Padres vs Phillies Prediction, Odds, Moneyline, Spread & Over/Under for May 26

Odds updated as of 9:12 p.m.

The Tuesday schedule in MLB includes a matchup between the San Diego Padres and the Philadelphia Phillies.

We've got you covered, in terms of the most important information about this matchup before you take a look at the MLB odds and spreads on FanDuel Sportsbook.

Padres vs Phillies Game Info

• San Diego Padres (31-22) vs. Philadelphia Phillies (27-27)
• Date: Tuesday, May 26, 2026
• Time: 9:40 p.m. ET
• Venue: Petco Park -- San Diego, California
• Coverage: Padres.TV and NBCS-PH

Padres vs Phillies Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-112) | PHI: (-104)
• Spread: SD: +1.5 (-192) | PHI: -1.5 (+158)
• Total: 7.5 -- Over: (-114) | Under: (-106)

Padres vs Phillies Probable Starting Pitchers

Probable Pitchers: Randy Vasquez (Padres) - 5-2, 2.96 ERA vs Aaron Nola (Phillies) - 2-4, 6.04 ERA

This contest's pitching matchup is set, as the Padres will send Randy Vasquez (5-2) to the mound, while Aaron Nola (2-4) will get the nod for the Phillies. Vasquez and his team are 7-3-0 ATS this season when he starts. Vasquez's team has been victorious in 80% of the games he's started as the moneyline favorite with a record of 4-1. The Phillies have a 3-7-0 ATS record in Nola's 10 starts that had a set spread. The Phillies are 2-2 in Nola's four starts this season that they were the moneyline underdog.

Padres vs Phillies Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Phillies win (50.2%)

Padres vs Phillies Moneyline

• Looking at the moneyline for Phillies-Padres, Philadelphia is the underdog at -104, and San Diego is -112 playing at home.

Padres vs Phillies Spread

• The Phillies are 1.5-run favorites against the spread for this matchup with the Padres. The Phillies are +158 to cover, while the Padres are -192 to cover as a 1.5-run underdog on the runline.

Padres vs Phillies Over/Under

• Padres versus Phillies on May 26 has an over/under of 7.5 runs, with the odds on the over -114 and the under set at -106.

Bet on San Diego Padres vs. Philadelphia Phillies on FanDuel today!

Padres vs Phillies Betting Trends

• The Padres have been chosen as favorites in 26 games this year and have walked away with the win 15 times (57.7%) in those games.
• San Diego has a record of 15-11 in contests when oddsmakers favor them by -112 or more on the moneyline.
• The Padres' games have gone over the total in 22 of their 53 opportunities.
• In 53 games with a line this season, the Padres have a mark of 30-23-0 against the spread.
• The Phillies have been the moneyline underdog 15 total times this season. They've finished 5-10 in those games.
• Philadelphia has a record of 4-8 when playing as a moneyline underdog with odds of -104 or longer (33.3%).
• The Phillies have played in 53 games with a set over/under, and have combined with opponents to go over the total 24 times (24-27-2).
• The Phillies have covered only 30.2% of their games this season, going 16-37-0 against the spread.

Padres Player Leaders

• Xander Bogaerts leads San Diego in total hits (45) this season while batting .245 with 10 extra-base hits. He has an on-base percentage of .314 and a slugging percentage of .375.
• Among all qualified hitters in MLB, his batting average ranks 93rd, his on-base percentage ranks 108th, and he is 111th in slugging.
• Gavin Sheets has 10 doubles, nine home runs and 16 walks. He's batting .253 and slugging .507 with an on-base percentage of .331.
• Sheets brings a four-game streak with at least one hit into this contest. In his last five games he is batting .235 with two walks and two RBIs.
• Miguel Andujar is batting .281 with a .484 slugging percentage and 17 RBI this year.
• Andujar brings a two-game hitting streak into this game. In his last five games he is batting .158 with a double and a walk.
• Manny Machado is batting .170 with a .265 OBP and 25 RBI for San Diego this season.

Phillies Player Leaders

• Bryce Harper a has .360 on-base percentage to lead the Phillies. He's batting .269 while slugging .518.
• Including all qualifying hitters in MLB, his batting average puts him 50th, his on-base percentage ranks 37th, and he is 18th in slugging.
• Kyle Schwarber paces his team with 45 hits. He has a batting average of .233 while slugging .617 with an on-base percentage of .354.
• Including all qualifying hitters, he ranks 114th in batting average, 49th in on-base percentage and first in slugging percentage.
• Brandon Marsh has a slugging percentage of .475, a team-high for the Phillies.
• Bryson Stott is hitting .236 with eight doubles, two triples, five home runs and 11 walks.

Padres vs Phillies Head to Head

• 5/25/2026: 3-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -118, Underdog Moneyline: +100)
• 7/13/2025: 2-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -130, Underdog Moneyline: +110)
• 7/12/2025: 5-4 SD (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -172, Underdog Moneyline: +144)
• 7/11/2025: 4-2 SD (Favorite: Phillies, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 7/2/2025: 5-1 PHI (Favorite: Phillies, Spread: -1.5, Total: 7.5, Favorite Moneyline: -156, Underdog Moneyline: +132)
• 7/2/2025: 6-4 SD (Favorite: Padres, Spread: -1.5, Total: 9, Favorite Moneyline: -116, Underdog Moneyline: -102)
• 6/30/2025: 4-0 PHI (Favorite: Phillies, Spread: -1.5, Total: 9, Favorite Moneyline: -250, Underdog Moneyline: +205)
• 6/19/2024: 5-2 SD (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 6/18/2024: 4-3 PHI (Favorite: Phillies, Spread: -1.5, Total: 8.5, Favorite Moneyline: -166, Underdog Moneyline: +140)
• 6/17/2024: 9-2 PHI (Favorite: Phillies, Spread: -1.5, Total: 9.5, Favorite Moneyline: -196, Underdog Moneyline: +164)

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