Phillies vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 6:12 p.m.

The Philadelphia Phillies will face the San Diego Padres in MLB action on Monday.

All the information you need to make smart bets on this matchup at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Phillies vs Padres Game Info

• Philadelphia Phillies (26-27) vs. San Diego Padres (31-21)
• Date: Monday, May 25, 2026
• Time: 6:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-PH

Phillies vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-130) | SD: (+110)
• Spread: PHI: -1.5 (+132) | SD: +1.5 (-160)
• Total: 7.5 -- Over: (-104) | Under: (-118)

Phillies vs Padres Probable Starting Pitchers

Probable Pitchers: Jesús Luzardo (Phillies) - 3-4, 4.85 ERA vs Griffin Canning (Padres) - 0-2, 9.00 ERA

The Phillies will look to Jesus Luzardo (3-4) against the Padres and Griffin Canning (0-2). Luzardo's team is 3-7-0 against the spread this season in his starts. Luzardo's team has a record of 3-5 this season when he starts and they are the favorite on the moneyline. The Padres have gone 1-3-0 against the spread when Canning starts. The Padres were the moneyline underdog for two Canning starts this season -- they lost both.

Phillies vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (53.8%)

Phillies vs Padres Moneyline

• San Diego is a +110 underdog on the moneyline, while Philadelphia is a -130 favorite on the road.

Phillies vs Padres Spread

• The Padres are at +1.5 on the runline against the Phillies. The Padres are -160 to cover the spread, and the Phillies are +132.

Phillies vs Padres Over/Under

• The Phillies-Padres game on May 25 has been given an over/under of 7.5 runs. The over is set at -104 and the under at -118.

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Phillies vs Padres Betting Trends

• The Phillies have been chosen as favorites in 37 games this year and have walked away with the win 20 times (54.1%) in those games.
• Philadelphia has a record of 17-14 in contests when bookmakers favor them by -130 or more on the moneyline.
• The Phillies and their opponents have hit the over in 24 of their 52 games with a total set by oddsmakers this season.
• The Phillies have an against the spread mark of 15-37-0 in 52 games with a line this season.
• The Padres have a 13-10 record in games they were the underdog on the moneyline (winning 56.5% of those games).
• San Diego is 9-6 (winning 60% of its games) when playing as a moneyline underdog of +110 or longer.
• The Padres have had an over/under set by oddsmakers 52 times, and have combined with opponents to go over the total in 22 of those games (22-29-1).
• The Padres have a 30-22-0 record ATS this season.

Phillies Player Leaders

• Bryce Harper has 52 hits this season and a team-best OBP of .362. He has a .274 batting average and a slugging percentage of .526.
• Among all qualifying hitters in the majors, he ranks 45th in batting average, 37th in on-base percentage, and 17th in slugging.
• Kyle Schwarber leads Philadelphia in total hits (43) this season while batting .226 with 30 extra-base hits. He's slugging .600 with an on-base percentage of .347.
• Among all qualifying batters, he ranks 122nd in batting average, 62nd in on-base percentage and second in slugging percentage.
• Brandon Marsh has hit four homers with a team-high .463 SLG this season.
• Trea Turner has five home runs, 16 RBI and a batting average of .225 this season.

Padres Player Leaders

• Xander Bogaerts is batting .250 with three doubles, seven home runs and 19 walks. He's slugging .383 with an on-base percentage of .320.
• Including all the qualified hitters in the big leagues, he is 85th in batting average, 97th in on-base percentage and 102nd in slugging percentage.
• Gavin Sheets' 37 hits and .331 OBP both pace his team. He has a batting average of .253 while slugging .507.
• Including all qualifying players, he is 81st in batting average, 83rd in on-base percentage and 21st in slugging percentage.
• Manny Machado has five doubles, eight home runs and 25 walks while hitting .174.
• Miguel Andujar is hitting .280 with 12 doubles, two triples, five home runs and four walks.

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