Phillies vs Pirates Prediction, Odds, Moneyline, Spread & Over/Under for May 16

Odds updated as of 4:11 p.m.

The Philadelphia Phillies are among the MLB squads in action on Saturday, versus the Pittsburgh Pirates.

We've got you covered, in terms of the vital info regarding this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Pirates Game Info

• Philadelphia Phillies (22-23) vs. Pittsburgh Pirates (24-21)
• Date: Saturday, May 16, 2026
• Time: 4:05 p.m. ET
• Venue: PNC Park -- Pittsburgh, Pennsylvania
• Coverage: SportsNet PT and NBCS-PH

Phillies vs Pirates Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-172) | PIT: (+144)
• Spread: PHI: -1.5 (-108) | PIT: +1.5 (-111)
• Total: 8.5 -- Over: (-105) | Under: (-115)

Phillies vs Pirates Probable Starting Pitchers

Probable Pitchers: Cristopher Sanchez (Phillies) - 4-2, 2.11 ERA vs Bubba Chandler (Pirates) - 1-4, 4.62 ERA

The Phillies will call on Cristopher Sanchez (4-2) against the Pirates and Bubba Chandler (1-4). When Sanchez starts, his team is 4-5-0 against the spread this season. When Sanchez starts a game and his team is the favorite on the moneyline, they have a record of 6-3. The Pirates have gone 4-4-0 against the spread when Chandler starts. The Pirates were the moneyline underdog for four Chandler starts this season -- they lost every time.

Phillies vs Pirates Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Pirates win (57.6%)

Phillies vs Pirates Moneyline

• Looking at the moneyline for Pirates-Phillies, Pittsburgh is the underdog at +144, and Philadelphia is -172 playing on the road.

Phillies vs Pirates Spread

• The Phillies are favored by 1.5 runs on the road against the Pirates. The Phillies are -108 to cover the spread, while the Pirates are -111.

Phillies vs Pirates Over/Under

• The over/under for Phillies-Pirates on May 16 is 8.5. The over is -105, and the under is -115.

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Phillies vs Pirates Betting Trends

• The Phillies have been victorious in 18, or 56.2%, of the 32 contests they have been chosen as favorites in this season.
• This season Philadelphia has come away with a win eight times in 10 chances when named as a favorite of at least -172 on the moneyline.
• The Phillies and their opponents have gone over the total this season in 23 of their 45 opportunities.
• The Phillies are 13-32-0 against the spread in their 45 games that had a posted line this season.
• The Pirates have won 37.5% of the games this season they were the underdog on the moneyline (6-10).
• Pittsburgh has played as a moneyline underdog of +144 or longer in just one game this season, which it won.
• The Pirates have played in 44 games with an over/under set, and have combined with opponents to go over the total 24 times (24-19-1).
• The Pirates have a 23-21-0 record against the spread this season.

Phillies Player Leaders

• Kyle Schwarber leads Philadelphia with 40 hits, batting .237 this season with 28 extra-base hits. He has an on-base percentage of .365 and a slugging percentage of .645.
• Among all qualifying hitters in baseball, his batting average ranks 108th, his on-base percentage ranks 40th, and he is third in slugging.
• Schwarber will look for his third straight game with a hit in this matchup. In his last five games he is batting .421 with six home runs, four walks and 10 RBIs.
• Bryce Harper leads Philadelphia with an OBP of .372 this season while batting .282 with 24 walks and 26 runs scored. He's slugging .534.
• He is 37th in batting average, 32nd in on-base percentage and 14th in slugging among qualifying hitters.
• Harper has picked up at least one hit in two games in a row. In his last five games he is hitting .286 with a home run, a walk and three RBIs.
• Brandon Marsh has hit four homers with a team-high .483 SLG this season.
• Marsh heads into this game with two games in a row with at least one hit. During his last five outings he is batting .350 with a double and an RBI.
• Trea Turner is batting .231 with a .281 OBP and 13 RBI for Philadelphia this season.
• Turner takes a two-game hitting streak into this matchup. During his last five outings he is batting .111 with a walk and an RBI.

Pirates Player Leaders

• Brandon Lowe has 38 hits, a team-best for the Pirates. He's batting .252 and slugging .563 with an on-base percentage of .352.
• Including all the qualified hitters in the majors, his batting average places him 82nd, his on-base percentage is 53rd, and he is 11th in slugging.
• Oneil Cruz is slugging .481 to pace his team. He has a batting average of .265 with an on-base percentage of .332.
• Including all qualifying hitters, his batting average puts him 59th, his on-base percentage is 90th, and he is 37th in slugging.
• Ryan O'Hearn has six doubles, seven home runs and 19 walks while batting .291.
• Bryan Reynolds leads his team with a .390 on-base percentage.

Phillies vs Pirates Head to Head

• 5/15/2026: 11-9 PHI (Favorite: Pirates, Spread: -1.5, Total: 8, Favorite Moneyline: -134, Underdog Moneyline: +116)
• 6/8/2025: 2-1 PIT (Favorite: Pirates, Spread: -1.5, Total: 6.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 6/7/2025: 2-1 PIT (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -144, Underdog Moneyline: +122)
• 5/18/2025: 1-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -108, Underdog Moneyline: -108)
• 5/17/2025: 5-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -320, Underdog Moneyline: +260)
• 7/21/2024: 6-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -122, Underdog Moneyline: +104)
• 7/20/2024: 4-1 PIT (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 7/19/2024: 8-7 PIT (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 4/14/2024: 9-2 PIT (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 4/13/2024: 4-3 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -156, Underdog Moneyline: +132)

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