Padres vs Orioles Prediction, Odds, Moneyline, Spread & Over/Under for Sept. 1

Odds updated as of 6:11 a.m.

Monday's slate in the MLB includes a matchup between the San Diego Padres and the Baltimore Orioles.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Orioles Game Info

• San Diego Padres (76-61) vs. Baltimore Orioles (61-76)
• Date: Monday, September 1, 2025
• Time: 6:40 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and MASN2

Padres vs Orioles Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-158) | BAL: (+134)
• Spread: SD: -1.5 (+136) | BAL: +1.5 (-164)
• Total: 8 -- Over: (-105) | Under: (-115)

Padres vs Orioles Probable Starting Pitchers

Probable Pitchers: Dylan Cease (Padres) - 6-11, 4.82 ERA vs Kyle Bradish (Orioles) - 0-1, 3.00 ERA

The Padres will give the ball to Dylan Cease (6-11, 4.82 ERA), who is eyeing win No. 7 on the season, and the Orioles will counter with Kyle Bradish (0-1, 3.00 ERA). Cease's team is 12-15-0 against the spread this season in his starts. Cease's team has been victorious in 66.7% of the games he's started as the moneyline favorite with a record of 12-6. Bradish has started only one game with a set spread, which the Orioles failed to cover. The Orioles were the underdog on the moneyline for one Bradish start this season -- they lost.

Padres vs Orioles Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (59.8%)

Padres vs Orioles Moneyline

• Baltimore is the underdog, +134 on the moneyline, while San Diego is a -158 favorite at home.

Padres vs Orioles Spread

• The Orioles are at the Padres, and are +1.5 on the runline. The Orioles are +136 to cover the spread, and the Padres are -164.

Padres vs Orioles Over/Under

• A combined run total of 8 has been set for Padres-Orioles on Sept. 1, with the over at -105 and the under at -115.

Bet on San Diego Padres vs. Baltimore Orioles on FanDuel today!

Padres vs Orioles Betting Trends

• The Padres have won in 43, or 62.3%, of the 69 contests they have been named as odds-on favorites in this year.
• This season San Diego has been victorious 18 times in 29 chances when named as a favorite of at least -158 on the moneyline.
• The Padres and their opponents have gone over in 60 of their 135 games with a total set by sportsbooks this season.
• The Padres have posted a record of 75-60-0 against the spread this season.
• The Orioles have been the moneyline underdog 74 total times this season. They've finished 32-42 in those games.
• When it has played as a moneyline underdog with odds of +134 or longer, Baltimore has a record of 5-12 (29.4%).
• In the 134 games bookmakers have set an over/under for the Orioles, they have combined with opponents to go over the total 59 times (59-71-4).
• The Orioles have a 63-71-0 record against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. is batting .264 with 27 doubles, two triples, 18 home runs and 81 walks. He has an on-base percentage of .370 while slugging .430.
• Among all qualifying hitters in MLB, his batting average ranks 65th, his on-base percentage ranks 14th, and he is 77th in slugging.
• Manny Machado leads San Diego in slugging percentage (.466) and total hits (151) this season. He's batting .286 with an on-base percentage of .348.
• He ranks 18th in batting average, 44th in on-base percentage and 46th in slugging in the major leagues.
• Luis Arraez has collected 150 base hits, an OBP of .316 and a slugging percentage of .385 this season.
• Arraez takes a three-game hitting streak into this game. During his last five outings he is batting .167 with a walk and an RBI.
• Ramon Laureano is batting .294 with a .355 OBP and 69 RBI for San Diego this season.
• Laureano has safely hit in two games in a row. In his last five games he is batting .238 with a double, two home runs and seven RBIs.

Orioles Player Leaders

• Gunnar Henderson has accumulated 137 hits with a .349 on-base percentage and a .459 slugging percentage, all club-bests for the Orioles. He's batting .280.
• Including all qualified hitters in the majors, he is 27th in batting average, 41st in on-base percentage and 55th in slugging percentage.
• Henderson hopes to build on a three-game hitting streak in this matchup. In his last five games he is hitting .250 with two RBIs.
• Jackson Holliday is hitting .246 with 19 doubles, three triples, 15 home runs and 44 walks. He's slugging .384 with an on-base percentage of .313.
• His batting average ranks 106th among all qualified players, his on-base percentage ranks 110th, and he is 126th in slugging.
• Ryan Mountcastle is hitting .264 with 17 doubles, five home runs and 12 walks.
• Colton Cowser is hitting .211 with 12 doubles, 12 home runs and 17 walks.

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