Phillies vs Padres Prediction, Odds, Moneyline, Spread & Over/Under for May 25

Odds updated as of 2:12 a.m.

The MLB schedule on Monday includes the Philadelphia Phillies facing the San Diego Padres.

Here's what you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Phillies vs Padres Game Info

• Philadelphia Phillies (26-27) vs. San Diego Padres (31-21)
• Date: Monday, May 25, 2026
• Time: 6:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-PH

Phillies vs Padres Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: PHI: (-132) | SD: (+112)
• Spread: PHI: -1.5 (+130) | SD: +1.5 (-156)
• Total: 7.5 -- Over: (-105) | Under: (-115)

Phillies vs Padres Probable Starting Pitchers

Probable Pitchers: Jesús Luzardo (Phillies) - 3-4, 4.85 ERA vs Randy Vasquez (Padres) - 5-2, 2.96 ERA

The Phillies will give the nod to Jesus Luzardo (3-4, 4.85 ERA), who is eyeing win No. 4 on the season, and the Padres will turn to Randy Vasquez (5-2, 2.96 ERA). Luzardo's team is 3-7-0 against the spread in his starts this season. When Luzardo starts a game and his team is the favorite on the moneyline, they have a record of 3-5. The Padres have gone 7-3-0 against the spread when Vasquez starts. The Padres are 2-1 in Vasquez's three starts this season that they were the underdog on the moneyline.

Phillies vs Padres Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (54.9%)

Phillies vs Padres Moneyline

• The moneyline numbers for Phillies vs. Padres reveal Philadelphia as the favorite (-132) and San Diego as the underdog (+112) despite being the home team.

Phillies vs Padres Spread

• The Phillies are at the Padres and are favored by 1.5 runs (+130 to cover) on the runline. San Diego is -156 to cover.

Phillies vs Padres Over/Under

• A combined run total of 7.5 has been set for Phillies-Padres on May 25, with the over at -105 and the under at -115.

Bet on Philadelphia Phillies vs. San Diego Padres on FanDuel today!

Phillies vs Padres Betting Trends

• The Phillies have been chosen as favorites in 37 games this year and have walked away with the win 20 times (54.1%) in those games.
• Philadelphia has a record of 16-14 when favored by -132 or more this year.
• The Phillies and their opponents have hit the over in 24 of their 52 games with a total set by oddsmakers this season.
• The Phillies are 15-37-0 against the spread in their 52 games that had a posted line this season.
• The Padres have won 56.5% of the games this season they were the underdog on the moneyline (13-10).
• San Diego has a record of 9-6 when playing as a moneyline underdog with odds of +112 or longer (60%).
• The Padres have combined with opponents to go over the total 22 times this season for a 22-29-1 record against the over/under.
• The Padres have covered 57.7% of their games this season, going 30-22-0 against the spread.

Phillies Player Leaders

• Bryce Harper has 52 hits this season and a team-best OBP of .362. He has a .274 batting average and a slugging percentage of .526.
• Among all qualified hitters in the majors, he ranks 44th in batting average, 39th in on-base percentage, and 17th in slugging.
• Kyle Schwarber leads Philadelphia with 43 hits. He is batting .226 this season and has 30 extra-base hits. He's also slugging .600 with an on-base percentage of .347.
• Among all qualifying players, he is 124th in batting average, 62nd in on-base percentage and second in slugging percentage.
• Brandon Marsh has an OPS of .814, fueled by an OBP of .351 and a team-best slugging percentage of .463 this season.
• Bryson Stott has been key for Philadelphia with 39 hits, an OBP of .286 plus a slugging percentage of .405.
• Stott enters this game on a seven-game hitting streak. During his last 10 games he is hitting .324 with two doubles, two home runs, three walks and nine RBIs.

Padres Player Leaders

• Xander Bogaerts is batting .250 with three doubles, seven home runs and 19 walks. He's slugging .383 with an on-base percentage of .320.
• Including all the qualified hitters in the big leagues, his batting average puts him 83rd, his on-base percentage ranks 96th, and he is 101st in slugging.
• Gavin Sheets has collected 37 hits with a .331 OBP to pace his team in both. He has a batting average of .253 while slugging .507.
• Including all qualifying hitters, he ranks 79th in batting average, 83rd in on-base percentage and 21st in slugging percentage.
• Manny Machado is batting .174 with five doubles, eight home runs and 25 walks.
• Miguel Andujar has 12 doubles, two triples, five home runs and four walks while hitting .280.

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