks 60th, his on-base percentage ranks 49th, and he is 10th in slugging.
• Lowe has picked up at least one hit in two straight games. During his last five outings he is batting .412 with a double, a home run, two walks and two RBIs.
• Bryan Reynolds is hitting .251 with eight doubles, two triples, four home runs and 36 walks, while slugging .377 with an on-base percentage of .377.
• Among all qualified, he ranks 83rd in batting average, 22nd in on-base percentage and 109th in slugging percentage.
• Reynolds has picked up at least one hit in three games in a row. In his last five games he is hitting .250 with two walks and two RBIs.
• Oneil Cruz has an OPS of .772, fueled by an OBP of .318 and a team-best slugging percentage of .454 this season.
• Cruz has recorded at least one base hit in two games in a row. In his last five games he is batting .211 with a double, a home run and an RBI.
• Spencer Horwitz leads Pittsburgh in OBP (.389) this season, fueled by 42 hits.
• Horwitz has safely hit in three straight games. During his last five outings he is hitting .333 with a home run, three walks and two RBIs.

Cubs Player Leaders

• Nico Hoerner is batting .254 with 13 doubles, four home runs and 25 walks. He's slugging .373 with an on-base percentage of .340.
• Including all qualifying hitters, he ranks 80th in batting average, while his on-base percentage is 66th and he is 114th in slugging.
• Michael Busch leads his team with a .358 on-base percentage. He has a batting average of .230 while slugging .393.
• He is currently 119th in batting average, 42nd in on-base percentage and 93rd in slugging percentage among all qualifying hitters.
• Dansby Swanson has four doubles, a triple, seven home runs and 24 walks while batting .186.
• Ian Happ has collected 39 hits to lead his team.

Pirates vs Cubs Head to Head

• 5/25/2026: 2-1 PIT (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 4/12/2026: 7-6 CHC (Favorite: Cubs, Spread: -1.5, Total: 12.5, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 4/11/2026: 4-3 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 4/10/2026: 2-0 PIT (Favorite: Cubs, Spread: -1.5, Total: 6.5, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 9/17/2025: 8-4 CHC (Favorite: Cubs, Spread: -1.5, Total: 7.5, Favorite Moneyline: -142, Underdog Moneyline: +120)
• 9/16/2025: 4-1 CHC (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 9/15/2025: 4-0 CHC (Favorite: Cubs, Spread: -1.5, Total: 8, Favorite Moneyline: -124, Underdog Moneyline: +106)
• 8/17/2025: 4-3 CHC (Favorite: Cubs, Spread: -1.5, Total: 7, Favorite Moneyline: -190, Underdog Moneyline: +160)
• 8/16/2025: 3-1 CHC (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -220, Underdog Moneyline: +184)
• 8/15/2025: 3-2 PIT (Favorite: Cubs, Spread: -1.5, Total: 8.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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