Padres vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 3

Odds updated as of 4:19 p.m.

Wednesday's slate in the MLB includes a matchup between the San Diego Padres and the Baltimore Orioles.

All the info you need to make smart bets on this game at FanDuel Sportsbook can be found below. Check out all of the latest MLB betting lines here.

Padres vs Orioles Game Info

• San Diego Padres (76-63) vs. Baltimore Orioles (63-76)
• Date: Wednesday, September 3, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-174) | BAL: (+146)
• Spread: SD: -1.5 (+116) | BAL: +1.5 (-142)
• Total: 8.5 -- Over: (-104) | Under: (-118)

Padres vs Orioles Probable Starting Pitchers

Probable Pitchers: Nestor Cortes (Padres) - 2-3, 5.06 ERA vs Cade Povich (Orioles) - 2-7, 5.04 ERA

The Padres will give the nod to Nestor Cortes (2-3, 5.06 ERA), who is eyeing win No. 3 on the season, and the Orioles will counter with Cade Povich (2-7, 5.04 ERA). Cortes' team is 3-4-0 against the spread in his starts this season. Cortes' team has a record of 2-2 this season when he starts and they are the favorite on the moneyline. The Orioles have a 4-12-0 ATS record in Povich's 16 starts that had a set spread. The Orioles have been the underdog on the moneyline in seven of Povich's starts this season, and they went 1-6 in those matchups.

Padres vs Orioles Moneyline

• Baltimore is a +146 underdog on the moneyline, while San Diego is a -174 favorite at home.

Padres vs Orioles Spread

• The Padres are hosting the Orioles and are favored by 1.5 runs (+116 to cover) on the runline. Baltimore is -142 to cover.

Padres vs Orioles Over/Under

• Padres versus Orioles, on Sept. 3, has an over/under of 8.5, with the over being -104 and the under -118.

Bet on San Diego Padres vs. Baltimore Orioles on FanDuel today!

Padres vs Orioles Betting Trends

• The Padres have been victorious in 43, or 60.6%, of the 71 contests they have been chosen as favorites in this season.
• San Diego has a record of 13-6 in contests when sportsbooks favor them by -174 or more on the moneyline.
• Contests with the Padres have gone over the total set by bookmakers in 60 of 137 chances this season.
• In 137 games with a line this season, the Padres have a mark of 75-62-0 against the spread.
• The Orioles have been the underdog on the moneyline 76 total times this season. They've gone 34-42 in those games.
• In games it has played as a moneyline underdog with odds of +146 or longer, Baltimore has gone 5-7 (41.7%).
• The Orioles have combined with opponents to hit the over on the total 59 times this season for a 59-73-4 record against the over/under.
• The Orioles have collected a 65-71-0 record ATS this season.

Padres Player Leaders

• Fernando Tatis Jr. is hitting .262 with 27 doubles, two triples, 18 home runs and 82 walks. He has an on-base percentage of .369 and a slugging percentage of .427.
• Among qualifying hitters in baseball, his batting average ranks 68th, his on-base percentage ranks 15th, and he is 79th in slugging.
• Manny Machado has 152 hits, which ranks first among San Diego batters this season. He's batting .284 with 53 extra-base hits. He's also slugging .461 with an on-base percentage of .345.
• Among all qualified, he is 22nd in batting average, 47th in on-base percentage and 52nd in slugging percentage.
• Luis Arraez leads San Diego in slugging percentage (.393) powered by 40 extra-base hits.
• Arraez enters this matchup with five games in a row with at least one hit. During his last five outings he is hitting .350 with a home run, a walk and four RBIs.
• Ramon Laureano is batting .296 with a .355 OBP and 70 RBI for San Diego this season.
• Laureano heads into this matchup on a four-game hitting streak. In his last five games he is batting .286 with a home run and four RBIs.

Orioles Player Leaders

• Gunnar Henderson has accumulated an on-base percentage of .349, a slugging percentage of .455, and has 138 hits, all club-bests for the Orioles (while batting .278).
• Including all qualifying hitters in MLB, he is 30th in batting average, 42nd in on-base percentage and 55th in slugging percentage.
• Jackson Holliday has 20 doubles, three triples, 15 home runs and 44 walks while hitting .247. He's slugging .384 with an on-base percentage of .313.
• Including all qualifying hitters, he is 104th in batting average, 112th in on-base percentage and 126th in slugging percentage.
• Ryan Mountcastle has 17 doubles, five home runs and 12 walks while hitting .266.
• Colton Cowser has 12 doubles, 12 home runs and 17 walks while batting .215.

Padres vs Orioles Head to Head

• 9/2/2025: 6-2 BAL (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -174, Underdog Moneyline: +146)
• 9/1/2025: 4-3 BAL (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -168, Underdog Moneyline: +142)
• 7/28/2024: 8-6 BAL (Favorite: Orioles, Spread: -1.5, Total: 9.5, Favorite Moneyline: -138, Underdog Moneyline: +118)
• 7/27/2024: 9-4 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -112, Underdog Moneyline: -104)
• 7/26/2024: 6-4 SD (Favorite: Orioles, Spread: -1.5, Total: 9, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/16/2023: 5-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 8/15/2023: 10-3 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -118, Underdog Moneyline: -100)
• 8/14/2023: 4-1 BAL (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -146, Underdog Moneyline: +124)

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