Padres vs Marlins Prediction, Odds, Moneyline, Spread & Over/Under for May 28

Odds updated as of 3:12 p.m.

The MLB's Wednesday slate includes the San Diego Padres facing the Miami Marlins.

Here's everything you need to know before checking out today's MLB odds and spreads on FanDuel Sportsbook.

Padres vs Marlins Game Info

• San Diego Padres (31-22) vs. Miami Marlins (21-32)
• Date: Wednesday, May 28, 2025
• Time: 4:10 p.m. ET
• Venue: PETCO Park -- San Diego, California
• Coverage: SDPA and FDSFL

Padres vs Marlins Odds & Moneyline

• All MLB odds, betting lines and prop bets are available on FanDuel Sportsbook.
• Moneyline: SD: (-162) | MIA: (+136)
• Spread: SD: -1.5 (+130) | MIA: +1.5 (-156)
• Total: 8 -- Over: (-104) | Under: (-118)

Padres vs Marlins Probable Starting Pitchers

Probable Pitchers: Kyle Hart (Padres) - 0-0, 0.00 ERA vs Sandy Alcantara (Marlins) - 2-7, 8.04 ERA

This contest's pitching matchup is set, as the Padres will send Kyle Hart to the mound, while Sandy Alcantara (2-7) will take the ball for the Marlins. Hart did not pitch as the moneyline favorite last season. The Marlins have a 2-8-0 record against the spread in Alcantara's starts. The Marlins are 2-6 in Alcantara's eight starts this season that they were the moneyline underdog.

Padres vs Marlins Prediction & Pick

All MLB win probability predictions and picks are according to numberFire.
Prediction: Padres win (64.2%)

Padres vs Marlins Moneyline

• San Diego is a -162 favorite on the moneyline, while Miami is a +136 underdog on the road.

Padres vs Marlins Spread

• The Marlins are +1.5 on the run line against the Padres. The Marlins are -156 to cover, and the Padres are +130.

Padres vs Marlins Over/Under

• An over/under of 8 has been set for Padres-Marlins on May 28, with the over being -104 and the under -118.

Bet on San Diego Padres vs. Miami Marlins on FanDuel today!

Padres vs Marlins Betting Trends

• The Padres have come away with 18 wins in the 28 contests they have been listed as the favorites in this season.
• San Diego has a record of 11-4 in contests when oddsmakers favor them by -162 or more on the moneyline.
• The Padres and their opponents have gone over the total this season in 22 of their 52 opportunities.
• The Padres have an against the spread mark of 28-24-0 in 52 games with a line this season.
• The Marlins have been the moneyline underdog 47 total times this season. They've finished 17-30 in those games.
• When it has played as a moneyline underdog with odds of +136 or longer, Miami has a 9-15 record (winning just 37.5% of its games).
• The Marlins have played in 53 games with an over/under set, and have combined with opponents to go over the total 31 times (31-22-0).
• The Marlins are 29-24-0 against the spread this season.

Padres Player Leaders

• Fernando Tatis Jr. has 57 hits, which is tops among San Diego hitters this season, while batting .278 with 21 extra-base hits. He has an on-base percentage of .344 and a slugging percentage of .512.
• Among all qualified hitters in the majors, he is 40th in batting average, 56th in on-base percentage, and 24th in slugging.
• Manny Machado is slashing .316/.386/.490 this season and leads the Padres with an OPS of .876.
• Among qualified hitters, his batting average ranks him eighth, his on-base percentage 16th, and his slugging percentage 32nd.
• Machado brings a five-game streak with at least one hit into this contest. During his last five outings he is hitting .421 with a double, three home runs, three walks and four RBIs.
• Luis Arraez is batting .289 with a .416 slugging percentage and 18 RBI this year.
• Gavin Sheets has been key for San Diego with 45 hits, an OBP of .315 plus a slugging percentage of .488.

Marlins Player Leaders

• Kyle Stowers has racked up an on-base percentage of .370, a slugging percentage of .522, and has 55 hits, all club-highs for the Marlins (while batting .299).
• Including all the qualifying hitters in the big leagues, he is 14th in batting average, 32nd in on-base percentage and 17th in slugging percentage.
• Eric Wagaman is batting .246 with 10 doubles, a triple, four home runs and 14 walks. He's slugging .377 with an on-base percentage of .298.
• Including all qualified hitters, his batting average places him 101st, his on-base percentage ranks 128th, and he is 116th in slugging.
• Otto Lopez has six doubles, three home runs and 14 walks while hitting .226.
• Agustin Ramirez is batting .239 with 11 doubles, six home runs and 10 walks.

Padres vs Marlins Head to Head

• 5/27/2025: 8-6 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -162, Underdog Moneyline: +136)
• 5/26/2025: 4-3 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -152, Underdog Moneyline: +128)
• 8/11/2024: 7-6 MIA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -200, Underdog Moneyline: +168)
• 8/10/2024: 9-8 SD (Favorite: Padres, Spread: -1.5, Total: 8.5, Favorite Moneyline: -198, Underdog Moneyline: +166)
• 8/9/2024: 6-2 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -132, Underdog Moneyline: +112)
• 5/29/2024: 9-1 MIA (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -184, Underdog Moneyline: +154)
• 5/28/2024: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 7, Favorite Moneyline: -136, Underdog Moneyline: +116)
• 5/27/2024: 2-1 SD (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -196, Underdog Moneyline: +164)
• 8/23/2023: 4-0 SD (Favorite: Padres, Spread: -1.5, Total: 8, Favorite Moneyline: -126, Underdog Moneyline: +108)
• 8/22/2023: 3-0 MIA (Favorite: Padres, Spread: -1.5, Total: 7.5, Favorite Moneyline: -178, Underdog Moneyline: +150)

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